#1

Hello everyone,

I am Mateus from Poland, I am 36 years old, and I have been following your forum for a year.I’m taking rapa for few moths. I have a wife with type 1 diabetes, and I suspect she has started developing neuropathy. She has problems with blood pressure, for example, 93/60, and a pulse above 100 while sitting. Does anyone have knowledge of what can help with nerve regeneration?

I was thinking about Dihexa, as most AI also suggest it to me. I took it myself about a year ago, during another attempt to cure my lack of concentration and memory problems. It turned out that I had ADHD my whole life :confused:

My main motive regarding dihexa is the research on the drug ATH-1017 and ATH-1020, which have very similar effects to dihexa.

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#2

I don’t have any suggestion for nerve problems but getting her diabetes and health markers under control as best as possible is a great first step.

“Tirzepatide significantly reduced HbA1c and body weight in adults with T1D. A randomized controlled trial is needed to establish efficacy and safety of this drug in T1D.”

Additionally as an anti-glycation strategy I every day I personally supplement both L-carnosine and benfotiamine.

Regular exercise will also be useful.

The blood pressure is odd.

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#3

My wife is on ozempic since year

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#4

Was she overweight before?

I’m trying to understand why her blood pressure is so low. It might be autonomic neuropathy.

I hope someone with more understanding can give some better suggestions here. All I can suggest is as best as possible get blood sugar under control.

What is her HbA1C like? Has she tested HOMA-IR?

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#5

My mom had type 1 for nealy 50 years and suffered some from neuropathy. I think alpha lipoic acid is a no brainer. This is a good article:

Maybe drugs are better, but I start with the low risk stuff.

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#6

Correct. She is 30 years old and after pregnancy her weight increased to 83 kg and stayed that way until last year, when her doctor prescribed Ozempic. Now she weighs 60 kg.

#7

I’m more of a fan of tirzepatide (Mounjaro/Zepbound) than semaglutide (Ozempic).

Tirzepatide can reduce HbA1C more effectively than semaglutide.

Do you know what her HbA1C is now, and what it was before weight loss?

#8

Current HbA1c is 7.8, before was something around this. There weren’t huge difference between of them.

#9

IMO getting this to somewhere between 4.5 and 5.0 is a good place to start. I’m shocked Ozempic didn’t make a dent in it. How many mgs of Ozempic a week?

Speak to your doctor about swapping to Tirzepatide. It has better control of HbA1c. Titrate dose up every 4 weeks as per guidelines until you get control of it.

Berberine or dihydroberberine supplementation 1-3x a day can also be useful.

#10

What do You think about rapamycin for neuropathy? Is there someone who tried it?

#11

Maybe it helps, maybe it doesn’t. I still recommend your wife fully focus on getting HbA1c under control to stop more damage being done.

Some studies show it can benefit, some show no effect. Most importantly rapamycin can make blood sugar worse so I would not throw that into her regimen right now given her health status.

At 7.8% HbA1c, nerve damage is very likely still progressing. If you can get it to 5.3% or less for a sustained period, that’s when you might see some reversal especially if you also support regeneration pathways.

If I were in your wifes position I’d be concerned that my doctor isn’t taking more action.

I would increase Ozempic dosage, or swap to Tirzepatide (brand name Mounjaro) and begin titrating up the dose ever 4 weeks.

I’d also be taking berberine or dihydroberberine morning, afternoon and night.

I’d even consider metformin.

I would even consider acarbose with any starchy meals.

There are also SGLT2 inhibitors to consider.

I’d also take supplements like benfotiamine, carnosine, ALA and probably a lot more.

I’d begin exercising regularly.

I would also be retesting HbA1C, HOMA-IR and more every 4 weeks before a dose increase.

The take home message is to remove the cause so her body can begin to return to homeostasis.

Good luck mate!

#12

Many people here are suggesting that you be more aggressive with the GLP-1 agonists.But Type 1 diabetes is an autoimmune disease and will not be fixed with aggressive weight control. Your wife’s HBA1c is too high, but the only way to really fix that is with aggressive glucose monitoring. She should wear a continuous glucose monitor and be on an insulin pump to maintain strict control of her sugars. When you get better glucose control, the neuropathy will slow. Additionally, muscle helps to regulate insulin and glucose and your wife should be on a strict exercise regimen with both aerobic and resistance training. BP of 93/60 is not abnormally low for a sitting woman, but the pulse above 100 is and suggests some autonomic abnormalities. You need to see a dedicated medical specialist and really drill down on these problems. Rapamycin should be way down on the list for now as it also causes glucose spikes.

#13

If I might suggest getting her to a functional medicine Doctor who could be looking at her whole body to see some underlying issues that might be causing some of these problems. Also, I would strongly recommend meeting with a bio medical dentist and get a 3-D comb beam scan done. Dentistry is typically overlooked in a lot of areas of healthcare problems. I personally had no idea that I have been suffering from autoimmune issues because I had three infected sites where my wisdom teeth were removed for the past 45 years. It has taken it’s toll on my body. I finally got the infections, cleaned out through the biomedical dentist and proceeded to have my husband evaluated who is suffering from several declining health issues and found out he also had the same problem of infected sites where wisdom teeth removed in his youth. We are starting to see a turn around after getting these infection infections cleaned up (FYI - I would ask or request that they test the bacteria where the infection was so then you can get on the right medication’s to fix the problem if you have to do this procedure it was really worth it especially for my husband. He’s got some unusual bacteria that he’ll have to go on IV antibiotics).

The body can heal itself, but when things are inhibiting it from doing that the body will start to break down so we have to get our bodies in a healing state to stay healthy and live a long life. I know it’s nothing like you’ll hear on this site but personally, I have been through many journeys with my health and illnesses and trying to find a way to get well and this has been the best path so far out of all the things I have tried.

#14

An insulin pump. There is at least one that runs loop now.

For Type 1 neuropathy is prevented by controlling blood sugar and treated by high quality eating (reverse of type 2).

#15

Guys, just a heads up that 4.5-5 A1c comes with huge risks of hypoglycemia for somebody on insulin. She needs to get her A1c under 7.

#16

No, SGLT2 inhibitors should not be used with Type 1 Diabetes and they are not approved for this as they can cause diabetic ketoacidosis in T1D.

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#17

ARA 290, also known as Cibinetide, is a peptide derived from erythropoietin that targets the innate repair receptor (IRR) and is being investigated for its potential therapeutic effects in various conditions, including neuropathic pain. It has shown promise in preclinical and clinical studies for its analgesic and tissue-protective properties ARA 290 is believed to exert its effects by interacting with the IRR, a receptor involved in tissue protection and repair. It has been shown to reduce inflammation and potentially target the TRPV1 channel which plays a role in pain sensation

#18

Steve what Do You think about dihexa?

#19

If you are asking about Dihexa and Peripheral Neuropathy I don’t think it would be beneficial. It seems to have more brain activity than spinal cord activity. There are some studies on spinal cord injury benefit so it may be beneficial, the main issue is that there are no human studies.

My limited understanding of PN is that it needs to be addressed in the spinal cord and the nerves where the damage is happening.

I have some and will probably put it on my “Steve tries everything” schedule but I have to try ARA 290 first, when I sort out the dosing and solubility for proper injection.

Overview. Peripheral neuropathy happens when the nerves that are located outside of the brain and spinal cord (peripheral nerves) are damaged. This condition often causes weakness, numbness and pain, usually in the hands and feet. It also can affect other areas and body functions including digestion and urination.

Peripheral neuropathy - Symptoms and causes - Mayo Clinic.