#31
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#32

Think!

“Can I use Cyclodextrin to improve the solubility of a compound?”

https://www.researchgate.net/post/Can_I_use_Cyclodextrin_to_improve_the_solubility_of_a_compound

#33

The more I look into this, the more I am interested in an IV solution.

“Cyclodextrin-based delivery systems in parenteral formulations: A critical update review”

https://www.sciencedirect.com/science/article/pii/S093964112200145X

Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

https://www.sciencedirect.com/science/article/pii/S0144861723009657

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#34

I want to share my experience with Cavadex, which was recommended to me by Dr. Roberts from Ohio (who I was referred to by my longevity doc in Floriday.) In May, 2023 I experienced some tightness in my chest, and Dr. Roberts gave me a protocol that included Cholrem Cavadex, which was his best suggestion.

At that time, I had a CAC score done, total score was 223 (84%) comprised of Left Main = 0, LAD=141, CRX/LCX=10 RCA=72.3 with the comment that there was a suspected high grade obstruction in the proximal to mid segment of the circumflex.

So at Dr. Roberts suggested I started Cavadex among a few other things which included K-2. He suggested also phospholipids, but I still have that in my fridge. So starting in May 2023, I did 90 doses of Cavadex 8 grams over a period of about 4.5 months. Then in January 2024 I started a course of the 16 gram product and finished 45 doses before getting a new CAC store in May 2024.

My May 2024 results are as follows:
Total score was 212.2 (a decrease of a bit under 5%, however the new score seems to include PDA with RCA which the original did not, so I’m not sure I am comparing apples to apples–it seems that the decrease in total score may be higher than the numbers suggest because the new report includes PDA, where the original did not. Values in May 2024 are Left Main=0, LAD=113, CRX/LCX=7.8, RCA+PDA=91.4.

So, overall, it seems to have reduced my overall calcium score, but how meaningful is this considering the cost of the product and discomfort involved? (Not THAT bad, but it seems like it would take many years to reduce my calcium score by a meaningful amount.

So, there is my n=1 attempt to reduce calcium. I still have about 45 doses of the 16g, so I’ll probably finish it but my hopes are somewhat dashed. Incidentally, I also take a Vitamin C by Natures’ Essentials which combines the Vitamin C with cyclodextrin and then encapsolates that in a liposome, which you may know helps it to pass through the digestive tract. For those of you who are taking Cyclodextrin orally, you are wasting your time, as it is destroyed in the digestion process. FWIW, there are instructions out there and on YouTube that show you how to make a liposomal product in your kitchen with grain alcohol, lecithin and an ultrasonic cleaner device. (I’ve done this, very easy…probably can make a good Cyclodextrin phospholipid for oral use which could be helpful over time. But for cyclodextrin, the best way to take it is IV (which is how Dr. Roberts took it), and good luck with that. Anyway, hope this helps.

4 Likes
#35

That seems within the margin of error.

Are you treating apoB and have you measured Lp(a)?

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#36

I use it and don’t expect it to reduce the calcium score at all. It should certainly slow the rise of the calcium score. It should reduce inflammation.

If you want to reduce the calcium score, then DMSA is the best way I have found. I’m not sure you need to or should. I’m not a doctor.

Chelation therapy for heart disease

#37

Another false statement from you.

It is not possible to reduce or reverse heart calcification, measured on CAC.
https://x.com/MohammedAlo/status/1737484542053662972

#38

Two things. 1. I had done previous CAC scores and it has been steadily rising for about 5ish years. I believe had I done nothing, it would have increased. And as noted, the second score includes another measurement not included in previous ones, and the total still decreased. It’s something, and with that, it seems to be beyond the margin of error 2. After the score in 2023, I started rosuvastatin and zetia. Lp(a) is high, around 223. I am going to see if my Lipidologist can help me get my insurance to cover PCSK9s next week. If not, I will either pay out of pocket or wait for CETP inhibitors to be approved in a few years.

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#39

It is within the margin of error, it is 10 points from a 220 point score.

If you started at the same time rosuvastatin and zetia that is an obvious confounder in making your CAC score not progress further. The important thing with all of these therapies is that they are proven to reduce your risk of events and stabilize plaque. I would try to reduce Lp(a), too, like you’re doing, that’s high. Good work either way so far.

#40

Is there a way to PM you? I’d like your opinion on something. This isn’t the topic for it, and I don’t see how to PM you or tag you in a new thread.

#41

You can tag me like this @AnUser in a new thread.
Either way, I have enabled PM’s so now it should be possible.

#42

Well one thing to consider is that although your calcium score did not go down significantly, that doesn’t mean that your soft plaque (which really is the issue) wasn’t significantly reduced. The only way to know that is with a CLEERLY test (CT angiogram with AI analysis, https://cleerlyhealth.com).

2 Likes
#43

Definitely true. I’ve considered that possibility but I was going for the whole enchilada when I opted for cyclodextrin.

#44

You can also measure soft plaque using CIMT and magnetic resonance angiogram (MRA), also known as magnetic resonance angiography.

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#45

hallelujah!..he (@AnUser ) has seen the light! Back to being an “Average person”.
The lost lamb has rejoined the fold and is again accessible, open, non-judgemental and ready to commune with the masses.
Another pilgrim on the “Road to Wellville”.
“Just a stranger on the bus tryin’ to make his way home”

2 Likes
#46

Just an average Joe.

Grillin’

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#47

With Cyclodextrin I’ve seen it should be taken either IV or as a suppository. I’m wondering if anyone knows whether orally in enteric coated capsules would work? (It would be a much nicer way to take it!)

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#48

Has there been any further evidence that this stuff actually does anything other than the original claims by the Cavadex people?

#49

FWIW

Cyclodextrin by IV, not new…1992

It is not profitable.

#50

I’ve got nothing. Used a big bunch of it this year and feel about the same, no way to know whether it has any effect at all. Very expensive and risky to do the cleerly, all I have is a yearly CAC. It’s coming up Feb 13. Can’t wait, but doubt the cyclodextrins will make much difference.

1 Like