#41

Well, I hear you, If you are an active person obviously 1600 calories are not enough. But for most lazy us out there 1600 should be plenty.

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#42

Actually, now that you mention oats, I must admit if you have to have grains, oats are one of best choices. The rest of them are MAINLY bad (will not necessarily kill you lol) but they are not good for humans IMO. And frankly, it is not that they are bad, but they are loaded with calories and carbs and other stuff that provide this feeling of being satiated and comfortable, and boy does every good process in our body stops working when such feeling is experienced and before you know it your body shuts down, and whole hell breaks loose lol.
-Think of it this way, when you eat that juicy steak, your brain gets a message that says this dude made a nice kill and he consumed it, so get everything working nicely so he is in tip top shape for tomorrow to go and make that kill again.

  • On the other hand, you stuff your mouth with 15 donuts, your brain gets a message that is all written in gibberish and has no clue what you did, or what you ate, or how the hell you even got to get such food. Then the brain goes, ok I see the bastard doesn’t need my help. Stop everything, and kill the son of bitch, and before you know it you get cancer, diabetes and cardiovascular disease all in one package lol.
    Anyway, the moral of story, most if not all we have been taught or told about nutrition is totally wrong, and frankly quite harmful (i.e. 60% of calories from whole grains HUGE LOL, eat three meals per day and then snack between meals holly shit whoever came up with this should be hung on town square, you should always make sure you get protein, healthy fats, and carbs each day, holly crap this guy should at least get life in jail without a chance of parole, and then the one that said the most important meal of the day is breakfast should be castrated, his balls should be pickled, he should be hung upside down from the ceiling and fed his pickled balls for the rest of his life hahaa). I’m sure I’ve made my point, if not then you might force me to go into my favorite subject/rant- the so-called “scientists” LOL
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#43

I love the high protein diet and I love meat and eggs and cheese. In this video Dr Been goes through a study that shows how Berberine stops the microbiome from making TMAO after you eat red meat. So when I eat meat, I take an extra 500mg of Berberine and enjoy:

It is also one of the few (maybe only) things that shrink plaque. He goes over that first.

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#44

Interesting, did not know that about berberine. But just a quick note, regarding plaque. Actually high doses of Vit C combined with L-Lysine will not only shrink but also clear 100% of the plaque. It is beyond me that this is not the OFFICIAL treatment for blocked arteries.
I have family history of plaque and about 15 years ago i started feeling pain in my chest when exercising, and that is an obvious sign of plaque. So, I went on a mission to see what would work and did a lot of research, and by chance ran into Dr, Paulding’s protocol which is basically very high doses of Vit C and very high doses Lysine throughout the day for about one year.
I actually did even higher doses than the Paulding dude was suggesting, more like 5 grams of each 3-5 times per day. In about 3 months all the pain disappeared and haven’ t had it ever again. Unreal!
As a maintenance dose I do most days about 2grams of Vit C and Lysine. BTW a side effect of this protocol was that it wards off ALL flu viruses, included Covid. Never got a flu in last 15 years and never got covid either, and of course i did not get jabbed.

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#45

Your maintenance dose is 2 grams, not two mg. You can edit that by clicking the pencil.

High doses of vitamin C over extended periods of time can cause kidney stones. I learned this the hard way. I do 2 grams of each per day too, but just letting people know there can be (non fatal) side effects.

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#46

TMAO doesn’t do anything, so it doesn’t matter that Berberine stops it.

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#47

Does TMAO cause inflammation?

Both observational and experimental studies suggest that TMAO can cause endothelial inflammatory injury.

That is from google.

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#48

TMAO doesn’t cause heart disease, I don’t know about anything else.

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#49

You are right, I meant 2grams of each per day, sometimes I actually do 3 gram of each per day. The kidney stone thing might be the case for some, but never happened to me. But even kidney stones beat open heart surgery lol.

#50

Elevated TMAO could promote CVD via inflammation, oxidative stress, scavenger receptor up-regulation, reverse cholesterol transport (RCT) inhibition, and cardiovascular dysfunction.

association between TMAO plasma levels and increased cardiovascular risk and mortality

Overall, a high TMAO level was associated with both major adverse cardiovascular events (RR = 2.05; 95% CI 1.61–2.61) and all-cause mortality (RR = 3.42; 95% CI 2.27–5.15).

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#51

Mendelian randomization studies show that TMAO doesn’t cause heart disease, another reason why to be skeptical of association studies for complex things. They often fail, in prestigious journals, and perfect quotes that can be cited on forums like this one.

Overall, a high TMAO level was associated with both major adverse cardiovascular events (RR = 2.05; 95% CI 1.61–2.61) and all-cause mortality (RR = 3.42; 95% CI 2.27–5.15).

