Dasatinib & Quercitin accelerates aging as measured by DNA methylation Clocks

[cronoslogical]

For those using D&Q, what do you think about the conclusions of this study? I saw very few responses to this. After reading this, I am uncertain about continuing D&Q.

Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

I’m still digesting this but the unexpected results seem significant. aging-v16i4-205581.pdf (1.6 MB)

[hunter_pomodoro]

I don’t use D+Q but senolytics are supposed to ablate senescent cells, not decelerate DNA methylation, so this isn’t all that surprising. Also changes weren’t noticed in the GrimAge and DunedinPACE one way or the other, so this could just be chalked up to the first generation clocks being more noise than signal.