Update from Ora: “Looks like your experiment (ORC1034) got started 6/13. With post-experiment data analysis and QC, I would estimate data will come back to you around the week of July 21st.”
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Apologies for the delay. Yes, I’m taking rapamycin, and have been for about 6 months. I’m not sure what mechanism would make IPAM an immune system inhibitor, or how it would enhance the mTOR inhibiting effects of Rapamycin.
That being said, I feel like my immune system got slaughtered after that single dose of IPAM. There were the ulcers; and I also got a really bad cold that I still haven’t recovered from. I haven’t been sick like this for the past few months, even though my family has been sick several times (maybe thanks to rapa?). This time it was the opposite, I came down hard but the rest of the fam is okay.
I’ll be curious to see other’s reactions for those willing to give this a shot. Maybe what I experienced is a one off reaction and others will have a smoother rider; and maybe this is all a coincidence on my end and not IPAM related at all (doubtful, but maybe).
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This is the first time I realize there’s a difference 
; I believe these were canker sores because they were inside my mouth, less around my lips.
What implication does this have (if any)?
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medaura
#187
It’s a typical reaction to rapamycin believed to be caused by the slow down in the epithelial mucosal cells’ turnover rate inside your mouth. The implication is that it sucks. But at least it doesn’t mean that rapamycin is causing a herpes simplex 1 outbreak for you. Once I had a cold sore right around my rapa dose and it got me wondering if it was causal but it wasn’t repeated so I assume it was just a fluke.
Interesting. I’ve gathered user reports from a variety of places and not once have I heard of such a reaction.
The thing with IPAM is anyone who is willing to consume it is willing to consume a wide array of molecules so it’s difficult to pinpoint it.
It’s possible that IPAM, much like rapamycin, is processed by the CYP3A4 enzyme. Certain supplements and medications lead to the inhibition of this enzyme which causes any drug that is metabolized by it to stay active in the body for longer than it normally would. This is why people intentionally take grapefruit juice with their rapamycin.
Any updates from anyone taking IPAM?
I ordered 1g for myself and I have been taking it occasionally. Hard to say what it is doing as I use a variety of supplements, medications and devices for longevity and wellness. It might have a sort of nootropic effect? No negative effects that I have noticed.
I’ve been researching how the human body endogenously produces IPAM and have been implementing this. I feel good on this protocol, which is mostly focused on nitric oxide and gut microbiotia optimization. As I learn more and truly figure this out I will post the protocol.
The lifespan study is underway currently, the moment I am notified of any updates I will make a post.
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Well took my first 2mg which just arrived from Everychem. It was about 5 minutes ago and not dead yet. This is good news given the obvious irony.
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I’m still alive as well lol.
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I tried again yesterday with a very small dose, 0.3mg (measured on a very expensive scale). No noticeable effect. I’m planning to titrate up over the next few weeks.
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There will be an update soon with the lifespan test. Sorry about the wait!
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Thank you for organising this. It is useful to have what in a limited way are negative results. It does mean in terms of indoles that IPAM would not be currently at the top of my list for personal experimentation even though I am not a massive fan of worm experiments. However, this is good basic science giving us further information about the molecule. I think you are right to try higher doses.
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No problem John. I’m still hopeful. The significantly higher doses should give us an indication if this is worth pursuing further.
A big shoutout to Ora for facilitating the next study so quickly.
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That’s true, but sadly the worm is not that good for modelling mammalian lifespan.
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adssx
#198
Too bad it failed! I would be surprised if higher doses work. I’m also disappointed that Ora still hasn’t sent me results from experiments sponsored as far as April 2024…
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Email them and find out what is going on.
adssx
#200
I did so. I also had a call with Ben last month. Wait and see…
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Thanks very much for organising this - very interesting! First time I’ve been involved in helping sponsor longevity related research…. 
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This is my first time doing something like this as well. It’s very exciting to feel like we’re contributing something instead of just being passive observers hoping something will happen.
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