That is a lot of PEA… 600mg is double the usual. Is that a daily dose for you?
I look to studies to understand dosing of specific compounds. One has to read quite a few as there will be contradictory information over time. That’s the nature of science, it requires near constant reading 
When Linus Pauling was hyping high dose Vit-C, I followed along. Was taking 4gm a day for quite a few years. As I continued to read more current studies that contradict the anti-oxidant theory of aging I’ve cut back my Vit-C to 1gm per day.
Similar issues with Vit D, I now take 1,000 IU’s which is much less than what I took 15 years ago.
So it’s an ever changing landscape regarding dose.
Consider Rapamycin and the contradictions with this important compound.
One thing I never do is “follow” influencers, there are levels of influencers while some are worth following, the majority are not… Especially if they are Doctors or Phd somethings on social media. I will listen a bit to their pitch but then I go read the studies on the topic / compound / intervention they are promoting to see if there is any solid basis for their pitch. This can take weeks of reading and asking questions of people who can help explain the nuances.
Here on this forum I do listen to the Doctors and Phd’s as I find they aren’t promoting the newest latest fad but are genuine in trying to educate those of us who are not nearly as well educated in the science.
I’m fortunate to have 3 very excellent science advisors that I can bounce questions off. One Dr, 1 Phd biochemist and 1 Professor who specializes in teaching Ayurvedic concepts at a local university and runs a significant research program in cancer research.
Here is an article on Linus Pauling and Vit-C.
In 1970, Pauling came out with his book Vitamin C and the Common Cold, where he encouraged Americans to consume 3,000 mg of vitamin C daily.
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SNK
#488
He specifically “hyped” in conjunction with L-Lysine I think. And. to that end I am proof that high doses of both Vit C and Lysine do keep cold viruses away. As far as science though they opt for lowest daily values, but in my anecdotal experience I have zero positive effects at those doses. As an example while many take a multivitamin, I have Never gotten any positive effect of taking a multi, which I stopped long time ago. I do however get noticeable effects (positive)if I take 30000 IU of Vit D as an example, or when I take 4-8Gr of Vit C and Lysine against colds. I have tried 1000MG of Vitc and same with Lysine but It did nothing for the cold virus unless I upped the dose to over 4000 of each per day, To be clear I only do such high amounts in flu season or at onset of symptoms, but for me it works 100% of time. I also get specific noticeable positive results when I take high amounts of some aminos, or even B vitamins. I feel no such effects if I lower the doses.
As for RAPA I honestly am not sold on it and have decided to do a very prolonged pause. In my case it appears to promote infections in the skin and in airways and don’t want to take something else to counter that.
Long story short the recommended daily values to me are useless for therapeutical purposes, while they may be ok for Maintenace if you happen to be a very active person and in excellent health (less than 1% of populace).
And. lastly the only think that I tend to agree with (with regards to longevity) is the calorie restriction and/or fasting. The results are so obvious that it is real hard to argue against. Anything else seems uncivilized😂, since I do get noticeable negative effects from metformin, acarbose, and RAPA as an example. Nothing Zero negatives when I do fasting or CR.
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Others swear that ivermectin protected them from covid…
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Neo
#491
Seems like a crucial/the crucial part should be measurement - especially for things like Vit D where the tests are quite good and readily available
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SNK
#492
Hi most PEA supplements here in Australia including compounded are 300mg twice a day. I chose this one for neuralgia (occipital and genicular post covid) because my functional doctor- a biochemist suggested it as more a therapeutic dose. It worked over about ten days and I can now sleep. I was taking sleeping pills, melatonin, full spectrum CBD -the latter somewhat helpful. Now I use the PEA when I have pain and I only use Ecklonia Cava for sleep. For the first time in years I am pain free and off all sleeping pills. For me that dose was effective when I needed it. At the moment though I dont need it. Just taking ecklonia cava for sleep (who knew) and its been surprisingly effective.
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What dose of ecklonia cava are you taking for sleeping? Thx
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Thank you, @desertshores — strong personal experience descriptions with loads of detail are very helpful (for me, at least).
