#1

They can’t biochemically do it but maybe they make the body less prone to becoming super-rigid over time?

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#2

It’s a very interesting topic.

Enzymes that target crosslinks, particularly in proteins or tissues, are an area of active research. Some enzymes that have been studied for their ability to modify or break crosslinks include:

  1. Transglutaminases: These enzymes catalyze the formation of crosslinks between proteins, but they can also be studied for their role in modifying existing crosslinks.
  2. Matrix Metalloproteinases (MMPs): These enzymes degrade components of the extracellular matrix, including collagen, which can help break down crosslinked structures in tissues.
  3. Lysyl Oxidase (LOX): While LOX is primarily involved in forming crosslinks in collagen and elastin, its activity can be modulated to influence crosslinking processes.
  4. AGE-Breakers: alagebrium (ALT-711) - didn’t show success in human trials

(Copilot search).

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