#1

Just had a physical, and my cholesterol is off the charts. I eat good and I workout with weights and run almost every day.
I vaguely remember Dr. Greene saying something about rapa & cholesterol. I checked AI: Rapamycin can cause hyperlipidemia as a side effect, leading to increases in total cholesterol and triglycerides. My triglycerides were high too.
I’m going to lay off for a while.

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#2

I think it affects most people. If you don’t have a low enough trough then over time it will go up. I think every other week is better for that reason. It affects fasting glucos too.

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#3

Well my TC has been high for 25 years but did not change with rapa. My trigs are quite low ~ 60

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#4

I’ve not seen anyone who has a “big spike” in either glucose/insulin resistance/HbA1C or in lipids. I’ve seen many have a small rise. However, most of my patients are on a selection of the following items:

  1. lipid management and we optimize
  2. Glucose management on a selection of acarbose, SGLT2-i, and/or GLP-1

In the end we usually see improvement in all measures.

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#5

Yah, increased cholesterol is a common side effect. I started taking 10mg Atorvastatin daily and it lowered my cholesterol beneath where it had been before Rapamycin

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#6

I think it depends on the individual. My lipids have improved marginally. Have you tested your Lp(a)? This is determined by genetics so you can find out if you have a greater risk.

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