#406

I’ve been taking asta for 10+ years, and have been taking about 100mg / day for the past 4 years. This thread is making me even more bullish on it. What a wonderful supp! The claim that human dosing req to equal mouse dosing is 1-2 orders of magnitude less, even after adjusting for allometric scaling, is quite a revelation. I might lower my dose a bit.

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#407

Genja, what brand are you taking? The effectiveness of 100 mg can vary significantly between brands due to differences in absorption rates. Some brands with superior absorption might deliver the equivalent effect of 100 mg with just 20 to 30 mg of the active ingredient.

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#408

Microingredients. I think they have been 3rd party tested and passed.

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#409

Since AX3 isn’t sold on Amazon, I won’t use it. It’s too logistically annoying to use non-Amazon supps. Just will take higher dose of microingredients.

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#410

I did further reading and this was successful for men but not women. Unfortunately- since I like astaxanthin!

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#411

I did not expect that! Was it the same study that I posted about plaque formation?

#412

Sorry was an article I read independantly yesterday…was reading on astaxanthin as a PCSK9inhibitor I think (looking into natural ones) am post menopausal woman so was disappointed asta didnt work as well as for men re lipids.

#413

Carotenoid Interactions with PCSK9: Exploring Novel Cholesterol-Lowering Strategies

Quote:

“Conclusions : These findings provide evidence that specific carotenoids, particularly astaxanthin, may offer a cost-effective alternative to existing PCSK9 inhibitors, providing a potential approach for managing cholesterol levels and reducing cardiovascular risk. Pre-clinical and clinical validations are required to confirm the therapeutic potential of these compounds.”

Please note of course that astaxanthin at doses commonly taken by humans, does not appreciably lower ApoB/LDL and certainly not to the extent existing PCSK9i drugs do.

Whatever the speculation in this paper (and maybe the article you read was based wholly or in part on this paper?), the purported effect of astaxanthin on blood lipids is not even in the same zip code as actual PCSK9i drugs.

IOW, nothing to see here - and I say that as someone who supplements with astaxanthin 12mg/day-5. I don’t take it because I think it’ll lower my lipids though, lol. YMMV.

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#414

men need all the help they can get to catch up with women’s lifespan

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#415

What about other natural PCSK9 inhibitors? It might be worth a shot? My doctor recommended berberine with bergamot, add on melatonin eg.

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#416

PCSK9i drugs lower ApoB/LDL and have been approved by the FDA for CVD related pathologies after extensive trials. None of any of the other supplements you have listed show the same effect and none of them have undergone the same kind of trials for that indication and none have been approved by the FDA and when you buy those supplements they have a legal obligation to state that they do not cure any disease or condition. Why do you think they make that statement? Take their word for it.

I am not a doctor and offer no medical advice. Your doctor can offer any advice s/he wants. What s/he cannot do is show any trials of those supplements like FDA approved PCSK9i drugs. Make of that what you want.

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#417

If I recall, you want statins or another prescription cholesterol lowering medicine, but your doctor refuses to give them to you. Is my bad memory correct?

If this is the case, instead of going down the rabbit hole of supplements that won’t do much, if anything at all, have you considered simply ordering statins, bempedoic acid, and/or ezetimibe from the sources many of us order from?

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#418

Hi in Australia (Perth) my GP told me that they do not usually prescribe medication for cholesterol thats less than 10 (mine is 5.6) or low thyroid TSH less than 10 either (mine is 6.71) . Both up from the previous year. Plus he and my endo told me that both higher rates (not yet clinical) are in fact protective in older age. I am 64. So past 5 years I have just had yearly bloods thats it - told to take bergamot, berberine and two brazil nuts a day. Last visit he acknowledged that the low thyroid could be a factor and suggested levo 50 mg. So far I have not taken because it was my suggestion and I do not feel as though there has been a thorough evaluation of my health. Its fine I now know I have Lp(a) insisted to be tested even though was told that is not usually tested and I paid extra to get. Next I see a cardiometabolic doctor because I have now informed myself.

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#419

Just take it with a high-fat meal and you’ll get good absorption regardless of brand. I’m sure the study used fasted volunteers, which is the only case where the pill formulation is going to make any difference.

1 Like