#369

I’ve never really understood the logic of cycling anything to be honest.

1 Like
#370

There are good reasons for cycling such as the difference between catabolic and anabolic phases.

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#371

It’s possible that we evolved around seasonal nutrient availability and intermittency.
In ancient Northern Europe even sufficient sun exposure to produce vitamin D was seasonal.
Winter months were marked by cold exposure, maybe pickled products (probiotics), some meat and fasting.
Summer months - fresh fruit and vegetables, occasional meat, Sun exposure for vitamin D
Fall months - add mushrooms
Occasional honey if a hive was found.
etc

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#372

I don’t buy the idea that Rapamycin is catabolic. I understand people are basing that theory on the mechanism of it lowering mTOR but we haven’t seen catabolism in any of the data (in fact we have seen the opposite)

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#373

I look at it like this. No one is coming off their blood pressure medications or statins to reap the benefits of cycling because they know the benefits will quickly go away once they stop taking them. I don’t see why anything else would be so different.

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#374

There is no reason why we have to agree on these issues. My understanding of rapamycin is that by inhibiting mTOR it increases the recycling of mitochondria (mitophagy). That is catabolism.

However, there is no reason why you need to agree with me.

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#375

I agree with this, and I view all disagreements here as educational. I’m open to agreeing with you if I see something compelling enough to make me change my mind, which happens a lot on this forum.

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#376

Hypertension and hyperlipidemia are serious medical conditions that need to be kept in check. It’s sort like we need air and water daily as well.
However for most of the allergic diseases we use seasonal and intermittent use of medications to minimize side effects.
Supplements are hardly that necessary.

BTW, Big Pharma would prefer that you take medication daily because it is way more profitable. A lot of their studies are set up for daily use. Sometimes that makes sense and sometimes it may not.

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#377

@John_Hemming have you never had concerns about the potential ‘rebound effect’ taking such high doses intermittently - a number of papers suggest may occur?

#378

Safety is the reason to cycle it. If taking it daily, one would be mTORC1 inhibited all the time, which will result in immunosuppression, but also make if very hard to gain/maintain muscle.

The improvement in lean body mass is going to occur in recovery from mTORC1 inhibition.

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#379

To be clear, I’m talking about intermittent Rapamycin use (every 1-2 weeks) and not daily. I know daily is probably not a good way to use it for longevity. I view “cycling” Rapamycin as taking considerable time off (months for instance).

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#380

Excellent - then yes, I agree as I don’t see a huge reason to be on rapamycin then stop it in regard to reaping better benefits from that approach. As with most things duration of therapy (if effective) is key to get benefits. I appreciate others have a different view.

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#381

See my post above. I think my message about cycling was a bit unclear. I wasn’t referring to taking Rapamycin on a daily basis.

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#382

In the end I have to be a bit self interested in this. If I find doing my own measurements that I am getting the outcomes I wish to get then that achieves what I wish to see.

I cannot be certain that everyone else will respond the same way. There clearly is a sort of rebound effect if you look at the results I posted on this forum.

Hence initially there is hepatic insulin resistance, my body adjusts to increase insulin there is then a rebound as glucose handling gets tighter.

At the moment I am a little concerned that my WBC is lower than expected (It is normally low). However, I think that is winter infections rather than rapamycin. Hence I did not take rapamycin as I planned to in early december and am intending to run a CGM session before taking it again.

It is not surprising that there are more infections around during the colder weather. Arguably that is a good reason not to take rapamycin.

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#383

I’d never argue with you as the complexity of your answer will make my brain hurt.

I would however point out that most of the winter seasonal infections are viral. Rapamycin seems to help T cell immunity when cycled. I appreciate the survey Matt K did, and they noted less bad outcomes with covid, which is exactly what I’d expect. So winter might be the perfect time to be on rapamycin?

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#384

Rapamycin clearly reduces the number of wb cells. It probably makes them more efficient.

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#385

The problem that I have faced here in Hong Kong is that many infections start off as viral but then progress to bacterial. I used to get chronic phlegm and coughing that would last months on end. After starting supplements and Rapamycin, the cough and phlegm would only go on for a month. After getting my flu vaccine this year, I have avoided getting sick so far!

I’ll be getting a flu vaccine every year now. :grinning:

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#386

Blagosklonny (God rest his soul), advocated weekly Doxycycline 100 mg. A very low antibiotic… for all that little crap hiding in your body… doing slow… but steady corruption.

There are those that say it can affect gut biom, but I think this day and age… I will go with cleaning out parasites and other harmful crap.

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To clarify… 1 pill that is a 100 mg weekly.
But good to have extra on hand too… should a mild skin issue occur. Take a few daily until skin heals.

Been doing this a few years.

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#387

I followed the advice of @Agetron on this and have been taking 100mg Doxycycline once per week for a few months now. I can’t say I’ve noticed any positive effects but I certainly haven’t experienced any negative effects either. It seems like a pretty safe insurance policy.

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#388

Rapamycin is not a toy and it does not forgive traitors

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