Anti-aging Benefits of Rapamycin, Personal Experiences (part 2)

[JazzMann]

Same here. I now have virtually no allergies. I’m not sure when this happened because I live in Australia and my allergies are particularly bad in the UK. Grass pollens and Horse Chestnut trees are the worst - go figure. I started Rapa in November 2021 and visited the UK April 2022. This is when I realised - unexpectedly - that my allergies had all but gone. It was a complete and wonderful surprise.

[PBJ]

I am inspired by the improvements some have had in tinnitus and allergies. Those have been my two of my most annoying health problems.

[RapAdmin]

Really interesting. I also have had complete cessation of my my usual allergies during the spring/ pollen season once I started rapamycin.

I really started getting bad allergies (sneezing, runny nose, etc) in my mid-20s, and it continued for the next 30+ years until I started taking rapamycin, and then the issue went away entirely. When I’ve paused rapamycin for any length of time during the spring season, my allergies have come back.

[Joseph_Lavelle]

Allergy cessation is a new angle that would appeal to a large audience.

[Agetron]

I can vouch for the allergies being cured. Starting about age 50, I was getting allergies that I never had before in my youth… from Cedar in spring and Ragweed in the fall.

This is continue with needing a lot of flonase (was a prescription only when I first used it) used at the beginning of spring and in early fall…until a hard freeze.

Now, 3 years straight, using rapamycin have no allergies at all, so it has pretty much cleared that…taking me back to my pre-50’s resistance to allergies.

My sinuses are more moist and full now too.

[RapAdmin]

While we’re hearing some good results with rapamycin use for women who are potentially seeing a reversal of menopause as reported above, and in this thread: Women Taking Rapamycin for Enhanced Fertility / Menopause Prevention?

But, we are also seeing situations that suggest males may also receive benefit in fertility from rapamycin:

Male: stop rapamycin to have kids? How long?

This is very interesting, In my previous marriage me and my wife tried to have children without luck (ended up adopting the most wonderful girl in existence at birth, she is now 19 years old). During this time I tested my sperm and got very negative results back, very low quality and sperm count. I divorced about 12 years ago. I got a younger girlfriend in October last year, she is in her thirties and I am 54 now. She got pregnant in March this year. I was most surprised as I was convinced that I could never have kids. I have been on Rapamycin for 2 years (6mg every 2 weeks)

[RapAdmin]

from our forums:

A bit of advice to you older guys, basic life extension

After practicing Calorie restriction for six months and receiving incredible benefits, decided to try Rapamycin. The one thing I noticed immediately within a month was at times an overwhelming sense of well-being and also just a general better mood.

and another:

Has anyone used dasatinib+quercetin (D&Q) as a senolytic?

I take Rapa at 6 mg. every Sunday, Dasatnib (100mg.) + Quercetin (1200mg) for two consecutive days every other month, and 3gm of Taurine daily. I started with Rapa and Senolytics 3 years ago because of problematic osteoarthriitis limiting physical activity and other symptoms of chronic inflammation. Two years later my knees were 100% again (at age 63) and distance trail running in the hills again with my dog. In the past year, I added GlyNAC (3gm and 2gm daily) and Taurine (3 gm daily), but that was after two years with Rapa and senolytics only. My most recent blood test came through with a CRP less than one, my gum pockets (recent dental exam) are about one third the depth they used to be (common measure of systemic inflammation), and I have zero osteoarthritis when three years ago it was deblitating. My N=1 is the senolytics plus Rapa were a game-changer that gave me my life back (as measured by tangible pain and inflammation levels). Taurine and GlyNAC were only added after the drama…

[RapAdmin]

Rapamycin and Osteoarthritis

I am a 71yo male. I began to suffer from extreme arthritic pain in both thumbs when I turned 65. Reaching for a cup or coffee or pulling up my socks could cause me to cry out in pain. I started Rapa 18 months ago. After about 12 months I realized that my thumbs rarely hurt. I had forgotten about them. Rapa or coincidence? I am currently dosing at 10mg every 10 days. Only noticeable side effect has been occasional mild acne in my scalp. Blood work is seemingly unaffected.

