There is a LOT of very poor advice/science to go over here.
If you’re buying “retail” rapamune, you’re getting it from actual pharmaceutical manufacturers. These manufacturers will put preservatives, stabilizers, and other such vital ingredients to stabilize rapamycin, prolong its shelf-life, and increase its bioavailability.
Furthermore, they will also have the enteric coating which allows for bypassing of the gastric acids and dissolving in the small intestine. I’d say, if you can acquire retail rapamune or some other tablet form, your quality is assured. A direct pharmaceutical product will be leagues better than what anyone can possibly homebrew.
Oh dear…
For one, micelle solutions are very difficult to brew at home; you won’t be able to do it. And no, micelles are not just “soap,” at least not the ones used in pharmaceutical science. There is a very careful balance between forming micellar suspensions and inducing hemolysis in your veins.
Second, you need to ensure as sterile an environment as possible. This is indeed possible at home, but I wouldn’t recommend making your own rapamycin injections it since it’s completely uncharted territory. That’s just my usual disclaimer, though.
I hope you aren’t attempting micellar injections at home, but if you are, forget the micelles. They don’t do much to suspend rapamycin anyways. In the interest of harm reduction, you should refer to MAC’s thread regarding injections and specifically the guidelines I’ve laid out.
As a side note, micellar solutions are typical for IV injections, not IM or SC. Please do not attempt IV injections at home. If you’re going to inject, please just do IM or SC, as an IV injection can go really bad, really fast. Especially if you screw up the dose. Homebrewing tends to be very inaccurate if you don’t know what you’re doing, and I’ve seen plenty of cases of miscalculated doses leading to severe consequences.
Yes, you can make your own tablets. But no, you won’t ever reach the quality of a “retail” product. Again, you’d be attempting to recreate as a single individual something that billion-dollar companies do in their sleep. Their quality controls, testing, equipment, ingredients… all of it is hyper-space compared to what can be made at home.
Again, as others have mentioned in this thread, cheap chemicals can fuck you up.
Pharma can acquire high-quality, near-pure reagents and ingredients. We typically cannot. This is especially true for cheap chemicals, where the quality is almost assured to be bunk. For instance, many pharmaceutical chemicals can be contaminated by formaldehyde, especially ones from the shady Chinese or sketchy Indian sources.
But why formaldehyde? Well, it’s quite a useful chemical in organic chemistry, used typically as an alkylating agent.
So, buying pharmaceutical chemicals from dirt cheap sources might be detrimental to you in the long run. I value my health highly, and as such I’d rather pay good money for a high quality assurance rather than try to save a buck and end up poisoning myself. This is one area you do not want to cheap out on. You can try to save money here and there, but cheap things are cheap for a reason.
Yes, there are a lot of homebrewers out there. However, a LOT of them are doing it horribly wrong. Nonsterile injections, botched formulations, dosages that are “eyeballed” and lead to catatonia… yeah… I’ve seen a lot.
This is why I always recommend oral and not injectable. Oral is very hard to mess up. Best case scenario if you do, is you get the wrong dose and maybe an upset tummy. Worst case scenario is only achieved if you do something ridiculous like chugging a whole bottle of medicine.
For injections, however, it’s like tickling the dragon’s tail. Sure, you might be fine most of the time. But when things go wrong, they go wrong.
