#92

I’m training for a marathon, and that includes a lot of leg strength training, so I take 12mg of rapamycin every 4 weeks at the beginning of my assimilation week which is a much reduced load week. The idea is to not block the adaptation during the 3 weeks of building phase but to take it during the recovery week to help with the cleaning up of the muscles.

4 Likes
#93

I am having the same problem, though I am not running marathons.
I think the problem can be addressed by timing. Currently I am trying a weekly pulsed dose of rapamycin, suppressing mTORC1, and then a day or two later increasing mTORC1 through exercise and diet.
This balance is especially important to me because I am trying to avoid sarcopenia.
So far this seems to be working. I measure biceps and quadriceps on a regular basis, and I am holding my own at 85.
What I don’t know is, am I blunting the longevity effects of rapamycin?

3 Likes
#94

FWIW:
I put together a rather lengthy, perhaps clumsy, query to ChatGPT o3 (Pro)
Query:
I’m having a hard time reconciling rapamycin use with a focused, maximum hypertrophy goal.
I am 85 years old. I am trying to maximize my healthspan and lifespan. My primary interventions are diet, exercise, and rapamycin.
I am trying a weekly pulsed dose of rapamycin, suppressing mTORC1, and then a day or two later increasing mTORC1 through exercise and diet.
This balance is especially important to me because I am trying to avoid sarcopenia.
So far, this is working. I measure biceps and quadriceps regularly, and I am holding my own.
Can you deduce from both scientific and anecdotal reports the proper balance and timing of rapamycin and exercise?

ChatGPt o3:
Putting it together
The emerging picture is not “rapamycin versus muscle,” but “rapamycin plus carefully timed mechanical and nutritional pulses.” Intermittent (weekly) dosing exploits the drug’s long half-life to reap geroprotective signalling while still leaving ≥ 3-4 days every week in which mTORC1 can fully drive muscle repair and growth. Preclinical evidence, early human trials, and community reports all converge on the same practical guideline: dose, then wait ~48 h, then lift heavy, eat protein, and grow.

Of course, the complete response was quite lengthy, but the summary addresses the final result.
Fortunately, that’s what I have been doing.

3 Likes
#95

FWIW, I too settled on the same schedule. I dose Saturday 10 am, and do weights (actually circuit training) Monday, 50-52 hours later. BUT I do a pretty hard core rucking Sunday 1 hour in the hills. Muscles seem to grow, no issues.

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#96

A bunch of people tagged me. Tag back: @AustraliaLongevity @desertshores @cl-user

This is my very long-winded write-up, but I write to think, so it is what it is. I’m about 33% in sync with you, but I landed on a different overall approach that’s more cyclical and variable than the more common static approaches.

Of course, this is a very tricky subject with many variables, and there’s a lot of room for personal preferences and drug responses. So take this as a description of where I’ve landed for myself rather than as an attempt to prescribe an approach for anybody else. Still, it might inspire something for someone else, and the data are interesting to me.

It is long and detailed, though, so I’ll be amazed if anybody reads it to the end!

Data

  • My personal sirolimus half-life is ~54 hours for the exponential decay part of the curve. That is based on an 8mg dose with some nuts, no grapefruit. Eris/Biocon brand.
  • Single 8 mg dose: 23.33 h = 3.5 ng/mL, 71 h = 1.9 ng/mL.
  • Model that matches my labs: C(t) = 0.590 × dose(mg) × 2^(−t/54) (ng/mL).
  • We will normalize some doses by my body surface area (BSA)
    • BSA normalized: 8 mg ≈ ~4 mg/m², 6 mg ≈ ~3 mg/m², 5 mg ≈ ~2.5 mg/m².
  • Now, please reference the well-known blood concentration curve.
    • The red stars are my lab results adjusted for BSA.
    • The green star is a prediction at 84 hours (more on that later). 1.61 ng/mL
    • The blue triangle is a 48-hour prediction based on a normalized 5mg dose. 1.59 ng/mL
    • The purple square is a 48-hour prediction based on a normalized 6mg dose. 1.91 ng/mL

curve
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  • Note how well my red stars follow the 5mg/m2 dose curve, though my BSA-adjusted dose was 4mg/m2. I will attribute this to different sirolimus formulations, my absorption of the drug, and variability in the BSA calculation, which is only an estimate.
  • So why the green, blue, and purple calculated datapoints?
  • Well, as stated elsewhere, I’ve run resistance training experiments at different doses and I’ve logged workouts for years. I have a decent sense of what is normal for me from week to week.
  • This is what happened during resistance training:
    • At 5mg, 48 hours after the dose, my estimated blood concentration was at 1.59 ng/mL (blue diamond), and my training sessions seemed normal. Typically, that would involve some small progression of volume or load.
    • At 6mg, 48 hours after the dose, my estimated blood concentration was 1.91 ng/mL (purple square), and I was clearly a little bit weaker the first session of the week, but I did better as the week went on. I still progressed week-to-week.
    • At 8mg I was still weaker 84 hours after dosing, with an estimated blood concentration of 1.61 ng/mL.
    • I went back and forth a little bit between doses to verify that the effect was real.

