When it comes to reducing the effects of AGEs, it would be interesting to hear pros and cons for pyridoxamine vs Beta-alanine.(not aiming at taurine’s interaction with beta- alanine)
Being blunt doesn’t make you right.
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A nice talk that brings light on the question of low protein vs high protein.
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AnUser
#64
Well the study you cited is a mouse study. I cited a mendelian randomization study in humans which is like a natural RCT. They are two different leagues. The mouse study is near useless like all other mice studies, while the MR one is very powerful one able to assess causal relationships in humans. Likewise, mechanistic studies are very low on the evidence hierarchy, while MR is very high. This means the mouse study proves nothing and doesn’t give an alternative view, as it’s unable to do so by design. It’s just speculation for RCT’s or MR, which turned out false. It’s a hypothesis builder, not able to establish truths, and it was proven false by other ways.
Are totally with your process. I’m71 and have been on this path including annual nattokinase (neprinol 3x3 one month per year). I’ve been experimental on the diet and eschewing statins (“terrible” lipids, no plaques). I’ve been doing this for almost 16 years and have no physical issues. Fit and flexible. Workout with trainer 3x/week and do taiji the other 4 days (for 30 years). Married to 49 year old who can’t keep up with me 
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Abstract
Age is a risk factor for numerous diseases. Although the development of modern medicine has greatly extended the human lifespan, the duration of relatively healthy old age, or “healthspan,” has not increased. Targeting the detrimental processes that can occur before the onset of age-related diseases can greatly improve health and lifespan. Healthspan is significantly affected by what, when, and how much one eats. Dietary restriction, including calorie restriction, fasting, or fasting-mimicking diets, to extend both lifespan and healthspan has recently attracted much attention. However, direct scientific evidence that consuming specific foods extends the lifespan and healthspan seems lacking. Here, we synthesized the results of recent studies on the lifespan and healthspan extension properties of foods and their phytochemicals in various organisms to confirm how far the scientific research on the effect of food on the lifespan has reached.
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Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset
Diet may influence biological aging and the discrepancy (∆age) between a subject’s biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the ∆age of organs (heart, kidney, liver) and the whole body.
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Attia is so not a fitness guru, lol
He is specializing in what he calls Medicine 3.0 with the goal of lengthening health span as well as life span. He focuses on the #1 cause of death with is CVD. His fitness angle is also preventative.
AnUser
#69
More evidence for the Apple Inc. California diet. Less for the bible belt carnivore community, unfortunately. Flavinoids is the new antioxidants. 
I gotta have some “unhealthy” healthy food. I’m taking it from Michael Gregor who I have a love-hate relationship with.
High-Flavinoid “Ice cream”?
Just listened to this one and enjoyed it.
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Does anyone have access to PA exclusive content?
His latest newsletter is on protein and diet. This might be interesting to share for us all.
Dietary protein: friend or foe of healthy aging?
An endeavor to settle the debate of high- vs. low-protein diets for increasing lifespan and healthspan
A diet low in protein leads to frailty in old age.
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LaraPo
#73
Not so sure about it. My mother, almost 91, has been having a high protein diet all her life and nevertheless she has frailty. All of her friends with high protein diets are already dead - died in early 80ies. Having high protein diet which promotes mTOR is counterproductive imo. Older adults who are naturally less active do not need high protein diet.
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kansel
#74
I really think it has more to do what kind of protein. As an Example, when i consume organic steak, or wild trout/salmon i truly feel amazing, it almost feels as if i was taking some goods drugs with real positive effects lol. It doesn’t feel like eating food, kind of weird. But I don’t get that when I eat pork or chicken, or roasted lamb (which btw is my favorite food taste wise) as an example. Even though i really like the taste but no such good feeling.
At the end i think what’s most important is limiting calories to no more 1600 per day unless you extended physical activity or exercise
2. Intermittent fasting, i.e. eating only from say 4-8PM each day
3. Maintain a relatively low carb diet, eat mainly organic meat & wild fish, plus organic fats especially Olive oil
4. Get a good 8 hours of sleep daily
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My understanding is that extra protein (over RDA?) without need for extra protein is not helpful and possibly harmful. The key is to use movement & resistance training throughout life to trigger mTOR episodically, and then the extra protein will be put to a healthful use. Relatedly, the thinking on “anabolic resistance” was based on the observation that older people had less mTOR response to stimulus. Perhaps that was due to long-term over activation of mTOR leading to reduced function…? Even in younger people, eating protein to get a muscle synthesis response does not work very well if not paired with exercise. Does anyone have a different understanding?
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“A diet low in protein leads to frailty in old age.” How did you come to this sweeping generalization? Sure, the studies on protein for longevity are contradictory, but I dont think anyone is debating the value of maintaining higher protein consumption to prevent age related frailty and sarcopenia…
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Anchovies, rosemary herb, wine.
Acciaroli, Italy is a small town of about 600 people who smoke, don’t jog and are often overweight. But a whopping third of them are more than 100 years old, and 20 percent of that group is over 110.
What’s their secret? Research is still underway, but Dr. Alan Maisel, a cardiologist and researcher at the University of California, San Diego School of Medicine, told NPR it’s a mix of good genes and good diet.
More specifically on the diet front, researchers are tying this extreme longevity to consumption of two particularly, uh, fragrant ingredients. Maisel and colleagues at University of Rome La Sapienza noticed that the centenarians of Acciaroli all eat anchovies – a lot. And rosemary. Essentially, at every meal.
I like anchovies. Take a handful of dried Costco anchovies with my beer. Will have to develop a taste for rosemary. Maybe I will mix dried rosemary in my matcha tea, instead.
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Rosmarinic acid (in rosemary) is an HDACi
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There are other threads where i refer to HDAC inhibitors, but here is a more detailed post.
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