I’ve been taking 250mg per day since May. From Amazon, $0.08 per pill so not very expensive. I haven’t had my blood tested since then, so I can’t report any results yet. But, my blood work was pretty good before I started taking it, so it may not be possible to detect any effect or to attribute any effect specifically to the Natto.
That is really great to hear, @Coachrhyk , and much appreciated detail. Thank you.
I’ve read in a few places that Nattokinase can be effective is “cleaning out” plaque from arteries and I’m happy it brought you back from the edge. Any idea what kind of doses of Nattokinase you might be taking daily in each November (or whatever your protocol is)? I’m curious so I can think about what a dose of pure Nattokinase for someone with an issue to correct is taking, and I can use this as an upper-limit to my thoughts of dosing.
Nattokinase is of interest to me because I am very curious if I can take a decent “artery plaque cleansing protocol” every quarter (or month, or year) to drastically reduce my risk of CVD even if I have higher LDL (which, absent the very-very-real CVD risk appears to potentially be protective in several other key areas). This and donating blood every six months and keeping rigorous (but not “endurance-level”) exercise should keep me kicking for a long time. (CVD risk is substantially lower with softer/elastic/plaque-free arteries and “reasonably-thinner” blood?)
I’ve been toying with the idea that, given my health is relatively good (and I feel great, and I get some good “up/down looks” from women in elevators), that I should be “pulsing” these protocols instead of a daily unaltering protocol I take for the rest of my life without deviation. For instance:
o. planning to take Rapamycin twice a month, and fasting for two days during my dose (maybe extend one of these fasts to four days as much as I can but not more than once a month and likely more like once every two months), but then not fasting and trying to promote growth/muscle/regeneration during the other times of the month.
o. Building muscle/strength with heavier protein and gym work for months, and then less protein periods with more hiking/stairs, cardio and lower/fewer weights.
o. Perhaps bouts of growth-inducing compounds such as GSK-Cu and BPC-157, and then rest periods in which I take Rapamycin. Etc.
This is because I feel (paraphrased by a doctor podcast which I cannot now remember) that each protocol has real trade offs, and if I “pulse” them (while keeping lean and healthy throughout) I can move two steps forward with each different “pulse” in multiple dimensions/axes even while I move one step back in each (because of the trade offs). But just a thought (there is no ITP for this protocol as far as I know).
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Soy intolerance is my why not. And if I were taking it it would be for a specific chronic health issue, because it was popular in chronic covid related conditions.
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I’ve been using Neprinol (I don’t want to insert link since I might get tagged as seeking something) which now is only serratipeptiase and amla.
Likewise, you can try to get your hands on pyridoxamine (not any other form) cannot be bought or shipped to us due to patent drug “infringement”.
Other things I did to clean out was IV EDTA. BUT THAT WAS ABOUT 15 years ago and have been fine since.
Good luck on your artery cleansing adventure!
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I took nattokinase for a month or so, but was also prescribed small aspirin by one of my doctors since I was on trt. I was worried about my blood thinning too much, and/or any possible hemmorragic effect taking both could cause.
I would ideally like to give it another try in lieu of aspirin but I’m not sure there’s enough research to support.
I do agree it should be given more consideration for CVD
My doctor loves Nattokinase and Lumbrokinase. He uses is for covid vaccine related injuries and claims it removes microscopic blood clots left in ones capillary system from spike proteins.
Flccc.net would have more information regarding that. Chelation therapy is an excellent option for the removal of plaque and calcium build up.
Good luck!
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If Nattokinase (and others) thin blood, would this itself be a positive beyond “cleansing” plaques from blood vessels? Many people take aspirin for this purpose and I don’t believe there are other benefits for longevity of aspirin (or really a reason to take it beyond thinning blood). So would replacing aspirin with Nattokinase be appropriate? If the issue is simply fewer platlets for less coagulation, this would be a good replacement.
I know many on this forum donate blood regularly to reduce iron levels and to recycle red blood cells more often (I believe — happy to be corrected) (and beyond the benefit of altruistically helping others). Would “thinning” blood replace the need for donating?
I assume there is always the possibility of too much of a good thing. Are there home tests for blood thinness? — for anemicasI would assume so. There are Prothrombin Time (PT)/INR tests which look like what they use. In the US they look like they are prescription only. But they simply measure coagulation. Is that what interests us in longevity? Is there a better test to use?
I am asking because using Nattokinase fascinates me, given my higher LDL, as a preventative measure for ASCVD and CVD in general (perhaps not constantly, and instead pulsed one month every quarter,/half etc.). Nice clean tween-level arteries would be nice. But I don’t want to inadvertently create a new issue (thin blood?) that I don’t currently have. So knowing where I am in the scale of physiology would be a nice thing before delving into a preventative biohack.
The link I found says Neprinol is Serrapeptase, Nattokinase, and Lipase - combined for 30,000 FU plus protease, anla extract, bromelain, papain, and coq10.
Do you take 2 pills per day for one month? 2 in the morning 2 at night?
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LaraPo
#29
I’m wondering if it could improve pancreas function/condition. I have hard time digesting fats.
I take 3x3 for a month annually. It also did wonders for a friend’s sister(anecdote alert!). She was late 70’s and chronic obstruction of carotids. Not given much of a survival chance. Five years later, she moved to Hawaii with new boyfriend and doing well with no stent required. I think she took it continuously for a few years. I really should follow up on her.
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and another anecdotal result here. Fifteen years ago my mother was similarly in her late 70’s and resident in a nursing home after suffering a stroke years earlier. The manager called me one day to say they were very concerned as her legs had turned almost black. Long story short - I signed off on Nattokinase for her (I seem to recall 2000 fu) and literally within days her legs had returned to a healthy colour and remained so until she passed a number of years later. The care home staff were astonished. I posted about it on imminst at the time but am unable to find the post now.
I have partially blocked carotids and have taken Nattokinase on an off several times with no improvement to be seen on scans …… no deterioration either though!
Incidentally, I remember reading that an md commented recently of youtube that he’d have no problem in recommending a combination of both aspirin and nattokinase since they work entirely differently.
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Bicep
#33
They didn’t use enough. Need between 10 and 12 thousand FU/day:
I don’t go continuous, I have a couple bottles, then wait awhile.
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Thank you, @KarlT, much appreciated: not the rousing endorsement I had hoped for. The doing and timeframe appear to be roughly at what @Tomnook ’s mother took, albeit when she was 85 (?) and already highly compromised. I don’t know how to match @Dexter_Scott ’s 250mg per day with FU per day so no idea if this is in range.
Based on the Chinese study I had referenced above with the highly positive results they used 10,000 FU per day (although being a Chinese study to err is a high probability it is a) faked data and/or conclusions, b) incorrectly obtained/interpreted data/conclusions, or possibly correct) — 5x what the null study @KarlT referenced. (Paper here, but also the first post in this thread: Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - PMC )
I’ve been contemplating using this as a “pulsed” treatment once per quarter/half/year so higher dosing is expected.
Here is the text from the @KarlT referenced paper abstract explaining their methods and conclusions:
In this double-blinded trial, 265 individuals of median age 65.3 years, without clinical evidence of cardiovascular disease (CVD) were randomized to oral nattokinase 2,000 fibrinolytic units or matching placebo. Primary outcome was rate of change in subclinical atherosclerosis measured by serial carotid ultrasound every 6 months as carotid artery intima-media thickness (CIMT) and carotid arterial stiffness (CAS). Additional outcomes determined at least every 6 months were clinical parameters including blood pressure and laboratory measures including metabolic factors, blood rheology parameters, blood coagulation and fibrinolysis factors, inflammatory markers and monocyte/macrophage cellular activation markers.
Results: After median 3 years of randomized treatment, annualized rate of change in CIMT and CAS did not significantly differ between nattokinase supplementation and placebo. Additionally, there was no significant effect of nattokinase supplementation on blood pressure or any laboratory determination.
Thank you, @Bicep. This was the paper to which I have been referring. And I agree it is the 10,000 FU dosing (or higher) which appears to be best in the “pulsed” treatment that we hear from doctors prescribing this. But it’s starting to make me nervous that I’m basing my thoughts on a single Chinese research study, albeit with a U.S. doctor involved, and for a larger number of participants.
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KarlT
#36
@Bicep interesting study. Thanks. A bit concerning that they eliminated 65% of the participants. I will have to look into this more.
@Ericross2 I think 100 mg = 2000 fu
It would also be nice to see more info on side effects. Most articles pass it off as harmless. I’ve found a case report of an elderly woman who died of internal bleeding.
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Bicep
#37
In Lustgarten’s book he talks about the important jobs that LDL and Fibrin have in defending the body against the microbial burden. So killing all the fibrin probably is not brilliant. It’s there for several reasons. That’s why I go in spurts.
I can’t make my kindle app work with his book any more. I’m a little tech challenged. I should see if I can just buy a paper version.
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I don’t know how to match @Dexter_Scott ’s 250mg per day with FU per day so no idea if this is in range.
The pills I am taking are 2000 FU. Guess I need to take five of them instead of one per day. 
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I don’t know about fibrin, but LDL causes way more harm than benefit (if it does have any). Otherwise statins wouldn’t decrease all cause mortality.
The Chinese study said 10,000 FU per day, so if this is your guide, you’ll need 5 pills per day instead of one. I’m less likely to base my own supplement stack change in one Chinese study. And 10,000 per day every day for the rest of your life seems high to me from a risk perspective (without harm/risk studies to back this up). But it seems there is anecdotal evidence (usefulness questionable?) of “pulsed” higher dosing for a month per year, or a month every 3/6 months, so I’m likely to try this instead. I’d also like to get a full work up before I start so I have a baseline. And if I notice adverse effects during the “higher pulsed periods” I’ll stop. But having clean clear arteries seems worth the trouble, especially with my higher LDL.
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