No - its not available (per CGPT5).
So, I looked a little more deeply into the issue of lipids (LDL-C and APO-B) and centenarians and supercentenarians…
Interesting to note, it seems there are no groups or studies suggesting higher lipid levels are well represented in centenarians and supercentenarian.
AI Summay:
Here’s what the peer-reviewed literature says about LDL-C levels in centenarians / super-centenarians, with numeric data where it’s actually reported.
What the data show (study-by-study)
Italy – healthy centenarians (n=75), classic FASEB J cohort (1998)
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LDL-C: 115.1 ± 27.8 mg/dL (calculated by Friedewald).
- Compared with younger and “elderly” controls, centenarians had LDL similar to young, lower than elderly; HDL was lower and TG higher in centenarians.
China – Hainan community centenarians (population cohort)
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LDL-C (median): 2.77 mmol/L ≈ 107 mg/dL; TC 4.60 mmol/L, TG 1.05 mmol/L, HDL-C 1.41 mmol/L.
- Dyslipidemia prevalence ~19%. (This is the Hainan centenarian cohort referenced in later work.) (Frontiers)
China – inpatient centenarians (n=121), single-center retrospective (2022)
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LDL-C (mean): 2.05 ± 0.46 mmol/L ≈ 79 ± 18 mg/dL; TC 3.90, TG 1.36, HDL-C 1.14 (all mmol/L).
- 69% were on lipid-lowering therapy (mostly statins).
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Lower LDL-C associated with higher all-cause mortality in multivariable models (HR for LDL-C 0.379; p=0.001) — authors caution about “lowest is not best” in this hospitalized, heavily treated group. (Frontiers)
Okinawa, Japan – long-lived population (reviewed)
- Older report (2001): LDL-C ≈ 102.4 ± 25.1 mg/dL; later cohort: 113.0 ± 27.8 mg/dL; more recent generations show upward drift. (Values summarized in a 2025 review). (MDPI)
Italy – “lipid & lipoprotein subfractions in centenarians,” Very Large Database of Lipids (JACC abstract, 2016)
- Centenarians had a less atherogenic lipid profile (emphasis on particle subfractions—larger LDL/HDL particles) rather than LDL-C concentration per se. (JACC)
Mongolia – centenarians vs elderly controls (2024)
- Reported hypercholesterolemia 32.6% in centenarians, but elevated LDL only 4.3%; numerics for mean LDL-C not provided in abstract. (Cajmhe)
Other relevant signals
- Some centenarian cohorts (e.g., Ashkenazi families) emphasize lipoprotein particle size (larger LDL/HDL) over LDL-C level itself. (Science)
- In female centenarians, estradiol levels inversely correlated with LDL-C in one Hainan sub-study. (DNB Portal)
Supercentenarian (110+) data: direct LDL-C values are rarely published. For María Branyas Morera (117), the Cell Reports Medicine paper emphasizes lipid particle features and metabolomic signatures, not a numeric LDL-C value. (Cell)
Quick comparison table (LDL-C)
Population |
Setting / N |
LDL-C (mg/dL) |
Notes |
Italy (Padova) |
Healthy centenarians, n=75 |
115.1 ± 27.8 |
LDL similar to young; lower than elderly. |
China (Hainan) |
Community centenarians |
~107 (median) |
2.77 mmol/L; low dyslipidemia prevalence. (Frontiers) |
China (PLA hospital) |
Inpatient centenarians, n=121 |
~79 ± 18 |
Heavy statin use (69%); low LDL linked to ↑ all-cause mortality. (Frontiers) |
Okinawa (historic cohorts) |
Population studies (reviewed) |
~102 → 113 |
Cohort/time dependent; upward drift over generations. (MDPI) |
Various (JACC VLDB) |
Subfraction profiling |
— |
Centenarians showed less atherogenic particles (size pattern), not LDL-C per se. (JACC) |
(mmol/L → mg/dL for cholesterol: × 38.67)
How to read this
- Across community-dwelling centenarians, LDL-C clusters around ~100–115 mg/dL in several cohorts.
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Hospitalized/treated centenarians can show much lower LDL-C (often due to statins), and in at least one study, lower LDL-C correlated with higher all-cause mortality, likely reflecting illness, frailty, and treatment selection rather than a protective effect of very low LDL in this age stratum. (Frontiers)
- Many “longevity” papers in the last 10–15 years shifted attention from LDL-C concentration to lipoprotein quality (particle size/composition), which appears more favorable in long-lived families and centenarians—even when LDL-C isn’t exceptionally low. (JACC)
Bottom line
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Numeric LDL-C in centenarians: typically ~100–115 mg/dL in community cohorts; lower (~80 mg/dL) in hospitalized, heavily treated samples.
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Supercentenarians: no robust, published LDL-C datasets; case studies focus on efficient lipid metabolism & particle profiles rather than LDL-C numbers. (Cell)
APO-B Summary:
Here’s what the published literature actually reports on Apolipoprotein-B (ApoB) in centenarians / super-centenarians. Spoiler: there are only a handful of cohorts with measured ApoB; most “longevity lipid” papers focus on particle size (LDL/HDL) rather than ApoB counts.
Studies that report ApoB in (or around) centenarians
Study / cohort |
Who was measured |
ApoB (units as reported → mg/dL) |
Key takeaways |
Malaguarnera et al., 1996 (Clinical Drug Investigation) |
Italian centenarians vs. controls |
0.92 ± 0.26 g/L → 92 ± 26 mg/dL |
Centenarians had lower TC, LDL-C, TG and ApoB, and higher HDL-C/ApoA-I vs. controls. (SpringerLink) |
Barzilai et al., 2003 (Ashkenazi “exceptional longevity”, JAMA) |
Long-lived probands (centenarians), their offspring, age-matched controls |
ApoB (all probands): 96 ± 22 mg/dL; men: 91 ± 19 mg/dL (controls ~100–104 mg/dL depending on subgroup) |
Longevity phenotype emphasized larger LDL/HDL particle sizes; ApoB similar or modestly lower than controls. Table shows ApoB alongside LDL/HDL and particle metrics. (JAMA Network) |
Hazzard, 2001 (J Am Geriatr Soc commentary/series) |
9 very old “long-livers” |
ApoB ~61 mg/dL (LDL-C ~65 mg/dL) |
Small, selective sample with very low ApoB and LDL-C; not population-representative, but shows the lower tail exists. (AGs Journals) |
Atzmon et al., 2006 (PLoS Biology) |
Ashkenazi centenarians & offspring (genetic study) |
ApoB measured (with ApoA1/ApoC3), but paper centers on APOC3/CETP variants and particle size; no single cohort-wide ApoB mean is highlighted |
Confirms favorable lipoprotein profile in long-lived families; emphasis is genetics & particle size, not ApoB concentration per se. (PLOS) |
Heijmans et al., 2006 (PLoS Medicine) |
Long-lived siblings (men ≥ 89, women ≥ 91) & population peers |
Focus on LDL/HDL particle size & concentrations; ApoB not the headline metric
|
Shows larger LDL & HDL particles track with longevity in families and in sporadic 90-year-olds. (PLOS) |
Italian Multicentric Study on Centenarians, 1998 (Arch Gerontol Geriatr) |
Large Italian centenarian sample |
Paper tables include TC/HDL/TG & ApoA-I (ApoB data discussed in references to standardization but not tabulated in this report) |
Confirms broadly benign lipid panels in healthy centenarians; this particular report doesn’t list ApoB means. (Air Unimi) |
Super-centenarians (110+): I could not find any peer-reviewed study reporting ApoB concentrations specifically in super-centenarians. The recent multi-omics case on the 117-year-old (M116) reported lipid particle features/metabolomics but not ApoB. (Your uploaded paper also omits ApoB.)
What these data suggest (with important caveats)
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Typical ApoB levels in community centenarians sit around ~90–100 mg/dL in the two most informative cohorts (Italian and Ashkenazi). That’s not “ultra-low” by modern preventive cardiology standards, but not high either. (SpringerLink)
- There is heterogeneity: selected case series can show very low ApoB (~60 mg/dL), but those are tiny, non-representative samples. (AGs Journals)
- Many longevity cohorts shift the focus from ApoB amount to lipoprotein quality (especially larger LDL & HDL particles), which repeatedly associates with long life even when absolute LDL-C/ApoB aren’t dramatically different. (PLOS)
- Some papers in the “oldest-old” (80–99) literature examine ApoB for risk prediction, but they’re not centenarian-only; results often show the usual pattern (higher ApoB → higher ASCVD risk), with possible attenuation in very old age and strong treatment/selection effects. These are helpful context but not direct centenarian ApoB catalogs. (Nature)
Bottom line
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Direct ApoB measurements in bona fide centenarian cohorts are scarce. Where measured, ApoB ~90–100 mg/dL is common (Italian, Ashkenazi cohorts). Exceptional low values exist in small, selected samples. The strongest and most replicated lipid signature of longevity is large LDL/HDL particle size rather than very low ApoB per se. (SpringerLink)