#1

Well the only two things my research uncovered that had ANY scientific backing whatsoever (although certainly not placebo controlled double blind studies) were trodusquemine and this:

Happy to hear any opinions on Cavadex.

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Is Trodusquemine (for Atherosclerosis), the next Rapamycin?!
Reversing Atherosclerosis and Cancer
"Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity"
CAC of 323. What can my 77 yo father do about this?
Is Trodusquemine (for Atherosclerosis), the next Rapamycin?!
#2

Both Cavadex and Cyclarity are leveraging the science around Cyclodextrins for atherosclerosis.

I have not delved deeply into researching these, but I would if I had been diagnosed with high levels of plaque formation in my arteries. What is unclear to me are the issues with just using Cyclodextrins, and what exactly Cyclarity is doing that would improve the molecule (that it sounds like Cavadex is not doing).

Obviously if there were no issues with using Cyclodextrins as they are today for reversing heart disease, we’d be using them already since they seem to be well recognized as having potential in this area.

Some starter resources / videos on this issue:

This is a 5 year old video, but a start:

Cyclodextrins uses for Longevity & Heart Heath with Matthew O’Connor, Founder Cyclarity, Inc.

Recent Papers:

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#3

FWIW

Purchased on eBay 600g for $52.00

Shipped from Japan

Forum Member “Bicep” is the person who pointed this out. He has been using this.

Cost is much less than “CAVADEX” capsules which is overpriced α-Cyclodextrin.

Review the thread below;

Consider;

Nattokinase
Lumbrokinase
Serrapeptase

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#4

It sounds like Cavadex first came out in 2019. Given its been on the market for a while, I would expect more customers talking about it. But I check on Twitter and there are no recent mentions (actually, none at all). I find this a little strange. More information on the research they have done: https://www.cholrem.com.au

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#5

Thank you all, will dive into these videos!

#6

That makes me believe people who have a financial interest or relationship with the company is astroturfing it here while at the same time questioning other, proven treatments to make the former more effective.

There are a lot of users here with links to their companies, websites or podcasts in their bio to increase their SEO rating as well and some of them clearly try and post regularly just to make money.

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#7

I’ve known Pestodude for the past 3 years with his participation in discussions on Twitter and here. I have no concerns about him astroturfing the site. Lets not jump to conclusions.

Skepticism is good, but cynicism is not helpful. Lets just evaluate it from a science perspective and see what the pros and cons are. The area of cyclodextrins is obviously one of significant scientific merit. But what are the pros and cons of this approach as they stand today, that is the issue


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#8

I didn’t say any names but I didn’t mean Pestodude. I have debated about this Cyclodextrin before on the site and it looked shady to me then. I guess pestodude learned about this from those discussions.

If no one knows about a compound, no one discusses it, nor mentions it on reddit or other sites then it is suspicious it is talked about here. The likelihood anyone knew about it organically is low as how would they learn about it?

#9

Studies have been posted before both pro and con. I found this study of particular interest:

For 200 participants taking α-cyclodextrin compared with 201 participants taking placebo, there was no difference in total cholesterol after 6 months (−1.5 mg/dL; 95% CI, −6.6 to 3.5 mg/dL; P = .51)

Source: Effects of α-Cyclodextrin on Cholesterol Control and Hydrolyzed Ginseng Extract on Glycemic Control in People With Prediabetes A Randomized Clinical Trial

#10

I thought cavadex had to be administered rectally?

#11

Yes - but interestingly in the negative study referenced above, it was an oral delivery:

Participants attended monthly visits during the 6-month intervention and were asked to take 12 pills daily (2 capsules before and 2 tablets after breakfast, lunch, and dinner). Each capsule contained either 160 mg of HGE or placebo (maltodextrin), and each tablet contained either 1000 mg of αCD or placebo (microcrystalline cellulose). The placebo pills were indistinguishable from their active counterparts. Participants were provided a 1-month supply of pills at each visit, and leftover pills were returned at subsequent visits to monitor compliance. Participants met with a study dietitian monthly and received personalized advice for prevention of type 2 diabetes, focusing on a healthy, hypocaloric diet, moderate intensity exercise, and behavior management.19

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#12
#13

Actually - I do find some references on Reddit. And they aren’t good:

https://www.reddit.com/r/Supplements/comments/1853f9p/has_anyone_used_or_looked_into_cavadex_from_what/

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Source: https://www.reddit.com/r/Supplements/comments/1853f9p/has_anyone_used_or_looked_into_cavadex_from_what/

I’m not sure - but this may be the Facebook group that is mentioned - but this seems like a company-sponsored group (and they may be blocking and deleting postings that are negative to their product, so take it with a grain of salt):

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#14

I found out about it by googling “products that reduce plaque” which led me to this article: https://www.cnbc.com/2017/11/03/drug-melts-away-heart-fat-in-just-one-dose.html

For the record I am a talent manager (personal manager for actors) and have absolutely no financial interest or affiliation with any other product or any other industry for that matter.

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#15

It was long ago I looked into this but it looks like there are some mentions of it. Generally you’d want to see lots of people recommending something and not backed up by a company with almost no mentions. Hearing damage does not sound good.

Cyclodextrin I meant. I believe you either way lol.

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#16

Utter corrosive nonsense.

But since you post such great studies,
:wink: Right, @RapAdmin ?

Name names, @anuser. Surely you have no qualms about naming names.

#17

On this Len, I agree with you. I’ve seen no excess commercialization of anyone posts here. A few companies / groups have tried to post spam but it quickly gets identified or blocked before its posted.

I’m fine with people who are regular members here having links to their websites in their personal profiles, and fine with people posting occasional links to relevant activities.

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#18

I don’t believe that counts as an insult, does it? @AnUser may be somewhat paranoid regarding that, but aggressive marketing and product shilling has been a thing since forever on popular forums such as reddit.

#19

jfc

Handwaving misdirection.

#20

Getting off topic guys
 please back to cyclodextrins :wink:

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