[RapAdmin]

Rapamycin seems also to be helpful for people with Lupus (we’ve heard from multiple reports in our discussion forums):

Lupus and rapamycin

My wife suffers from lupus which has caused near daily debilitating fatigue, as well as heart, skin, and kidney damage among other troubles. After rheumatologists produced no effective help I researched other options and came upon rapamycin. After just one week of administration the results have been spectacular. It is startling to see her doing garden work for hours along with resuming all the activities of daily life. We are ecstatic. I was hopeful, but never in my wildest dreams did I dare hope for the full remission she experienced overnight. Without much to go on, we decided on a loading dose for her of 2 mg of Biocon’s Rapacan (Thank you, Jagdish and everyone who recommended you here!) on Day One then a schedule of 1 mg three times a week. Our dosing regimen for her is nothing more than a shot in the dark, however. Any experiences, anecdotes, or advice would be much appreciated!

[RapAdmin]

Saw this on Facebook today:

[RapAdmin]

Seen today in the Facebook Rapamycin user group. I concur with the sleep benefits - I see similar results.

[RapAdmin]

In the category of “Other types of benefits from rapamycin” - in this case epilepsy and autism:

Source: x.com

[RapAdmin]

Rapamycin for Arthritis:

For example, I have hand arthritis that had worsened over the last year. My PCP examined my hands and understood the extent of the problem. I summarized the lit on rapamycin and arthritis. My PCP proposed an experiment. She gave me the low-dose prescription I requested and we set up an appointment (and blood labs) leaving about 14 weeks for the rapamycin to show an effect. We were both astonished at the next appointment—my arthritis pain was greatly reduced and my range of joint motion increased a lot. This is a real quality of life difference for me—there are no effective approved meds for osteoarthritis.

Source: Rapamycin Prescription, Doctors that Prescribe It - #166 by Powe

[RapAdmin]

3 months into Rapamycin

3 months into Rapamycin 10mg per week 81 yrs old no adverse issues inflammation in wrists and hip greatly reduced toe nail fungus ‘gone’ noticeable energy and feeling of well being

[Paul]

Here is an interesting piece of data. I started rapamycin 5 years ago 12/2019 and have been taking either 6 mg weekly or 10 mg every 10 days since. Traveled south for a 30 day vacation in Dec but forgot to bring my rapamycin - so for the first time in 5 years I went without it. Since BJohnson stated that rapamycin negatively effects health I figured I’d get my annual blood work done before I resumed.
One (2 but related) results popped out. Had 5 years of data with poor kidney function out of range results. During 5 years all results were in range and suddenly I am back to 5 years ago

[John_Hemming]

What about Cystatin-C. Creatinine is strongly influenced by muscle mass.

[Paul]

yes, I will test this next time

[RapAdmin]

Is Delaying Menopause the Key to Longevity? (NY Times)

I’m 62. I got my period back after other biohacking things I’ve done, but my periods were not regular. On rapamycin they are now coming every month like clock work. And I can feel myself ovulate.

[Rob1865]

I have been taking 6mg a week for about a year through ageless Rx. I have lost some weight, but no real noticeable benefits. There was a mix up one month in my rapa delivery, so i wound up taking a week off and had noticeable weight loss the following week once i started rapa again. i was wondering who is providing the rapa to you that recommended 12mg once per week?

[RapAdmin]

Many of us here are just buying rapamycin from other locations (e.g. India: How to Get Rapamycin, Where to get a Prescription ) and testing different dosing levels. There is no really good data on what the optimal dosing level is for human longevity, so people test different doses and do blood tests to see if there are any negative effects of higher dosing. In many animal studies, higher doses result in greater longevity benefits (but there are risks, such as immune suppression, when you go to high regular dosing).