Iām skeptical of any commentary by a person who says something is āmiracle grow for mitochondriaā. seems to be in hype mode.
Related Discussions:
Here: Mitochondrial peptides
Here: Anyone using peptides and rapamycin?
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Am taking with humanin later in the year, havenāt tried yet - but has entered my longevity stack spreadsheet 
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https://www.nature.com/articles/s41467-020-20790-0
MOT-C sounds very interesting but Iām not taking injections (yet) so most peptides are off the table for me.
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LukeMV
#5
Iād love to try MOT-S but a 5 week cycle of 10mg per week costs around $550
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Tim
#6
Yes, I have it in the fridge. Will try it when I finish a round of SS-31.
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Energy levelsā¦
10mg twice a day is his ideal dose (the doses for real effects are very expensive, highly unstable and quickly degraded
Insulin sensitivity
Acar
Ampk activation
Exercise mimetic
$5.10-7.60 per 10 mg from overseas
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MOTS-C adds at least 0.5 mph to my max run speed doing Norwegian 4x4 and I feel like I can go forever.
From Alzheimerās Drug Discovery Foundation
MOTS-c.pdf (450.8 KB)
CB4211 (MOTS-C) clinical trial, dosing 0.2 to 3 mg/kg/day:
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LukeMV
#10
Do the effects go away after you stop?
In terms of performance gains for me, yes, which is why I donāt buy it anymore. Maybe I didnāt run it long enough to see if it would actually result in persistent cardio performance improvements. Iād rather use tirzepatide for fat loss.
Functionally, it seems like a (maybe) non-carcinogenic version of Cardarine.
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Tim
#12
@AlexKChen
MOTS-c is not unstable and does not degrade quickly.
https://iovs.arvojournals.org/article.aspx?articleid=2782623
@AgentSmith āI feel like I can go foreverā
Me too.
@LukeMV
The spike in energy may be transient. I donāt know for sure. But MOTS-c does so much more in terms of gene expression and cellular metabolism. You should look at the CohBar papers posted by @AgentSmith. A lot its effects seem to be age-dependent, meaning that the older you are, the more you will benefit.
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Agree. Testing has debunked that claim.
Injectable carnitine 500mg 30 min pre running is a cheap and effective performance enhancer. Besides the infection risk from the injection, also pretty safe I would think.
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Iāve come close to purchasing that in the past. Have you used it with success? Does it produce lasting results if used consistently over a period of time?
(For anybody reading, carnitine is not to be confused with the cardarine that I mentioned earlier.)
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I would describe itās effect as making training āsmootherā / it feels just a little easier to push hard. If it produces lasting effects, that I canāt say yet, I have now used it around 4 times per week for 6 weeks, on my 2 endurance training days and on my leg & back strength training days. My strength is now where I want it to be, so now I am going to keep using it on my endurance days, because I am beginning to dislike the IM injections.
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It sounds like it is worth a try. I wonder if it has to be IM or if subq is okay. Maybe I will get a vial.
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Just injected 10ml or 10 units. 5ml is enough to dissolve it all. God the injection hurt but Iāll do less next time (it was hard to get the liquid into the 2nd syringe until it was 10ml
Enough to remember, not enough to suffer for too long, I mowed the lawn after
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