#1

Did my first 20mg dose after a 5 year break, and it seems to increase my libido?

Took my regular vitamins like yesterday but it feels different today 2h post dosing

PS. if your libido is crashed, stop taking magnesium glycinate before sleep. it kills my libido. to the extent that i run a cycle of HCG + clomid to get my levels back up, yet not a singel increase in libido during the entire cycle, as mag was blunting it. Must be due to how it effect glutamate. kills excitation

2 Likes
#2

This might explain it
 Rapamycin Induces an eNOS (Endothelial Nitric Oxide Synthase) Dependent Increase in Brain Collateral Perfusion in Wistar and Spontaneously Hypertensive Rats - PubMed

Its hard to say how it effects blood flow n oxygen as some studies write that its bad to block mtor post brain injury, that it reduce oxygen n so on

1 Like
#3

This would also explain why it helps CFS, as sensitive MRI on cfs patients show lack of blood flow to the brain. i wonder rapamycins effect on lactate then as well, would think that its reduced.

In Wistar rats, rapamycin increased collateral perfusion (43±17%), increased reperfusion cerebral blood flow (16±8%) and significantly reduced infarct volume (35±6 versus 63±8 mm3,

16% more bloodflow to the brain is great. feel more clairty as well on my 20mg dose. avoid caffeine it reduce blood to the brain by 20-30%

Edit: “Rapamycin, an mTORC1 inhibitor, can affect lactate levels in cells and tissues. Studies show that rapamycin can reduce lactate production in certain cancer cells and also impact lactate accumulation during wound healing” .

3 Likes
#4

Did not know magnesium glycinate can lower libido.

What aspects of libido are being improved by this dose of rapamycin?

#5

@AustraliaLongevity sensitivty. i can feel it without touching. wich is something magnesium and people with SSRI/finsteride or what its called, the hair drug that block DHT, all get loss of sensation

Just saw this: Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice | Journal of Ovarian Research | Full Text

In female mice tho but intresting that blocking mtor raised there test


1 Like
#6

Sorry, most anything at your age will increase or decrease libido. It sounds like you are chasing the libido you had when you were 18. Well, unfortunately, as we age, libido decreases. What do you think contributes to the demand for rhinoceros horns and goat gonads?

At your age, pictures alone can significantly influence your libido by either raising or lowering it. There is such a plethora of things that will do this that your N=1 observation that magnesium glycinate lowers your libido is probably just coincidental.

“Magnesium glycinate is a form bound to glycine, which has calming properties and may promote deeper sleep. Improved sleep can indirectly support libido, as poor sleep is associated with lower testosterone.”

Glycine, the amino acid in magnesium glycinate, is an inhibitory neurotransmitter, but there’s no evidence it suppresses libido. In fact, glycine has shown neuroprotective and cognitive-enhancing effects, not sexual suppression.

Maybe you are just misinterpreting the result. Some people may feel relaxed or sedated after taking magnesium glycinate, which might lead to a temporary reduction in arousal or interest, especially if taken right before bed. This is not the same as a suppression of libido but rather a transient state of calm or sleepiness, which could be said of many forms of magnesium.

“There is currently no strong evidence that taking magnesium glycinate before sleep reduces male libido. In fact, some data suggest that magnesium may support healthy testosterone levels and sleep quality, both of which can positively influence libido.”

If you have any studies that contradict this, please post them.

“Our results show that supplementation with magnesium increases free and total testosterone values in sedentary and in athletes. The increases are higher in those who exercise than in sedentary individuals.”

4 Likes
#7

@desertshores Ive been using testosterone on and off for over a decade, im very intuned what effects my libido and what dosent

Magnesium is the nr1 supplement that people complain about having low libido. ive never seen anything like it

Vitamin D can cause this as well. Retatrutide too, wich seems to be due to how it effect addictions, that it noramlizes the glutamate/NMDA just like magnesium/vitamin D wich causes lack of excitation

You should search magnesium + low libido reddit on google

Some studies say magnesium lower DHT, but i doubt that is true, as magnesium is so critical

Most guys get this effect with mag bound to glycine, as glycine is what lowers mood /excitation, and they can use treonate instead. some get it from all the magnesium verisions

Im not saying magnesium tanking your testosterone on a blood test, but mentally. Vitamin D is crucial for testosterone yet tons of guys are getting blunted libido from it (mentally)

2 Likes
#8

I am not interested in anecdotal reports on Reddit.
Your bio has you between 31 and 41 years old. If you are having libido problems at your age and have normal T levels, there is definitely something wrong.

1 Like
#9

I take magnesium glycinate and a lot of glycine powder as well.

I’m also on TRT so it wouldn’t be able to lower my testosterone.

I’d say my libido is moderate. But it depends how you define libido. Is that just getting an erection? Sensitivity? Desire? Pursuit of women? Efficacy of that pursuit? It’s complex.

I wouldn’t say magnesium has reduced any of this that I can tell.

Glycine is known to increase DHT through upregulating 5AR (we can assume DHT is going up if allopregnanolone is also going up)
Pubmed: Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine - PubMed
Full study without paywall Anna’s Archive: C. Venard; N. Boujedaini; P. Belon; A.G. Mensah-Nyagan; C. Patte-Mensah - Anna’s Archive

You could argue that glycine upregulating 5AR is lowering testosterone by increasing conversion to DHT. Although some people feel better sexual function with higher DHT, that doesn’t mean everyone does and that doesn’t mean that lowering testosterone to reach that higher DHT will have favorable results.

2 Likes
#10

ZMA can boost Test levels and libido? The bodybuilding folks use it, but then again, it might not be best to take Mag and Zinc together.

1 Like