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Hi I am using the Swanson Brand- not easy to get Ecklonia here in Australia and since I had not used before went with the cheapest brand. I have had very bad insomnia for years and to tell the truth did not expect much but I am a fan of fucoidan for general health and was interested that many on iHerb said it helped with sleep- took a chance. Been on just over a week and am off sleeping pills (Zolpidem) and melatonin. I have just got CBN/CBD after a lot of hassle here but have not tried it as yet. I feel if I can sleep it helps so much with everything. The Ecklonia is gentle- its not a sedative works more like diazepam. I still wake up in night but no anxiety and I sleep soundly.
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" it is more dose-dependent than the literature suggests because I felt no significant benefits until I increased my dose to 10 grams daily."
I agree, Taurine could be more dose-dependent than I had thought. A few weeks ago, I started taking 10 gr on empty stomach each morning.
A few years ago, I started to take Taurine when I woke up during the night (and sometimes before sleep). Then I got the best effect from approx. 1–2.5 grams; it did not make me go back to sleep immediately, but calmed my mind and therefore improved my sleep.
Now that I am ingesting 10 grams in the morning, I feel energetic, happy, and stress-resilient the whole day. Previously, when I tried 4-5–6-7 grams, Taurine did not have these effects on me. I speculate that Taurine has to reach a certain threshold to have these effects on me, and that different doses might have different effects. I do hope that these effects last. It is a game-changer for me. In two to three weeks I will have my biomarkers checked.
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Because Taurine is a metabolite it is quite likely to be something that needs quite a bit to move the needle. I may try increasing mine. I am taking a trivial 1g at the moment.
On the other hand I am doing quite well with everything anyway. However, we should not be surprised if you need to take a large amount of taurine to have a noticeable effect.
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I have to add that for me, caffeine does not work well with Taurine (unless it is for improving exercise performance). I can only take a tiny bit of caffeine after 10 gr of Taurine. If I drink too much, I get a caffeine crash and brain fog.
When this is said, I also have to add that, according to DNA analysis, my caffeine metabolism is prone to being quite inefficient.
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Caffeine is supposed to block absorption of taurine just like Glycine as it binds to the same receptor. Maybe you’re getting a taurine crash? I.e. you can’t absorb the taurine due to the caffeine.
LukeMV
#502
Really? That’s ironic given the fact that caffeine and taurine are frequently combined in pre workout and energy drinks
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So this morning i just started my second attempt to take creatinine (monohydrate) regularly, by mixing 5g into my morning coffee (with glycine). I stopped taking it the first time because it tasted so bitter to me and was unpleasant, and i never found a good routine to take it in the middle of the day before the gym, and i am hoping just putting it in my morning coffee will solve that. I hope it wont compete with my glycine (which I take with collagen and NACET in the morning).
HOWEVER the taste is still very bitter so i looked it up:
What Does Creatine Taste Like & Pro Tips To Improve Its Taste.
“ For instance, by-products from the synthetic production of creatine, such as dicyandiamide, can impart a slightly bitter taste to creatine monohydrate.”
dicyandiamide??? Sounds ominous. And I checked out its chemical structure and it has the classic cyanide triple bonded nitrogen.
From the dicyandiamide material safety sheet:
“ Caution! May be harmful if swallowed. Harmful. Methemoglobin forming agent. May cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). May cause irritation.
Target Organs: Blood.”
So I’m probably overthinking this, but i always worry about unintended consequences of blindly taking supplements or drugs (more worried about drugs) which would actually diminish/harm healthspan/lifespan. If i can taste it (the bitterness), it is in high enough concentration to have a physiological effect, yes?
For those of you with some background in this, what are your thoughts? Ignore it and keep on with creatine? Maybe a bad batch and try another? Or ditch it?
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Neo
#505
Have you tried different brands?
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I had never heard of this before so I tried a ¼ tsp under my tongue and it tasted neutral to me.
Perhaps your taste buds are more sensitive than mine because you are younger.
I have been using “BulkSupplements.com Creatine Monohydrate Powder - Creatine Supplement, Micronized Creatine, Creatine Powder” for many years and it is essentially tasteless to me. The "micronized versions mix easily with most anything. I usually put it in my coffee but occasionally mix it into a protein drink. 5 grams of creatine in anything like coffee doesn’t change the taste as far as I can tell.
I’m not too fond of the taste of glycine in anything, so I take the capsule form.
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When I buy creatine monohydrate, then I go for products using Creapure creatine.
When I buy other brands, then I don’t know were it is made or how it is made.
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