Just curious on how many of those anecdotes were possibly due to underdosed/bunk Reta.
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I’m doing both. Rapamycin should only really be an issue for a few days so I time it with rest days.
It is anecdotal but widespread. At the moment with incomplete human trials these user experiences hold more weight.
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Davin8r
#1704
If it were underdosed/bunk, those same users wouldn’t have experienced superior weight loss despite less appetite suppression compared to tirzepatide/semaglutide. Reta has quite low affinity for the GLP-1 receptor compared to tirz/sema, so it shouldn’t be surprising that for most, it’s not as appetite suppressive. Many users seem to like the fact that compared to when they were on tirz, they can now enjoy food again but still find it easier to not overeat.
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How do you time it exactly? Can you write out your schedule and dosing?
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Monday - Legs
Tuesday - Upper body
Wednesday - Rest day - Rapamycin dosing
Thursday - Rest day - Tirzepatide dosing
Friday - Legs
Saturday - Upper body
Sunday - Rest
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Can you share your dose and your objective for your training? Also the time of day of the workouts and the rapamycin dose?
I’ve run experiments with my training at different doses and have reached a different conclusion about the compatibility of rapamycin with hypertrophy training… but I suspect it’s because we have different objectives.
Edit: this is really the wrong thread for this conversation. We should probably move elsewhere.
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adssx
#1708
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I believe we’ll see generic empagliflozin this year, at least in my country.
Brand name is about US$1/day, so it’s not that bad anyways.
I take canagliflozin personally.
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LukeMV
#1710
Hopefully you share the results here. I use 10mg and wonder what would happen if I used 25mg. Do you plan to also get a urinalysis? (I pee +2 glucose all the time on 10mg). I would also wonder how it impacts your electrolyte panel and uric acid (if you test this), or anything else you notice that looks different compared to previous lab results.
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LukeMV
#1711
Yea I have read people say Reta doesn’t suppress their appetite much but that just makes me think they aren’t using a high enough dose where it would happen. I also think many used to use Tirzepatide, which seems to suppress appetite more so they are making the comparison. The paradox here is that Reta has shown greater weight loss than Tirz in the studies.
My own anecdote is that I got reduced appetite on 3mg so I cut back down to 2mg (divided MWF shots). This seems to be my sweet spot where I am still hungry but get full faster.
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FYI, generic empagliflozin is available at the Indian pharmacies.
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Yes it is, take it at your own risk. When I first bought empagliflozin from India, I did my usual procedure of putting in the same order to three different vendors, so that I increase the chance at least one will get through and if I lose one I have not lost too many meds. Anyhow, with one vendor (whom I no longer use), I forgot to specify the original manufacturer brand, and what I got from him was a generic. Well. The tablets looked discolored with random green yellowish patches, and I decided to discard them. I can’t claim they were “bad”, but between their dodgy appearane and the harrowing tales of quality control at Indian pharma manufacturers, I decided it was too much for my risk tolerance. It was my fault for not specifying, but I never made that mistake again. Now with the orders still coming in (hopefully before 08/29/25!), I will have completed my 5 year stash of brand name 25mg Jardiance - yes, Jardiance a few thousand dollars, but Health, well, is priceless. YMMV.
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Agetron
#1714
Brand name 25 mg Jardiance.
I just received my Jardiance prescription through insurance - 25 mg – 30 pills cost $50. I am doing a 7 day loading… then will go every other day. At that rate… $300 a year. Not bad, and I am getting it directly from my pharmacy.
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Brilliant. That’s actually cheaper than I get from India - I get them at $1 per tablet. I don’t care - I want the brand name whenever can.
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Every time I try even a half dose of dapagliflozin I get what feels like a mild urinary tract infection, but I test negative and it’s gone within 5 days after stopping. I stay well hydrated. Has anyone else had and been able to solve this problem? I can’t take the drug anymore.
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Beth
#1717
Are you taking methylene blue? If so, that is supposed to help with that issue.
I’m taking MB and dapagliflozin.
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Hmm, I was at one point but I don’t know if I was the last time it happened. Good tip!
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Do you take MB daily and do you cycle?
Dose?
tks
Agetron
#1720
Interesting… I started Jardiance this week and was using MB every 3rd day… so far all good.
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If you have commercial insurance, you can get Jardiance for $10/mo with the manufacturer’s co-pay coupon.
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