Conclusions about dosing

  • How can we explain being fine at 5mg and 1.6 ng/mL but not fine with an 8mg dose at the same blood concentration 36 hours later? I am guessing that it’s the area under the curve and the time above the therapeutic dosing level, which we’ll assume is the purple line at 3 ng/mL.
    • Note that there is very little time above 3 ng/mL for the 5mg dose, assuming that the blood concentration scales linearly with dose. (It appears to on the plot and that would make sense to me if absorption isn’t dose dependent, but somebody smarter can correct me on that.)
  • What I don’t know is what threshold I would have to drop below at an 8mg dose to be at full strength during training. I’m arbitrarily assuming something closer to 1 ng/mL.
  • Note one more thing: To get above 3ng/mL for ~30% of the week, a goal discussed on this site, I would need a 10mg dose, which implies a very long RT interference period.
  • Is this consistent with others have observed? I think so, because most here are taking relatively low doses. At the common 6mg/wk, recall that I experienced a relatively minor impact on my training, but I was still able to progress week-to-week. Clearly, there was some inhibition for me at 1.9ng/mL at T+48 hours, but it only slowed progress rather than halting it. So when others on the forum speak of being able to build muscle, or at least not regress, on similar doses, I believe it. I also think the progress being made is not what it could be if rapamycin were not in the picture.

What to do with this information

  • What I wanted to do is determine how to apply these data to construct a training program that would also allow for regular rapamycin administration.
  • The open question is when and how much to dose relative to training sessions that must meet some requirements.
  • Of course, requirements vary with the objective. Do we want maintenance, slow-progress, or maximum hypertrophy or strength? Regardless, some of the constraints are the same, so let’s start there.

When to dose relative to the last resistance training session of the week

  • The first thing I want to consider is when to take rapamycin relative to the last training session of the program cadence – let’s assume it is a program that aligns with weekly boundaries. Though 7 days is an arbitrary number, this kind of programming is the most common.
  • What I want to consider is how long muscle protein synthesis can remain elevated after a good training session, assuming I am in a well-fed state with adequate protein. I am using a couple data points to derive some boundaries.

When to dose relative to the first resistance training session of the week

  • The next thing I want to determine is how long I need to wait after dosing to have my first resistance training session of the week. This is obviously dose-dependent, and this is where I run into even more trouble.
  • Consider this notional scenario:
    • Day 0, 10 a.m., just finished my last RT session of the week. Now I wait 36 hours before dosing – here I am compromising on muscle protein synthesis.
    • T+36 hours, call this Day 1, at 10 p.m., I take rapamycin.
    • Now I am at the point where I know I can take a 5-6mg dose and have little to no perceived interference 48 hours later… yet I really don’t want to workout at 10 p.m. I have a few options: drop the dose even more, tolerate more interference by moving the workout inside the 48 hour window, or shift the dosing time earlier in the day on Day 1. No matter what, there is a compromise to be made.
    • Let’s say I want to be cautious and I drop the dose down to 4 mg but keep the timing the same: at best, I’m getting a few hours (maybe minutes?) above the 3ng/mL therapeutic level. It isn’t even worth taking rapamycin!
    • That isn’t an option. I want at least some appreciable amount of time, so I’m really back at a 6mg dose. The half-life calculation suggests I’d have about 13 hours above the therapeutic serum level. I know the pharmacokinetics aren’t that simple, but that’s the best I can do.
    • The question of whether this is even worth it remains. I get a few hours above 3ng/mL, and at the 48 hour mark I’m at 1.9ng/mL and feeling the effects, so I believe it did something. But is it enough? I don’t know. If I think of it as a caloric-restriction-mimetic, a 13 hours fast isn’t a big deal. I’d like to have at least 24 hours above 3ng/mL. Yet that implies that I need to take something closer to 7mg+, and then AUC becomes a problem, so I would have to push my first training session to the right.

Training program challenges

  • Why push it to the right? Well, I don’t want to waste time training if I’m not going to get a good response or if I’m too weak to elicit a good stimulus.
  • Now pushing it to the right might be fine except that I start to run into training programming issues. I’d have to drop from my present Upper, Lower, rest, Upper, Lower, rest, rest cadence to perhaps something like total body 2 days a week. Regardless, progress might be impeded.
  • An alternate might be to just forget about the arbitrary weekly boundaries, but again, muscle group training frequency would decrease over any rolling time window.
  • I think what I would do for a slow-progress goal is keep my 4 days of training per week and accept that I’m not getting nearly as much as I could out of rapamycin by essentially baby dosing at 5-6mg. I don’t like this at all.

