https://www.embopress.org/doi/full/10.15252/emmm.202318526
#incrediblepapers . the paper above is SO relevant on multiple fronts
Do people who eat a lot of fried food naturally accumulate more of this?
results correlated with isoDGR protein levels detected in body tissues by WB, with significantly higher levels of isoDGR damage being observed in liver from 17‐month‐old mice compared to 3‐month‐old mice. Accordingly, mAb treatment reduced levels of isoDGR‐damaged proteins in liver tissue from 17‐month‐old mice, whereas IgG1 isotype control or PBS injection were unable to replicate these effects (Appendix Fig S9A). Together, these data clearly indicate that mAb treatment reduces isoDGR levels in body tissues, which is further associated with a marked decrease in systemic inflammatory cytokines.
2 Likes
EnrQay
#2
It’s a good start to this type of research. Criticism: only 5 mice per group, mice genetically could not clear the damaged protein, and the mice were young. I’d like to see an experiment ($$$) with more old normal mice.
How important is this specific protein residue in human disease? Are other damaged proteins sequences as important?
Thanks for posting. This is a very important finding. This may just be a method to partially fix a small subset of the various stochastic damages in the body, of the kind that epigenetic reprogramming would not fix.
I consider this study important enough that I wrote briefly about it on my substack page:
