1.5x Higher Urate (Uric Acid) Increases Mortality by 49% and Cancer by 22%

[AnUser]

In 45 year olds:

RESULTS

During a median follow-up time of 3.9 years for cancer and 4.9 years for all-cause mortality, 3243 individuals received a diagnosis of cancer and 3978 died. Observationally, 50% higher plasma urate was associated with multivariable-adjusted hazard ratios of 1.11 (95% CI, 1.05–1.18) for cancer incidence and 1.07 (1.01–1.13) for all-cause mortality. Each A-allele of the SLC2A9 rs7442295 was associated with 9% higher plasma urate and hazard ratios of 1.07 (1.01–1.14) for cancer incidence and 1.07 (1.02–1.13) for all-cause mortality. In instrumental variable analyses, the odds ratios for a genetically determined 50% higher plasma urate was 1.22 (1.02–1.47) for cancer incidence and 1.49 (1.13–1.93) for all-cause mortality.

CONCLUSIONS

High plasma urate was both observationally and genetically associated with high cancer incidence and high all-cause mortality, suggesting causal relationships.

https://academic.oup.com/clinchem/article-abstract/63/6/1151/5612928