#624

No. I already posted all of that above in two different posts including two articles. Only Bicep clicked on the first article and no one on the second as of the time of this writing.

#625

No I did look at it.

#626

I had my microchip update today with the updated Pfizer vaccine. Also got the flu vaccine in the other arm as a bonus.

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#627

They were called out by their own people including their own co-founder. A third of their board resigned. That’s one of the reasons why it’s so scandalous. That quote from the linked article above (also below) was from Dr. Tom Jefferson, one of Cochrane’s most distinguished members, and actually using the word “garbage” to describe some of their reviews.

“The contention that Cochrane has been publishing reviews that are mainly beneficial to the sponsors of these interventions is probably a fact,” says Jefferson. “If your review is made up of studies which are biased and in some cases are ghost written or the studies are cherry picked and you don’t take that into account in your review, then its garbage in and garbage out – its just that the ‘garbage out’ is systematically synthesised with a nice little Cochrane logo on it.”

That creates a problem when you have an organization reputed to be the pinnacle of integrity and professional excellence.

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#628

Yes, it’s funny, isn’t it, when big pharma and funding organizations with deep pockets are accused of slithering their way in to manipulate reviews of the safety and efficacy of medicines and vaccines that can impact the lives of millions of people? Ha ha?

‘“Cochrane has become too sensitive to criticism of the pharmaceutical industry”, says one board member. Insiders say a ‘possible concern’ might be that Cochrane fears that Gøtzsche’s criticism of the HPV vaccines review would negatively impact its sponsorship from the Bill & Melinda Gates Foundation.’ (Source)

#629

This is bickering, I find it unlikely anyone finds this relevant to this thread about Bryan Johnson’s protocol. We all understand you are passionate about this issue, but very few others find it interesting or meaningful. You aren’t linking Cochrane’s response to that BMJ article, so I doubt you have made a proper analysis of this issue.

Taking some quotes from an article is completely meaningless, you haven’t put in your own words your own analysis…

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#630

This is what you wrote above:

“This is bordering on gossip, if you have a clear argument with evidence, that would be interesting to see…”

I gave you what you asked for. And as far as I know, you don’t speak for everyone here. So please don’t post lines like, “Nobody is going to read and analyze your linked article.” Just speak for yourself.

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#631

We all? Again, please speak for yourself. The forum owner posted a comment that, “Yes - generally Cochrane reviews are considered the gold standard.”

I posted a dissenting view to that along with reasons why and links. And that’s fine. And you were actually the one who asked me to. And I don’t have anything more to add.

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#632
#633

This forum, which I enjoy very much but nevertheless, is loaded with threads that get derailed and seldom does anyone get called out on it. Sometimes I find it frustrating but other times such as this it becomes interesting. Personally I found Vlasko’s information about Cochrane very interesting.

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#634

Assuming there were bias in cochrane reviews, can you find other reviews or even single rpc trials showing that the use of statins directly impacts male testosterone levels? Then we can talk further.

#635

Data from the UCSD Statin Study previously showed that statins significantly reduce testosterone in men, with magnitude of drop related to LDL-drop on simvastatin and to HDL-rise on pravastatin.

https://www.ahajournals.org/doi/10.1161/circ.130.suppl_2.13926

#636

And funny enough this debate ignited in the BJ protocol thread. In his protocol he tries every possible thing to live as long as possible and has a team of scientists behind to choose interventions but he is not taking any lipid lowering medicines and while he is very concerned about his sexual health, which includes prostate and is obsessive about cosmetic appearance of his hair he is not taking any 5a-reductase inhibitors. I wonder why.

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#637

No, read my post what I was responding to. You can press the small arrow with your name.
image

I have near zero interest about Cochrane bickering. You will see that I was asking about testosterone.
So it might’ve been a simply misunderstanding…

#638

Maybe @RapAdmin we split a general discussion about Cochrane into its own thread, and then we can continue with the astraxanthin discussion in this thread? I personally didn’t see issue with it, although the longer the “discussion” became, the less relevant to the underlying thread I felt it became. Does this make sense to others here?

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#640

While variance is substantial, meta-analysis as well as larger individual studies (including this one) have reported that simvastatin modestly but significantly reduces testosterone on average

Lipid change on statins was previously found to significantly predict testosterone-change in men, particularly on simvastatin

The study referred by your source shows an issue with a particular kind of statin (simvastatin) but even here the decrease was very modest.

Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial - PMC (nih.gov)

#641

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#642

What is the “really hard work” bucket?

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#643

I don’t think anti-aging is that at all. I think it is a common misconception.
For you maybe, but not if you generalize.

About 20-30% reading that will decrease their longevity I would guess.
A person on the carnivore diet eating high saturated fat, for example, with astronomical apoB, would continue to have such apoB with that advice. They would get atherosclerosis relatively quickly.

Meanwhile, the ‘magic pill’ is applicable to everyone, especially in poly pill form. The same carnivore dieter would decrease their apoB with the polypill, making them immune to atherosclerosis. They would have ITP approved drugs for a potential longevity benefit.

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#644

Hiring and managing a team of 30+ medical professionals… :wink:

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