#1

Hello wonderful community

I am taking a supplement called Calcium d Glucarate.
How does it work?
Glucuronidation is the liver’s normal process of attaching a glucuronic acid molecule to potentially harmful substances to detoxify and eliminate them from the body.* During phase II liver detoxification, certain hormones and various fat-soluble toxins will undergo glucuronidation and be excreted through the bile or urine. Calcium D-Glucarate helps this elimination process to occur uninterrupted.* In short, it Calcium D-Glucarate’s detoxifying and chemopreventive properties are attributable to its ability to increase glucuronidation, and the accompanying excretion of harmful compounds.* It does so by inhibiting the enzyme beta-glucuronidase.*

Do any of you have an idea if it can interact with Rapamycin and cause it to eliminate faster?

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#2

I asked the Perplexity LLM interface, “Does “Calcium D-Glucarate” interact with Rapamycin?”

Based on the information provided in the search results, there is no direct evidence that calcium D-glucarate interacts with the drug rapamycin (sirolimus).The key points from the search results are:

  1. Search result 5 is a study that specifically investigated the effects of rapamycin (sirolimus), along with cyclosporine and tacrolimus, on renal calcium and magnesium metabolism in animals.
  2. The study found that while cyclosporine and tacrolimus increased urinary calcium and magnesium excretion, rapamycin did not affect calcium excretion but did increase magnesium excretion.5
  3. Importantly, the study stated that “Rapamycin did not affect gene expression in any of studied proteins” related to calcium and vitamin D metabolism in the kidney.5
  4. None of the other search results 1234 mention any interaction between calcium D-glucarate and rapamycin.

Therefore, based on the available evidence, particularly the animal study 5 that directly examined rapamycin’s effects, there does not appear to be an interaction or cross-talk between calcium D-glucarate and the drug rapamycin in terms of calcium/mineral metabolism or detoxification pathways.The lack of any reported interaction aligns with their different mechanisms of action - calcium D-glucarate aids in glucuronidation and excretion of toxins/hormones, while rapamycin is an mTOR inhibitor used as an immunosuppressant after transplantation.So in summary, the cumulative search results do not indicate any known interaction between the supplement calcium D-glucarate and the pharmaceutical drug rapamycin. However, more research may be needed to definitively rule out any potential interactions.

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