I have posted elsewhere on this site how I “arrested” my IBS that I had going on for a decade 1983-1993. I had started CR and coincidentally I started taking in epic amounts of fiber. That stopped any and all IBS symptoms and episodes. There was also a kind of natural experiment, wherein I would travel for vacation and off my regular diet, and after about 3 weeks the IBS would come back. I quit CR after some 8 years, but kept up my epic fiber intake. Same story, the IBS was gone unless I was off the diet for a few weeks. That’s how I know it wasn’t the CR that was responsible for stopping the IBS. It’s the fiber. But again, I take in epic amounts, which is why I can’t reproduce it just through diet away from home when traveling - I take a ton of supplemental fiber as well (oat bran, wheat bran, wheat germ, psyllium powder, brewer’s yeast, flaxmeal, FOS, inulin, cranberry powder, blueberry powder etc). I can’t take all those with me when traveling, so that’s when I only get fiber from diet (I’m mostly plant based).
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WJ_PhD
#42
I don’t believe I saw this recent paper in this thread from Nov 20th on tributyrin supplementation in Parkinson’s patients. They used labeled tributyrin to do PET scans in 10 of the patients and confirmed brain uptake to specific regions. For the rest of the study at 500mg 3x/day, they saw decreased systemic inflammation and improvements in motor and cognitive scores. Pretty promising IMHO.
https://www.neurotherapeuticsjournal.org/article/S1878-7479(25)00269-7/fulltext
edited for typo
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Bravo! Wonderful. I had read about beta hydroxy buturate years ago and it was very inexpensive. Now I will have to consider which form to add. Thank you so much!
I think I missed that narrative… but I’m grateful you summarized and restated it for me here.
I’m so pleased that you too have found a solution to your IBS.
CR triggers a stress response (which of course has some benefits). SCFA’ s signal our brain that “everything is good, fuel is here and steady, you can focus on repair and maintenance, the world is quiet and predictable”.
That SCFA’s “kill ketosis”, is unfortunate, because some in that tribe see soluble fibre as “an enemy”.
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Cut plants out of your diet and focus on protein and animal fats. Inflammation will plummet
