#101

Since the beginning of 2021, I have been taking relatively high doses of rapamycin and have seen little correlation between my bloodwork and my rapamycin intake. Most have changed very little in the last 4+ years, and that is probably a good thing.

As you can see, my MCV has changed little over time. I have no idea as to what caused the dips.

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#102

What about MPV (mean platelet volume)?

#103

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#104

Yours is stable and low, mine is elevated. Probably kidney then.

#105

Have you seen a consistent rise, or is it something recent?

I didnā€™t notice kidney problems listed as a cause, unless it falls under systemic inflammation and infection.

FWIW: from ChatGPT -o3 paid version

#106

Itā€™s a consistent number for a long time, not a recent change or spike. My lab flags it as abnormal every time I have cbc done. All other markers are nearly perfect. Seems I donā€™t have anything like in the above categories.

#107

Of course, I have absolutely no medical training, so I can only speculate or ask an AI like ChatGPT. I have a paid version, and I will be happy to enter any queries you might have.

FWIW:
Query
ā€œAre there people who consistently have a high MCV and MPV while their other blood markers are normal? Maybe due to genetics? And if one is high, is the other also likely to be high?ā€

ChatGPT response: Yes, there are individuals who consistently have both high MCV (mean corpuscular volume) and high MPV (mean platelet volume) while all other blood markers remain within normal limits. In many cases, this pattern is benign, may persist over years, and can have genetic or subclinical physiological explanations.

ā€œWhat if all other labs are normal?
If: No anemia, thrombocytopenia, leukocytosis, or signs of inflammation
Normal B12/folate/TSH/liver/kidney panels,
No alcohol abuse or medications known to alter cell volume (e.g., hydroxyurea, anticonvulsants),ā€¦.then persistent mild elevations of MCV and MPV can be considered benign.ā€
Some people consistently have both high MCV and high MPV with normal labs ā€” often due to genetic traits, benign marrow dynamics, or age-related clonal shifts.

I am just posting the bottom line summations. The actual answer is quite lengthy.

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#108

Thank you so much! It helps. My MCV is always normal between 87 and 89.

#109

I havenā€™t been here in a while but I still remember this study:

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy | Nature Aging).

6 Likes
#110

Yes, I remember this now.
All about gut health and immunities come from gut. Changes in eary adolescence carry on through life. Great paper. Jason

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#111

This was very helpful for me to read, so thank you for sharing this.

Iā€™ve had a nodule on my thyroid and lung for over a decade. My doc said now that they have been stable for so long, the protocol is to stop following them.

I donā€™t want to needlessly expose myself to extra ct scans, so I assume if I do a yearly whole body MRI will be enough to catch a change? Or is MRI just not sensitive enough?

PS
@LaraPo, Iā€™m glad you shared you use tremella powder and not pills. I just tried the powder, and as one who canā€™t even deal with the taste of creatine, tremella tastes fine! Two fewer pills a day for the win!

1 Like