#1

I just started taking rapamycin (6 mg once a week on Fridays), but also take the following:

Acarbose (100 mg, 4 to 6 days a week, depending on carb intake)
Sertraline (100 mg daily)
Omega-3 (EPA + DHA)
Marine Collagen
Glycine
Astaxanthin (AX3 Bio-Pure Astaxanthin, 12 mg)
Vitamin D3 + K2
Magnesium Citrate
Magnesium L-Threonate
Methyl B12 + Methyl Folate
Lutein (10 mg) + Zeaxanthin (2 mg)

I became especially concerned about astaxanthin, lutein, and zeaxanthin because these are antioxidants and I read that they can lower rapamycin’s effectiveness. Someone here mentioned that it’s best to skip astaxanthin on the days you take rapamycin as well as the following day, and I have been doing that, but astaxanthin can apparently stay in your body for a long time, so would it be best to not take it at all while you take rapamycin? I’m concerned about lutein and zeaxanthin for the same reason.
Also, if any of the other supplements or medications I’m taking lower rapamycin’s effectiveness, please let me know!

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#2

Sounds like a good question to pose to a deep research AI.

#3

I’d be more worried about collagen and glycine as they (and other amino acids) raise mtor, possibly acting counter to rapa. Some people on here avoid amino acids for a few days after rapa dosing, while others don’t seem to skip them. I’m not sure we have any on what if these things lower rapa’s mtor effectiveness or if it’s just people thinking about the mechanisms.

A quick google search suggests that astaxanthin doesn’t have a large effect on mtor and may lower it in some cases.

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