Vlasko
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“The human brain shrinks as it ages, affecting the ability to remember — it’s part of life. Yet there are a lucky few, called SuperAgers, who possess a brain that fights back. For these people, memories stay as sharp as they were 30 or more years in the past.”
Life extensionst Paul Kiesow (73), believes low-dose Deprenyl (selegiline) at 1.25 mg daily has prevented most of this age-related shrinkage. Paul has a 15 minute video presentation on X on this topic.
“Another common thread in all SuperAgers is a sense of autonomy, freedom and independence. They’re making decisions and living their lives the way that they want to live.”
One take I have on this is to adjust your lifestyle, including your social contacts, to minimize stress.
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Yes, but then again, you have the “ornery old geezer” type who gets into fights with everyone, but lives forever 
… I’ve seen this more than once - it’s as if the orneriness keeps ‘em going, lol. But also, people who don’t just go along with the crowd for the sake of getting along, are willing to stand up for themselves, own their opinions and don’t take any guff might indicate high independence and functioning.
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I am an 81 year-old woman, and I have a great memory, I play good golf, I am learning to play the keyboard and can already play several songs, I only started two months ago. I take a supplement called memory formula, by Dr. Shallenberger., I have been taking that for the last six years, I was finding it difficult to remember golfers names, however after just a month, I noticed that I could remember the names of my golfing partners. I used to take at least 20 supplements in pill form, but I have changed most of them now to Gomez, which makes life much easier. I have macular degeneration so I do not have any central vision however, I don’t let this stop me. I cook clean play golf read and do lots of research on longevity. I am thinking of trying Modifini as an experiment to see if I can focus more on learning to play the keyboard., has anyone tried that and if so, what are your thoughts?
Finding the correct dosage is crucial when taking modafinil. Because it has a half-life of ~15 hours, it will build up in your system and not return to baseline if you take it every day.
“The most commonly prescribed dosage for modafinil is 200 mg per day. This dosage is typically recommended for adults to improve wakefulness associated with conditions such as narcolepsy, obstructive sleep apnea, and shift work disorder.”
“Elderly people typically need a lower dose of modafinil. The search results indicated that for older patients, a lower initial dose should be considered with close monitoring, as their ability to eliminate the drug and its metabolites might be reduced.”
So, I started with 100 mg. I thought it was great, no afternoon drowsiness, more mental alertness, and focus. I don’t know if it has any effect on memory.
The first night, I had a harder time going to sleep at my regular time. The next day, I took another 100 mg dose and did not get a good night’s sleep.
To make a long story short, I titrated down to 25 mg. This reduces afternoon sleepiness and doesn’t affect my sleep.
I do not take it every day. I take it on days that I wake up with a bit of brain fog.
Modafinil is one of those drugs that, from anecdotal reports on Reddit, etc., has a wide range of effects on different people. I think it definetly is worth a try. Just be prepared to lose a little sleep if you take too much.
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Thank you for your information. , I sleep well but get up around 4 am so by 2/3 pm I am tired , I will start with 25 mg, hope I can cut the tablets. I read on this site about Modafini giving great focus. I’m just trying it out to see how I feel and I won’t take it every day now I have read your response
Thank youn
