#1

Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209668/

It reduces oxidized LDL and fructosamine

But I feel standard dosages are too low

This process causes loss of allicin and increases activity of other water-soluble organosulphur compounds, such as S-allyl cysteine (SAC), S-allyl mercaptocysteine (SAMC), allixin and selenium, all of which are antioxidants8,10. Another antioxidant present in aged garlic extract is N-fructosyl arginine, which is not present in raw or heat-treated garlic preparations

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#2

Still, oxidized cholesterol is what’s bad and he didn’t mention it. LDL id not inherently bad and

#3

I aim to take Allicin in Allicin Max as an HS donor. Not sure it has any effect on me, however.

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#4

Blueprint / Bryan Johnson’s protocol is

First and last meal, so 2 x per day:

Think the first one is “fresh” and the second one is aged.

What are people’s and @L_H @scta123 @AnUser @Bicep @medaura s thoughts on its ability to stop and reverted plaque in arteries and arterial hardening?

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#5

I think its role as an HS donor is making building new mitochondria easier.

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#6

It probably reduces LDL cholesterol a little bit, but not much.

What do you mean with inherently?

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#7

Not valuing the Apo B a/ LDL lowering that much here as we can take care of that in more powerful ways (and I am) - more integrated in the benefits around offsetting and reversing plaque, artery hardening and positive effects on inflammation and oxidation.

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#8

How do you know that’s happening though for sure relative to LDL reduction?

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#9

Would the ITP even detect a longevity benefit in mice with any cardiovascular medication/supplement? They mice strains used don’t typically develop plaque. 90% of them die from cancer.

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#10

There are very good indications that lowering LDL-C below a certain treshold reduces plaque volume.

Intensive lipid lowering agents and coronary atherosclerosis: Insights from intravascular imaging - PMC (nih.gov)

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#11

I wanted to learn about it, that is why I asked that very question:

What are people’s and @L_H @scta123 @AnUser @Bicep @medaura s thoughts on its ability to stop and reverted plaque in arteries and arterial hardening?

That is how I opened this sub-discussion…

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#12

Hi @Virilius - Not sure why you are asking me that - I 100% agree that this is a huge issue with any studies that use rodents to model human longevity, and I have said so in the past.

At the same time, I think if there is support that in humans it lowers plaque / even reverses it then it’s exciting to look into more;

Yes, aged garlic extract (AGE) can reduce low attenuation plaque (LAP), also known as “soft plaque”, in coronary arteries. LAP is more likely to break off and cause a blockage that leads to a heart attack.

In a 2016 study published in the Journal of Nutrition, 55 patients with metabolic syndrome who took 2,400 milligrams of AGE every day for a year experienced an 80% reduction in total plaque accumulation and a reduction in soft plaque. Another study found that one year of AGE therapy was associated with a regression of LAP in patients with diabetes.

AGE is made by soaking garlic slices in alcohol for up to 20 months, which produces more potent antioxidants than fresh garlic extract. Garlic also contains sulfur-containing compounds that may help fight heart disease and prevent some cancers.

  • This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.
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#13

I guess we’ll have to wait for someone to post a mechanistic speculation study in MDPI.
Especially if you ask about buzzwords like offsetting plaque, reversing plaque, reversing artery hardening, improving inflammation, improving oxidation.

It requires follow up questions like (1) what do you mean with stop plaque in arteries and how do you measure it, (2) what do you mean with revert plaque, what are the established thresholds… etc… What are the goal posts…?

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#14

The studies are small but promising.
This is quite a good overview on garlic and aged garlic.

I can confirm it’s delicious.

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#15

My framework is that the evidence burden can be lower for things that less likely to have risks (filter one’s water, avoid plastics, avoid processed food, eat some berries and a variety of veggies, work on good sleep routines, excesses across strength and cardio, etc) vs other things (like my decision to take Rephatha, to do water only fasts, and to consider rapa and cana).

In between, but closer to first type of decision are things like supplementing Omega 3 and Vit D (from good, well researched sources).

I think taking garlic (in non-crazy dosages) is around that low-ish risk bucket. Hence the certainty around benefit can be smaller for it still do be a bet to take today. Of course future data may then update that decision.

But yes, I wanted to see if some people in our hive mind might already have looked into this and have any more insight beyond that it seems that Blueprints process led them to decide it’s a worthwhile risks/reward.

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#16

I read this a few years ago:

So I take 2 of these per day:

Then I take aged garlic also, though I don’t know why:

https://www.amazon.com/Micro-Ingredients-Organically-Antioxidant-Supplement/dp/B0812DJRSK/

I agree that I take it because I believe the benefit is likely and the risk is essentially zero.

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#17

They still have costs.

#18

Yes, but not crazy ones here.

#19

I smell some of it after taking it which is actually really good reiforcement

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