#21

Didn’t feel any different. In fact, nothing I take makes any noticeable difference with the exception of glycine, which makes me feel depressed.

2 Likes
#22

Wow. Glycine makes me sleepy but feel good. Sorry that you have such a negative reaction. I guess it’s true about our biologies being very different!

2 Likes
#23

Do you take NAC and Glycine in separate capsules at the same time or do you mix powder together?

#24

Yes, we’re all different. I have a history of mental illness in my family, although thankfully, I’ve been spared. Interestingly my genomic report from Nebula nailed the specific diseases that run in my family. I have a really high predisposition to these diseases, which just goes to show that your genes aren’t your destiny.

Newly Discovered Trigger for Major Depression Opens New Possibilities for Treatments - Neuroscience News.

I was taking NAC and Glycine for a few months and was just feeling awful, unmotivated and down. I took a break for a while and started feeling better. It’s possible it was a placebo, but I don’t want to test it again to prove it for obvious reasons. I’ll still take it occasionally, if I’m extra tired-sleep is a still a big issue for me - but I don’t take it more than a couple of days at a time.

4 Likes
#25

That is definitely NOT good. Interesting to know if anyone else may have noticed same?
If it were to be 10% true my whole 1kg I bought a month ago is going into the garbage bin and very fast. Last thing one wants is to feel depressed (especially now at winter time)

#26

I wouldn’t throw away your glycine because of anyone else’s experience. We have different physiological responses to certain molecules and until you try them you can’t know. Also, it’s very hard when doing N of 1s to separate subjective feelings from any actual real results. That’s why we have the scientific method. We’re notoriously bad at this stuff.
I always tend to err on the side of caution and there are some molecules I’ll steer clear of because I can’t convince myself there’s enough evidence to support it, but that’s also based on my very limited understanding of the science. For example. I won’t touch lithium because it’s a mood stabilizer used in Bi-polar disorder and I’ve seen what it does at clinical doses. However , theres some evidence suggesting lower doses improve cognition and might extend lifespan. My own personal bias prevents me from trying it and I have to admit there’s nothing scientific in my decision. A little knowledge can be a dangerous thing. Best thing to do is try it and see if it works for you, glycine seems to have a positive effect on lifespan and mood in many people. You could be one of them.

2 Likes
#27

I haven’t seen any benefit whatsoever for last month or so taking it. I haven’t noticed anything bad either. At some point I thought it was slowing metabolism, but then again might have been anything else I’m taking. I sometimes feel we are chasing our tails on these forums lol. Been trying 5-10 new things based on info on these boards to later find out that there could be some side effects (serious in some cases). I am at a point of scrapping everything and stick with less than 10 things. I even tried methylidene Blue which I now think it is worse than useless unless you have live worms living inside you lol. To be perfectly honest I think I’m about 5-10% worse off now that I am taking about 5-7 new things (based on these boards) than how i felt before (taking usual vitc, lysine, vit d3, k2, zink, boron, iron, rapa, metformin, and 3-4 other supps, plus cycling them regularly). I’m starting to think that less is more with regards to meds/supplements and stick with other tried and true methods such as Fasting, calorie restriction sub 1800 a day, heavy exercises, cold and hot showers, sauna, little to no sugar etc…

4 Likes
#28

Apparently, I am a non-responder to most supplements. I take a lot of glycine daily, 8 -20 grams, along with NAC, and I feel absolutely nothing from taking them

5 Likes
#29

I have a feeling you’ll live to 100 with or without expensive urine.

1 Like
#30

Thank you. I hope to see you at my 100th birthday celebration! :slight_smile:

1 Like
#31

I’ve been increasing my glycine, taurine and NAC (for cysteine) based on multiple reports and articles. I’m not up to these levels but it seems reasonable to try.

As an aside, I’ve been adding glycine and taurine to my elderly cat’s diet, probably in comparably high doses to yours. I cut the powders into her wet food then add a squirt of Omega-3 fish oil.

It seems to really help her - her appetite has improved a lot (even for her dry food), and she’s gaining needed weight. At her last check-up her kidney function is very good for her age (it was decent before starting this but at least these supplements aren’t harming her)

2 Likes
#32

I’m similar. Except for a tiny number of rather dramatic exceptions (eg, niacin) I feel nothing, and take these more on faith than results.

I have occasionally seen results in blood tests - for example thyroid T3 seemed to do nothing but I later found my normally high cholesterol was too low (yes I’ve mentioned this before, if it seems I’m repeating myself). But otherwise I really have no clue if they help or not.

1 Like
#33

Just don’t eat too many, one can quickly overshoot and get too high selenium from them

1 Like
#34

Is this a specific medical need? This may not be pro longevity

#35

I eat two Brazil nuts every day. They say that 1 or 2 Brazil nuts is all you need to fullfil your daily requirements for selenium.

I think it was discussed in this video:

4 Likes
#36

No, not that I’m aware but heard we need to take it. Are you sure Iron shouldn’t be taken unless we are deficient? And how about zinc, copper, boron? I take these 3-4 times weekly. Never felt anything good or bad from any of these elements.

#37

Too little and too much iron is bad. Iron accumulates and generally does not get lost (without blood loss, for the most part) so accumulation is the primary worry for me (male). Of course diet matters. I eat a lot of animal muscle so I donate blood several times a year. I would never take iron supplements unless I knew I needed it.

4 Likes
#38

Interesting, I eat 2 per week due to living in Northern Europe with selenium deficient soils but selenium content is variable depending on where they are grown so 1 to 2 per day could be the right amount if they are on the lower end of the range. From my understanding selenium is a Goldilocks mineral where too much is as bad as too little.

3 Likes
#39

Just to agree with Joseph ferritin at the lower end of the normal range appears to be best for health as ferritin is a pro-oxidant. I shoot for around 50ng/ml but am relaxed about going up to 100ng/ml. Lower could be even better but there is a trade off below 30ish where your hematocrit may go down along with exercise performance. If you are a male or a post menopausal woman you probably should check your ferritin before taking iron supplements.

Copper and iron are obviously found in amyloid plaques in the brain but whether high copper blood levels are causative I don’t think is known. My opinion is don’t supplement minerals unless you are low on a blood test but to each his own.

2 Likes
#40

For what it’s worth, Dr. Sinclair stated that increasing iron also increased epigenetic age. Not what we’re looking for.

4 Likes