#1

FWIW…

This paper is buried in another thread.

Should have a posting on it own.

Will give you good understanding of the mechanisms of taurine.

7 Likes
#2

Thanks for underlining this interesting article, that includes among other things details on the anti-atherosclerotic effects of taurine and black pepper terpenes

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The protective effects of taurine and terpenes in preventing the progression of atherosclerosis. Inflammation, oxidative stress, hypercholesterolemia, hypertension and AngII can all contribute to endothelial dysfunction that is accompanied by the infiltration of LDL into the intima of arteries. LDL is modified by ROS to produce oxLDL. Inflammation promotes the recruitment and differentiation of monocytes into macrophages via the upregulated expression of the adhesion molecules ICAM-1, VCAM-1, and MCP-1. Macrophages absorb oxLDL to promote the formation of foam cells and contribute to plaque accumulation in arteries during atherogenesis. In addition, activation of LOX-1, TLR2, TLR4, RAGE, and AT1R by their specific agonists in SMCs can contribute to the production of ROS and pro-inflammatory cytokines via NF-κB-signaling to further upregulate inflammation, endothelial dysfunction, and macrophage recruitment. Taurine and terpenes modulate atherogenesis by suppressing inflammation through inhibiting NF-κB-induced pro-inflammatory cytokine production signaling pathways, reducing ROS and HMGB1, and promoting hypocholesterolemia and reduced LDL plasma concentration. Additionally, both taurine and terpenes can reduce hypertension by inhibiting L-type Ca2+ channels and preventing subsequent Ca2+ influx to prevent vasoconstrictive responses. Abbreviations: AngII, angiotensin II; AT1R, angiotensin type 1-receptor; CB2R, cannabinoid type 2-receptor; EC, endothelial cell; HHcy, hyperhomocysteinemia; HMGB-1, high-mobility group box-1; HOCl, hypochlorous acid; ICAM-1, intracellular adhesion molecule-1; IL, interleukin; LDL, low-density lipoprotein; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; MCP-1, monocyte chemoattractant protein-1; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; NOX, nicotinamide adenine dinucleotide phosphate oxidase; oxLDL, oxidized low-density lipoprotein; ROS, reactive oxygen species; RAGE, receptor for advanced glycation end-products; SMC, smooth muscle cell; TLR, toll-like receptor; TNF-α , tumor necrosis factor alpha; VCAM-1, vascular cell adhesion molecule-1. Figure designed with Biorender.com.

5 Likes
#3

This is a fascinating review @Joseph. Thank you. Now we need more clinical research on it.

1 Like
#4

There is no money in non-IP compound’s.

FWIW, if you are taking taurine you should be taken black pepper/piperine and grape seed extract{review the post]with the taurine.

Edited on 10/07/2024 at 12:07pm EST

from the paper;

…“Based on previous dosages used in the literature and clinical studies, we propose a theoretical dose of 500 mg –3 g of taurine [115,173,176,177,223] and 5 –150 mg of black pepper extract [69,105,162] to be taken orally in capsule form, twice a day. Further clinical studies are required to confirm this hypothesis that a combined taurine and black pepper supplementation may be a viable adjunct treatment of CVD and its complications in humans.”…

1 Like
#5

So true unfortunately. Yet I find at least a little room for optimism via the small levels of NIH funds thrown in this general area. And look at how we know what we know about more than a handful of non-IP compounds, such as taurine. I would think that a dedicated group might be able to demonstrate the merit of increasing funding. Just reflecting on my own experiences, several non-IP supplements have improved one or more of my health metrics with a high degree of confidence.

2 Likes
#6

Yes, very interesting but there is a conflict of interest regarding the product that was used for the paper.

“The author A.Z. is in current discussions with the manufacturer of PhytoCann BP®; however, the insights presented in this paper were arrived at independently and the views expressed are those of the authors. The other authors declare no conflict of interest.”

#7

What does non-IP mean?

#8

Intellectual Property - patentable stuff.