#1

I recently found a site called Microbiome Prescription. It was created by a scientist who got CFS as a science based way to . I shared this with some of my integrative health practitoners and they were curious and interested, not many people are aware this exists so I’m sharing it here.

Basically you upload your results from one of the approved sequencing providers, and it will give you an output about what kinds of foods, substances, probiotics, etc to decrease/increase. You can even start looking at bacteria now if you suspect you have something, for example Desulfovibrio which is common in autism and Parkinson’s.

He keeps a blog as well where readers write in and he goes over the results with them. I tend to agree with some of his philosophy around probiotics, that most of them are junk. It seems like most people have the best results with a probiotic E Coli (Mutaflor/Symbioflor 2) or Clostridium Butyrate, which are NOT common probiotics. I agree also on his take cautioning against Lactobacillus, as a lot of those produce D-Lactate or are histamine producers, which is what you don’t want in sensitive people.

I wanted to go this route but I screwed up big time by ordering from NirvanaBIome - stay away from them, they do NOT give the full data that they advertise of 6000+ bacteria plus fungi, viruses, etc.

Anyone done anything like this or interested to do so?

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#2

Interesting and very current stuff on the Microbiome Prescription website blog. I’ll have to dive into it when I get back from traveling.

#3

So it recommends what to eat and take that would decrease or increase certain microflora? Basically what’s published in the literature?

I think Michael Lustgarten has been doing some of this, and afaik it hasn’t worked even if the studies say some food or drug will work. At the same time, you don’t know if you don’t test. So most of the heavy lifting is in repeated testing.

#4

I’m about to run a six months N of 1 on myself of a postbiotic product and I have to say this sounds like it would be useful. I’ll do a deeper dive.

#5

Interview with Dr. Sean Spencer, MD Ph.D, Gastroenterologist and Physician Scientist at Stanford University.

5:31

  • **Over the counter probiotic supplement use was linked to a 70% lower chanCe of response to immunotherapy (anti PD 1 checkpoint inhibitors in melanoma patients)

  • **42% of all patients report taking over the counter probiotics

  • **Probiotics were linked to lower gut microbiome diversity, previously shown to be associated with poorer response

  • **Patients eating high fiber diets were about 5 times as likely to respond to immunotherapy treatment.

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#6

I think the author of this blog generally is against over the counter brand probiotics. I understand why he’s saying “over the counter probiotics” in that way as it’s usually something like Lactobacillus that you get at the grocery store. My take on this blog/site is that they haven’t found those types of probiotics useful with the exception of some high quality Bifido strains.

One of the probiotics he does recommend has been used in trials to help the immune system after transplants: Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation | Bone Marrow Transplantation

#7

Good luck, what postbiotic are you using? My doctor told me about ThaenaBiotic (https://thaena.com/) which sounded quite interesting. It sounds a bit like you get the benefits of a fecal transplant, it’s the only postbiotic I’ve heard of that uses human material in that way.

I’m open to trying it but healing from gastritis currently and since it has some citric acid in it worried about that.

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#8

Yes, those are the ones I’m using. I’ve been following the company since they launched their initial product. They finally launched direct to consumer. While they’re not an aging company they did some studies in worms and the worms lived longer using Thaena. I’m pretty interested in anything that can import a healthier younger state. The beauty of this is that it’s transitory.
My hunch, is that replacing a healthy gut microbiome from younger, healthy donors should replicate FMT, which I would like to have, but this is the closest proxy. I’m going to do Viome testing, blood, and see if there’s any effect on inflammation and immune markers. Figured it’s worth trying to six months.

#9

Yes, basically that’s it, I believe it’s a mix of what’s in the literature and perhaps some other tweaks. He also does some interesting things in his blog where users share the results and I believe it can assign likely health conditions to the bacteria found which seems to be fairly accurate.

I feel like what I see consistently in his blog is that he generally recommends E Coli probiotics or the C butyricum as these seem to help the most conditions in general.

#10

Wow, make sure to update us when you are done! I also was very curious about this one and my doctor seemed to have positive experiences with her patients.

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#11

Yes, I’ll make sure to do a report when I’m done.

#12

I’ve reported on my experience elsewhere across the forum. Most extensive account of my experience at Gut check - best approach.

I worked with Anthony Azar, MD on this. The protocol included: metronidazole rifaximine and augmentin.

I believe the protocol described in the link came as close as possible to FMT.