Aging lysosome might be of interest in aging diseases

Guywholikessleep · 2023-10-20T12:13:08.605Z

Not sure if anyone has talked about this but some interesting work has come out in regards to lysosome’s and neurodegenerative diseases.

PubMed Central (PMC)

The aging lysosome: an essential catalyst for late-onset neurodegenerative...

Lysosomes figure prominently in theories of aging as the proteolytic system most responsible for eliminating growing burdens of damaged proteins and organelles in aging neurons and other long lived cells. Newer evidence shows that diverse...

PubMed Central (PMC)

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces...

Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy ...