Well, I just got my latest lab results back, and things are not good.
My LDL went from 81 to 122 over the past year that I’ve been on Rapamycin and my ApoB is 102 (first time measured).
This puts me at high risk of ASCVD.
All my liver numbers are excellent. Therefore, I believe I must take a statin and put an extra load on my liver or stop taking Rapamycin IMHO.
My HBA1C is now 5.7, barely in pre-diabetes. Also not good.
My aging.Ai results are 29, in-line with where they were a year ago 28 yo and 26 yo 3 years ago). I am shocked my higher LDL and higher HBA1C did not negatively affect my age by this calculator which has made me lose faith in it.
Mice don’t die of heart attacks, but I might!
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You did it again. It is not worth discussing this further with you.
AnUser
#85
Did what? Start of your post is about 10-year risks. I’m not going to read the rest in detail if you are extrapolating from that. Go back to the drawing board and stop using 10-year risk calculators is my opinion. 
AnUser
#86
You probably have too much adipose tissue (body fat) than what your pancreas can handle, causing the HbA1c to increase. Statin might make that situation worse. If you ever wanted a reason to get on a hippie californian healthy diet, now is the time. (also calorie counting).
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Funny thing is that I’ve been dropping weight and my LDL is going in the wrong direction along with the HBA1C. Although for the latter, I have cut down my Metformin use which could be the cause.
AnUser
#88
You should try zone 2 exercise also, Inigo San Millan on Peter Attia talks about that a lot. It really nukes the blood sugar after exercising IIRC.
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Right now, I’m very concerned about the lipids. I’m sure I can get the blood sugar back in range. I’m just disappointed as I thought my supplements would have had a positive impact on my blood markers. And it appears not to be the case.
Rapamycin being a cyclical thing it strikes me that there are options other than stopping Rapamycin such as taking it less frequently and possibly associated with a fast.
I took 6mg yesterday and had a fast for the day, my previous dose was 4/6/23 (or in the USA 6/4/23). There is no real rationale for the period between doses beyond wanting to keep it at 4 weeks or higher ideally. I started by planning when to fast and took Rapamycin to fit with that.
This time I am not wearing a CGM, but I did that previously to see the effects. Which I think I saw, but it is not conclusive. That is also something I would try in your situation.
The Aging.ai methodology is quite opaque.
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zazim
#91
I am right there with you. My LDL went from 96 to 109 and my ApoB is 120 (first time tested). So I am very concerned and will be asking for 2 drugs rather than a monotherepy. But my A1c went from 5.3 to 5.2 and hsCRP went from .9 to .4 so not everything was worse. I am looking forward to my annual physical next week.
I predict he will be overly concerned about my AST jumping from 15 to 38 (I think I have figured out what happened here, so I am not concerned) and unconcerned by my lipids.
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Which two drugs will you be asking for? What amounts?
zazim
#93
He proposed a low dose statin last week. I said great and I would like ezetimibe also. He said let’s start with that. If the new LDL score changes his mind, I will ask for bempedoic acid, but will be happy with 5 mg of rosuvastatin or the lowest dose of atorvastatin.
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5-10mg rosuvastatin is what I personally take based on how well I tolerate it compared to other statins I tried. In combination with ezetimibe you can eliminate >60% of LDL.
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zazim
#95
But if those two don’t work (assuming I get both), I think I would rather pay out-of-pocket for a PSK9 inhibitor than increase the statin dose. I’m not even going to raise that possibility at this juncture.
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zazim
#96
Yes, it seems to have the most impressive results. Even in the 5-10 range. I guess I would be willing to go up to 10 MG.
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Rosuvastatin is a generic name for Crestor. It seems to be favorite among cardiologists lately. 5 MG will probably be sufficient to decrease your LDL from 85 to 70 or below.
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Loosing weight may transiently increase your LDL-C levels.
And you should not worry too much at this point. ASCVD is slowly progressing and even a year of elevated levels wont make you high risk. It takes years to develop ASCVD. Lipid levels fluctuate all the time, stress, infections etc. all raise LDL-C. Even your current lipids don’t make you high risk, but average risk.
ATM I would be more worried about high glucose. Why do you think it is Metformin that caused it? Metformin should improve insulin sensitivity and consequently lower glucose.
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No, Metformin didn’t cause it. I have been cutting my Metformin dose as I was worried about low blood sugar. I probably need to increase it again as I obviously don’t have that problem anymore.
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Oh, I see. Is the rise in glucose just rapamycin or did you have elevated glucose before too?
Is there any particular reason for why you elect to take metformin and not acarbose together with rapamycin? In the ITP trials, the combination of rapamycin and acarbose performed better than either rapamycin alone or with metformin.
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