A very good podcast on the history of rapamycin:
Other very good podcasts covering the science of health and longevity:
Stem-Talk also has many good episodes with scientists studying aging:
A recent (Feb, 2020) podcast from The Guardian:
A podcast by The Economist magazine:
The Longevity Biotech Show:
Human OS Podcasts:
Nutrition Facts with Dr. Greger
https://nutritionfacts.org/audio/
Which podcasts are your favorites? Please add them below in the comments.
7 Likes
Sandra
#2
David Sinclair new podcast should be added to this list.
2 Likes
Boldi
#5
Iām listening to it, but really struggling with how much to believe. When, say, Matt Kaeberlein or Peter Attia say something, I trust that itās a mostly clean representation of current knowledge. But with Sinclair I really struggle to parse out what is reproducible science and what is hyperbole and wishful thinking. Does anyone else have this hesitation?
3 Likes
Yes, i have followed David Sinclair for over 15 years (started following the Guarente lab back in the dayā¦). None of the compounds David has focused on seems to have panned outā¦ Resveratrol, Sirtris small moleculesā¦ and now the NAD/NMM stuff, that still hasnāt shown any significant life extension effects in third party labs (that Iām aware of).
So yes, his actual track record is not so great. Few of his results seem to be reproduceable.
I think the issue is that he typically has some sort of commercial interest in the outcome , so has a tendency to overplay the results (which is just human nature, and is the problem behind conflict of interest, even if they are identified - nothing nefarious).
I find his analysis in areas he doesnāt have a commercial interest to be much more accurate (i.e. on rapamycin).
Neither Peter Attia or Matt Kaeberlein have much if any financial interest in the most interesting small molecules / aging therapeutics that they focus on - which seems to be a good thing, and makes their information much less biased and skewed (in my opinion).
6 Likes
This seems to be a reasonable summary ā¦
2 Likes
I do enjoy Dr. Brad Stanfieldās youtube videos. They really got me started on longevity along with Dr. Sinclair. I think Dr. Brad gives advice he believes in. I also enjoy reading Dr. Sinclairās Twitter feed.
Another couple of longevity youtube channels I enjoy
3 Likes
tongMD
#9
Yep, that has been the summary of my findings too, but to be clear - I have not read every single resveratrol paper out there. Sirtuins are real and replicated in other labs though.
I think there is also still a possibility that there is some other factor in a polyphenol extract of grape skin in a huge amount of resveratrol that may be needed as a combined SIRT1 activator. I havenāt seen anything yet but thatās just a hunch from very weak evidence in the āFrench paradoxā studies, so I think itās still a possibility to look for IMO. Iām not taking any resveratrol currently though and never have. But I canāt say for sure I never will when thereās more evidence.
My gut feeling is an overwhelming majority of people just see Harvard and donāt actually read research papers in depth. Iāve seen enough to avoid using brand names as a heuristic (i.e. case in point - Theranos founder went to Stanford) instead of actually doing the hard work of independent research. Nothing against Harvard - Iāve lived in Cambridge before and my dad managed clinical trials in the Harvard-MIT complex before - tons of great researchers overall.
2 Likes
NUS National University Of Singapore
I donāt think that they are in podcast form but they do have interesting talks by guest lecturers that I find on YouTube and Brian Kennedy is there.
2 Likes
Ah yes - the NUS Singapore Medicine Youtube channel - good stuff:
Ray
#12
Not directly related to longevity, but I found this interesting;
ACE inhibitors such as Enalapril when combined with Nandrolone may reduce or eliminate the risk of heart damage from the Nandrolone. Some interesting studies are skimmed over in the video.
1 Like
