jnorm
#385
I know some people here take melatonin, I recently started as well (2.5mg/night). There’s quite a bit of literature on it’s role in oxidative stress, but one thing that I don’t think gets mentioned enough is its effect on body temperature.
From the BLSA you can see that when study population is separated by body temperature into two halves (each with similar initial ages), the half with higher body temperature fares worse.
CR is well-known to reduce core temperature [ref], and in Rhesus it also prevents age related decline in circulating melatonin. [ref] Editing neuroendocrine system in mice to lower body temperature also produces lifespan extension. [ref]
For each group, subjects ingested either sucrose placebo or a 0.1, 0.5, 1.0, or 5.0 mg melatonin capsule at 1600 hr in a double-blind counterbalanced cross-over design… At the lower doses the mean drop in CT was between 0.05 and 0.15 degrees C and took between 2 and 3 hr. At the higher doses (1.0 and 5.0 mg), CT fell by 0.25-0.3 degrees C within 30-60 min following ingestion and at the highest dose (5 mg) remained suppressed for the duration of the study. The hypothermic effect of melatonin on core body temperature: is more better?
1 Like
Timing on Melatonin is very important. If you can it is probably best to take it after initially getting to sleep and some time during the night (also on slow release).
I have more recently, but rarely, however, on occasions taken over a gram a night. My reasoning relates to protecting mitochondrial DNA.
3 Likes
RobTuck
#387
Interesting post. Thanks @jnorm. I am not taking melatonin but my waking body temperature is ~96.2. I have speculated that this is due to genetics and low inflammation levels. I may experiment to see if melatonin lowers it further. Easy now that my watch tracks it as well. I wonder if there is a floor below which lower sleeping temps are no longer positive.
1 Like
Neo
#388
Hi Joseph, did you ever see any window come through?
I don’t recall getting a link to a recording. But I may have missed it. It’s been a while.
Arhu
#390
interesting but as a supplement hard to come by. Would annatto powder or oil work, from what I found most GG supplements seem to be made from annatto
Sorry, GG is widely available in the U.S.
Amazon has many brands and some of them claim to be from Annatto.
“Geranylgeraniol GG Supplement from Annatto”
Still another life-extending supplement?
Interesting video
Maybe using whipping cream in your coffee might be a way of getting C15
“Heavy whipping cream contains around 353 mg of C15:0 per 100g serving, making it one of the richest dietary sources.”
4 Likes
Arhu
#393
I am already liking this one, found mainly in full fat dairy and ruminant meat 
I’m interested in C15, but ~500 calories of heavy whipping cream doesn’t sound great. $40/month for a 3 month starter kit is the “fatty15” offer. I spend that on fish oil…Can I stop the fish oil and just take C15? I’ll report back here on that question if you don’t know.
José
#395
Secret??
FWIW;
Review
“Procaine–The Controversial Geroprotector Candidate: New Insights Regarding Its Molecular and Cellular Effects”
1 Like
Just kidding. 
Whipping cream also contains C16 which is not good for you
2 Likes
In the sense that the average user had no idea what it contained.
1 Like
Bicep
#398
I actually bought the idea of this over a year ago and started the fatty 15. It is expensive, but just sounded good to me.
2 Likes
Any significant subjective or blood test results?
Bicep
#400
No, thanks for the great video I had no idea it had so much going on. I’ve done a lot of reading of studies on their site.
I never felt anything at all from it, which I agree is a consideration. I tend to go by risk/benefit and things that are already being made by the body, especially something like this are pretty much risk free. So it’s just the expense, which at $300/year (I miss a few days) seems not too bad.
I wonder if there is a publicly available test I could use to check my levels.
1 Like
@Bicep what do you buy for $300/year? I saw $40/month as my potential cost.
1 Like
SNK
#402
You may be right when you say overweight older people may look/seem younger (look wise) but in some cases (Trump included) the image of being strong/healthy has more to do with how they carry themselves (i.e. gait, walk tempo, energy, etc…) that gives people impression a person being strong or healthy. I agree however that looks can be deceiving because I know few older persons (3) who looked good the day before to not wake up the next morning because of a heart attack.
Bicep
#403
Yeah, you are correct. I have a subscription and don’t really pay close attention… had to make my wife look it up on the credit card. Actually I started out paying $120 every 90 days, but now it looks like I pay $130 every 90 days.
And I agree that probably a person should double this dose, so it’s even more than that to do it right.
1 Like
jnorm
#404
My regimen lately has been:
6mg rapamycin 1x/week
caffeine 200mg
500mg tributyrin
1mg finasteride
3g glycine powder upon waking, some nights a second 3g dose
1g taurine 3x/day
500mg AAKG 3x/day (need to be more consistent)
1g piracetam most days
2.5mg melatonin before bed
5mg lithium orotate every 2-3 days
20g collagen peptides 1x/day
Also consume quite a bit of wild blueberries and matcha lately, so some interesting molecules coming from there as well
Skin health:
Skinceuticals products: CE Ferulic and Hydrating B5 gel and spf50 mineral sunscreen. I use the sunscreen mainly on my face and neck. Try to get sun without burning on my upper body for potential cardiovascular benefits. The CE Ferulic on face, neck and upper body, and the hydrating B5 gel on face and neck.
I’ve been using the CE Ferulic for a couple years now, but in the past month I also started the B5 gel. I think my skin has been looking the best it’s ever looked, so I will stick with these products even if they are considered overpriced.
Mental Health: Trying to do at least 2x 10-20 minute guided meditations per day to reduce irritability and gain better control of my thoughts, emotions, and behaviors. Also going to join a local softball and basketball league to try and make some friends outside of my academic life.
Was using tyrosine pretty consistently but recently stopped because the effects faded. Also tried to start acarbose again but it fucks up my appetite and also seems to make me moodier, so I dropped it again.
Oh yeah, and have added famotidine 10mg 3-4x/day the past couple weeks and it’s remarkably been managing my GERD and chronic gastritis symptoms. It’s allowed me to cut way back on Gavison and being able to eat more types of food. I’ve also started having loose stools consistently basically every day the past couple weeks which is a possible side effect of famotidine. I don’t think it’s the rapamycin since I’ve been taking it for 5 months now and that wasn’t a consistent issue before.
I’ve got 17alpha-E2 and I want to start that soon, just haven’t been able to find the time and motivation yet. If topical will probably just follow Bryan Johnson’s protocol.
6 Likes
