#389

Hahaha… exactly. Well said.

Andriy is typically a Ukrainian man’s name. Descendants from there?

Just saw this on the news…

Following Elon Musk tweet, Ukraine’s outgoing ambassador to Germany, Andriy Melnyk , sharply replied to Musk. “F**k off is my very diplomatic reply to you, Elon Musk,” he said.

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#390

I think it is far more forgiving that you think… I dose up 20mg weekly for a few weeks until I realised that my blood test was off the charts… Anyway today I am starting on 3mg a week for a few weeks and will be getting my blood work at different times to see what it is doing.

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#391

Just say’in - I tried a high 20 mg + dose for 7 months - TBH… I didn’t feel too different, but felt I was beginning to lose a feeling of health.

Found out through testing that my biological markers were significantly harmed - i.e. was aging faster.

I would have thought I could feel that much change - I didn’t. Very sublime.

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#392

Thanks for sharing.

  1. What are the biomarkers signifcantly harmed?
  2. How are you dosing now or you have stopped?
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#393

Hey Jonas,

Using GlycanAge test… I was able to check my body inflammation levels… mine were at a typical 37 biological years person… that was after 3 years of rapamycin at 6 mg weekly.

When I shot the dose up to 28 -36 mg for 7 months my inflammation was that of someone 51 years. Good for someone 65 years at the time… but had been 14 years better.

Next, TruMe Labs DNA METHYLATION test had me at 52…I spiked 3 years to 55 years.

I reduced back to 6 mg weekly dose and after 8 months, I was measuring biologically close to my original great numbers. My anti-aging benefits returned.

This is why I am bullish about the idea of higher dosing… It can quickly harm. I think 6-8 mg weekly is the sweet spot for men. Maybe 4-6 mg weekly for women… who seem to need less.

I have been on 6 mg weekly for most the time.

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#394

Thanks. Check out the new RMS on the other threat.

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#395

By RMS - you mean use of Rapamycin (Temsirolimus) for treatment of Rhabdomyosarcoma? Impressive.

Link: Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies - PMC

Link: Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model - PubMed

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#396

As John Hemming said anabolic/catabolic phases are how muscle is maintained.
We cycle sleeping and waking, among many other things.

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#397

I have CFS, long covid etc. Often crash due to exertion (this may involve getting sick with a cold or bacterial infection once or twice a month with longer periods of recovery and resting.

took 1mg with grapefruit initially. Then stopped. Paused for a while. Attempted to take just 1 to 2mg with OO without grapefruit but was getting a variety of skin and tissue problems. Then stopped last year. Not sure whether I should somehow continue.

I noticed some people taking 4mg a month. Maybe I should try 1mg a month. It could be too low for any useful effect?

#398

Where is the discussion of paper’s weaknesses?

#399

B. Johnson has a new YouTube video out on this very topic, in case you missed it…

“I made myself older by mistake”

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#400

Rapamycin made Brian’s epigenetic age worse. It made mine better by 7 years. I wish I had measured my RHR before and after, but that’s too late now. It seems like it doesn’t make a difference for me. So, if RHR is more important to him than the longevity data in clinical animal trials then that’s up to him.

His clickbait is annoying though as Rapamycin is in no way poison. :frowning:

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#401

Because I take Rapamycin really infrequently I can see my RHR go up and then back down again. Therefore I don’t see it as something to worry about.

Biomarkers vary in a number of different ways. One challenge is to work out actually what you want to see given all the circumstances.

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#402

Again, as Matt Kaeberlein said, it is good that BJ is against rapamycin, because if he were for it, as before, rapamycin would be associated with BJ, which is not what you want. BJ is on thin ice long term, should he go down in flames one day, rapamycin doesn’t suffer reputationally by association. Now rapamycin is free to make its own bones, and rapamycin users can take it with no fear of being connected to BJ.

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#403

I am not sure I agree with you on this. I don’t think that BJ’s credibility will reflect on anything other than things where it is only his credibility that has an effect. Rapamycin will stand or fall on its effects for people more generally.

I remain of the view that anyone who is using hair die and botox for longevity purposes is not really concentrating on the science. My own personal priority remains the science.

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#405

Where did he say this, do you have a quote?

#406

In the whole video he keeps saying Rapamycin made him older. The only way this is measured is with an epigenetic test or Dunedin Pace which is also epigenetic.

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#407

If that’s the case it shouldn’t be hard to find a quote where he said rapamycin made him older.

#408

Bryan stopped taking Rapamycin after this study suggested limited benefit at higher doses and his own data showed disrupted lipids and cholesterol. His frequent dosing likely inhibited both mTORC1 and mTORC2, leading to metabolic side effects. The study reinforced that low, intermittent dosing may offer the best trade-off between longevity benefits and safety, and the attached image suggests the same. Am I misreading or misunderstanding this?

IMG_2862
IMG_28621140×780 193 KB

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#410

I watched the video as well and he never said it made him older, especially not epigenetic age. I asked you for a quote, you didn’t want give one, okay.