Creatine upregulates the mRNA content of genes and protein content of kinases in muscle - independent of exercise intervention.”
“ In this study, 12 healthy men were supplemented with either a placebo or creatine (loading phase, 20 g/day × 3 days; maintenance phase, 5 g/day × 7 days) for 10 days.”
“ Creatine supplementation significantly increased fat-free mass, total body water, and body weight of the participants (P < 0.05).”
“ These are involved in osmosensing and signal transduction, cytoskeleton remodeling, protein and glycogen synthesis regulation, satellite cell proliferation and differentiation, DNA replication and repair, RNA transcription control, and cell survival.”
“ Overall, creatine induces rapid and coordinated induction of these regulatory proteins at the molecular level, resulting in increases in maximal muscle strength and power, and fat-free mass, independent of training and/or dietary intervention.”
This comes from research:
Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation
https://journals.physiology.org/doi/full/10.1152/physiolgenomics.00157.2007
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It works as a form of ATP battery.
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adssx
#3
Has anyone reproduced the findings since 2008?
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