Jonas
#1
Per Aubrey De Gray’s post today on FB: the all-treatments group is still taking roughly twice as long as the all-controls group (starting from 19 months old, when the experiment began) to get down to a given survival percentage in males, albeit only about 50% longer than controls in females.
Bottom Line: the effect appears to be stronger in males who lived twice as long as controls, compared to females who lived only 50% longer while all 4 interventions extended lifespans. (so If Males lived 2 yr vs then Females lived 1.5 yr compared to controls, relatively speaking).
Interventions:
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Guess being born a guy has its perks after all.
José
#3
If you are a laboratory specifically bred mouse.
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Neo
#4
Actually even
If you are this specific laboratory bread of mouse.
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Neo
#5
Are you looking at the Feb 3 update? (Or is there a more recent one than that)?
José
#6
Mice that where used in the study.
Mouse Strain: “We have selected pre-aged C57Bl/6J for the first study on the basis of availability, and in order to match other lifespan studies involving the interventions employed here. The second study in the RMR program (examining a different panel of interventions) will probably be conducted in HET3 mice; this strain may be a more representative model of human aging, and will provide a valuable direct comparison to data from the NIA Interventions Testing Program. Subject to funding, we expect to be able to source a sufficient population of pre-aged HET3 mice to initiate the second study from Jackson Labs by Q3 2023.”
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Jonas
#7
Today on FB posted by himself
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Jonas
#8
Females are doing really bad in RMR, if Claude says to be true: “I am quite confident that in the C57BL/6J mouse strain, female mice tend to live longer than male mice on average. This is a well-established finding in aging research using this particular inbred mouse strain.”
But per Gemini and ChatGPT, Yes, research suggests that male C57Bl/6J mice tend to live longer than females in pre-aged conditions. Studies have shown a statistically significant difference in lifespan, with males living around 13% longer than females on average [2].
So much for AI. Need double check on everything!
And per this: Austad and Fischer [28] recently reviewed 29 studies on the C57BL/6 mouse strain and found that males lived longer in 18 studies and females lived longer in 11 studies.Jul 29, 2019
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The males of this strain of mice live longer than females. Dr. Miller calls this a ‘trash’ mouse. They should have used the ITP HET strain for better results.
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