I recently posted about statins and the liver. Here is something about other cholesterol lowering medications and liver cancer.
Use of cholesterol-lowering medications in relation to risk of primary liver cancer in the Clinical Practice Research Datalink
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.35436
“Table 2 details the associations between the use of cholesterol-lowering medications and liver cancer overall. In the adjusted analysis, ever use of cholesterol absorption inhibitors was associated with a reduced risk of liver cancer (OR, 0.69; 95% CI, 0.50–0.95). When examined according to recency of use, past use of cholesterol absorption inhibitors was associated with reduced risk (OR, 0.52; 95% CI, 0.33–0.83), but current use was not (OR, 0.92; 95% CI, 0.59–1.42). An examination of cumulative dose identified no stronger effects at higher doses. In contrast to cholesterol absorption inhibitors, ever use of bile acid sequestrants was associated with increased risk of liver cancer (OR, 5.31; 95% CI, 3.54–7.97), which was most evident for current use (OR, 13.08; 95% CI, 6.98–24.49) and was most pronounced at the lowest cumulative dose (OR, 12.30; 95% CI, 5.42–27.90). No associations were observed between the use of fibrates, niacin, or omega-3 fatty acids in adjusted analyses, overall, by recency of use, or by dose. As anticipated, ever use (OR, 0.65; 95% CI, 0.58–0.74) and current use (OR, 0.61; 95% CI, 0.54–0.69) of statins were associated with reduced risk of liver cancer.”
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adssx
#2
Is there any other cholesterol absorption inhibitor than ezetimibe?
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Not that I am aware of. Also this is in the UK, so likely only drugs approved/used by the NHS, of which I believe EZ is the only one in that class.
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