Spot on. Had he been malignant since 1991 he would have passed decades ago. Clearly, something made it malignant or whatever he was doing it didn’t help to stop it from turning malignant. But I’m sure he must’ve been doing many other things besides Rapa, so cant arbitrarily blame Rapa.
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LaraPo
#82
My long term cardiologist passed couple years ago from a tumor in the base of his head which appeared as a non malignant mass, was followed for 10 years as a non malignancy and one day it just turned into a very aggressive cancer. He wasn’t even 60.
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Yes, these things are puzzling, stays dormant for 10-20 years and all of the sudden it erupts into some deadly strain. I still think it’s more of an eruption if you will as opposed to a gradual progression. the question remains what triggered/triggers these dormant tumors to all of the sudden erupt?
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Thomas Seyfried argues a lot of cancers are mitochondrial in origin and they metastasise by causing the macrophages to get too many damaged mitochondria which are then spread. I think he is probably right. Hence up to a point the body copes, but after that the systems designed for protection cause harm.
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Nebil
#85
Continous mtor inhibition even with weekly dose will affect muscle development and cause bone marrow suppression. Would a weekly dose be considered cycling enough considering long half life? Howmany rapa users are paying attention to amount of protein they eat and resistance training in relation to day of week with rapa? Sarcopenia is probably as big a killer as any.
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The point about dosing and timing is that the trough matters. You need a period when the inhibition of mTOR is trivial or less.
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Doesn’t sound like he was sure. Sounds like he didn’t want to know so he didn’t look at it, and hoped it went away or stayed the same.
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Exactly. I consume protein every meal if possible. Dinner is always a pound of some kind of meat.
And that resistance exercise (me every other day) is key to turn that protein into muscle even when on rapamycin for 5-years.
I take my dose at bedtime, and I don’t go to the gym on the day after my rapamycin dose.
My muscle mass has been a constant size. See my avatar - pic from 2 weeks ago. Lol.
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It is a pricey peptide. I’ve done 2 cycles of FOX0 this past year. I have not done my usual Trudiagnostic test yet though so I can’t compare it to my previous 5 tests when I was cycling my personal senolytic formula every 3 months for the previous 4 years.
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I think this would be a easy fix, as most of us are already using therpies that treat that system, like clearing out senessent cells with 10g vitamin c, dmso, msm and so on. no chance for senessent cells post rapamycin to build up as you are constantly killing them off
vs this study that only gave mice rapamycin and nothing else
Jonas
#91
What are the two biomarkers?
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Hey Jonas,
I use two Bio-markers: GlycanAge a blood test for Inflammation, and TruMe a saliva test for epigentic methylation DNA. They measure very different areas of health.
In the two charts below you can see that my GlycanAge Inflammation went from low - up (November 10, 2022) on high doses 12 mg weekly of rapamycin – that was the only change in my longevity protocol. It also spiked on my TruMe test of DNA (November 20, 2022).
Two different bio-markers showing the same increase at 12 mg rapamcyin and then both also showing a decrease (in April 2023) once I took my dose back to 6 mg weekly. As you can see since keeping my dose at 6 mg no changes of the past 3 years.
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Jonas
#93
Thanks, that’s very informative!
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@Agetron Have you ever tried testing at 9 mg of Rapamycin. For you, 6 mg is better than 12, but what about the midpoint? You may want to try just for reference.
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Last week at 8 mg straight… no GFJ, side effect of clogged eye duct/ulcer lower right eye lid for 4 days.
Not good. Feels bad… looks worse. Hahaha. Today back to normal.
Will stay at 6 mg weekly for now.
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I am running a high level of mk7 at the moment so I cautiously took only 3mg of Rapamycin a few weeks ago just in case there was some form of conflict.
I think having high levels of mk7 will improve mitochondrial function and consequentially gene expression. As good gene expression is needed for effective autophagy I think they will combine in a good way rather than a bad way.
However, I have some uncertainties about the interplay between the PINK1/Parkin selective mitophagy with mk7 sitting in the membrane wall.
I do have the side effects that are measured with glucose and WBCs. (Hence I am going to avoid potential sources of infection for a couple of days). However, I don’t generally get the the nuisancy aspects of cancer sores etc.
I think that a result of two things. Allowing mTOR to come up again fully for a period of time and having a fully functioning immune system which reduces the level of background infection. Secondly the other things I do also reduce infection/inflammation.
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LaraPo
#97
Have you noticed if your Rapa dose influence your MPV (mean platelet volume)?
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If anything you might expect this to be lower. (In the same way as MCV goes lower), but these things are affected by quite a few things.
Sadly my main lab does not do MPV although the second one I use most of the time does.
LaraPo
#99
Mine is on a higher side consistently: 11 - 11.2 Some labs consider it abnormal. Usually up to 12 is within range. All other markers on my CBC with differential are very good. Don’t know if I should blame Rapa.
I will have new blood test in a few days - will see.
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