At first glance many people will believe that is real and the risk is as such. When there is no such thing in reality.

#52

Can you share the study with the conclusion you describe? I’m interested in this topic.

This study used Mendelian randomization to show TMAO is causal for high BP https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354484/

“Our study provides evidence of a causal relationship of TMAO and its precursors with BP, suggesting that mediating the generation of TMAO would be beneficial for lowering BP.”

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#53

Here:

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#54

Thanks. This is interesting. I’ve reviewed a few other studies on TMAO, all of which support the hypothesis that TMAO leads to AGE/cross-linking which causes arterial stiffening which leads to higher BP and CVD. This study used mice to study adding TMAO to see the impact…they found TMAO is causal. I think it’s too early to conclude TMAO isn’t a problem.

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16895

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#55

First off, terrific conversation. I am very much enjoying the lively and constructive discourse on what can (at times) be a decisive topic. I had hesitated throwing the protein level “grenade” in the forum, but am ecstatic with the resulting discussion.

@Joseph_Lavelle : If you are interested in reducing arterial AGE-based cross linking (or any AGE in which serum/blood flow can reach), wouldn’t a supplement of carnosine (or beta-alanine as a precursor) be appropriate alongside reducing TMAO? I have read about risks with TMAO as well, and had come to the carnosine conclusion earlier in my quest to stave off the likely inevability of increased CVD risk from my (healthy) low-carb diet and exercise, but from polling the opinion of this forum I got the feeling that most members have decided carnosine is not worth it, and could interfere with uptake of taurine (which they appear to find more important). Because of this discussion I now have a Kg bag of beta-alanine powder in my cupboard which I am hesitant to take, in part because I don’t want to take anything which I wouldn’t consider taking “forever” (also I like to layer things in slowly, and I just added 1mg daily oral finasteride several weeks ago with zero side effects thus far, including “interest/excitement” level). Also, since it doesn’t impact TMAO at all, if TMAO is found to benefit arterial AGE risks the use of carnosine shouldn’t negate potential benefits.

What is your opinion of carnosine to address your TMAO-related AGE concerns? And would it rank highly enough to make your “stack”?

As I see much of these lifespan/healthspan actions as trade-offs, I am focused on CVD as one area I would like to “overcompensate” for, given I am already addressing cancer risks with low-carb and metabolic health, and that the things that benefit with addressing cancer and CVD risk appear to improve blood flow and reduce kidney risks (so another major all-cause mortality risk being addressed) — now if I can just pay more attention when crossing the street. I have been considering a quarterly or half-year “pulsed” month course of Nattokinase as a protective factor for CVD plaque risks.

On the carnosine note, as I have a newly-diagnosed type-1 diabetic daughter, are there any thoughts on carnosine being appropriate for a 16-year-old to reduce the potential for AGE-related damage from serum glucose swings (inevitable for most T1D patients)? — her doctors have no opinion on this.

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#56

@Ericross2 These are good questions that I am not able to answer. I am lining up a podcast with Dr Jed Fahey to get into the AGE details. I’ll know more about it then. As far as my personal efforts to date, I am focused on getting my blood glucose to low normal (from high normal). I am also working to reduce my protein intake (from high to normal), which will mean less salt water fish (related to TMAO). In addition, I eat a lot more vegetables & fruits (many benefits), eat fewer eggs, use more balsamic vinegar (helps with NO as well), eat little dairy fat, eat no added fat or sugar (only what is in whole foods), eat no red meat (except for a hamburger 1x / year), avoid frying and grilling…maybe that’s enough.

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#57

That sounds terrific, @Joseph_Lavelle . Your follow-up on this is much appreciated. If I can throw another possible question out for your podcast: is AGE-cross linked blood vessel based damage (lower elasticity) a separate issue from plaque-based arterial stiffness? Or are they related? — I’ve been trying to get my head around this, as well as how to stave these off (the inevitability). Same question for kidney disease/damage. Thank you.

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#58

@Ericross2 thanks for the suggestion. I’ll add it to the list. In the meantime, this study describes the many causes of arterial stiffness, including cross linking and calcification.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308873/#:~:text=Arterial%20stiffening%20is%20a%20feature,cardiovascular%20risk%2C%20such%20as%20T2D.

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#59

I don’t think that’s relevant or proves anything at all, if I am going to be blunt.
MR is miles ahead of such a study in proving causality.

#60

I eat only what I like and it happened to be a healthy diet. I dislike all kinds of meat, sweets, cakes, ice cream, and alcohol. I love good home made food and cook a lot.