Now what if my goal is maximum hypertrophy?

  • This is much easier to think through because for this goal I want to maximize mTOR: I’m eating in a caloric surplus, eating a lot of protein (lots of leucine!) at frequent intervals, and I am unwilling to sacrifice muscle protein synthesis.
  • In other words, for maximum hypertrophy I am all in and there is no place for rapamycin. It is completely incompatible with this objective.
  • At this point I wonder what I’m left with. I can’t use rapamycin when I’m in a hypertrophy phase, and the dose I can tolerate in a slow-progress phase is so low I’m not sure it’s worth it.

So what dose do I really want?

  • Well, 8-10mg gets me into the therapeutic range for about a couple days, which is pretty good. However, I know that it would interfere with resistance training for several days. Would that ever be okay? I think so, if my goal were simply to maintain muscle, because I wouldn’t need to train as frequently (say even one full body workout once a week). However, I could actually train more than one day a week with a higher dose if I consider another variable, as follows.
  • With large doses, I would want to let my blood concentration drop back down to a very low trough level, so I would lean towards allowing 5.5 half-lives to elapse before dosing again. For simplicity, this means a 2-week cadence. The majority of the first week (probably 5-6 days), I am just doing cardio. After that, I do whatever resistance training routine I want, and I try to hit it frequently. Over, say, 8 days, I can get several training sessions in.

Final Conclusions

For me, rapamycin makes the most sense during a maintenance phase, and it makes no sense during a hypertrophy phase. It makes a little sense, but only a little, during a slow-progression phase.

So what do I want to do? I think I want to cycle through these three phases. Hypertrophy phases should be the shortest because I don’t want to live in mTOR-land for too long. Rather, I want to spend most of my time in the compromise zone where nothing is perfect, but I’m hedging my bets, banking on getting some small benefit from rapamycin while still building a little bit of muscle. I also want to spend some time in AMPK-land where I just try to maintain what I built up in the other phases, perhaps drop any fat I accumulated in the hypertrophy phase, give my body a break, enjoy autophagy, become cardio-guy. Here, I change to a cadence of every other week with higher doses and some unusual resistance training programming that is very close to one week on, one week off. In this phase, I know I’m getting something out of the high-dose rapamycin, but I also want to keep this phase relatively short because I’m not fully convinced that it’s good or necessary to constantly hammer mTOR into oblivion. I recall Matt Kaeberlein’s discussions about this.

Once I reach a muscle mass objective, I can drop hypertrophy phases, or they become very infrequent. At this point, I monitor how I’m doing with DEXA scans and spend my time in the other two phases. I think a lot of people on the forum are actually in this general zone, satisfied with their level of musculature.

Essentially, what I have described looks a lot like bodybuilding phases but with rapamycin incorporated at variable doses and durations. This approach hedges bets and emphasizes different pathways. Given that we really don’t know how to optimize the use of rapamycin, I like the idea of mixing things up.

10 Likes
#97

One argument for rapamycin + training + TRT = hypertrophy and health:

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One thing I think that makes the weekly rapamycin use + exercise better is if you do whole body workouts or basic upper/lower split at least 2x a week like I do. That way any negation of hypertrophy and strength gains from rapamycin is offset by the fact that the same exercises and muscle groups are worked more than once.

This also comes to mind:

I know we’re not female mice but it is promising.

Ultimately if you want to pack on a bunch of muscle in a short period you’d likely do it faster without rapamycin, but I don’t think it would be terribly detrimental on a steady maingaining plan. You could even do fortnightly doses instead of weekly temporarily if you wanted to experiment.

I’ve done this before. I’ve gone through phases where I’ve intentionally activated mTOR/AMPK in the context of an overall longevity focused lifestyle and it felt beneficial. I’d never want to sustain that long term but it helped recovery.

2 Likes
#98

That’s great that you figured out what works best for you. We are all different, and what works for one person, doesn’t necessarily for another. I break down rapamycin quite differently. I take only 6mg once a week, and at 50 hours I’m still 5.6 ng/mL. How my muscles respond to an exercise program is not how yours do. It also depends on where you are in your program - are you starting out with weights, or have you been doing it for 20 years. And so on.

The truth is, that everyone needs to work out for themselves what works for them, and there is very little utility in following someone else’s example or program.

But it’s exactly as you stated: your methodology may not work for someone else, but it could be an inspiration as to how to approach these issues.

So thank you for putting in all this work, it’s pretty thought provoking and we can utilize what you found for our own purposes. Thanks again!

4 Likes
#99

FWIW: I posed the question to ChatGPT-5 thinking mode.
Of course my goal is to maintain muscle mass, which I think I have enough of, while still reaping the benefits of rapamycin.

" Short answer: yes—it’s reasonable to get rapamycin’s benefits and still progress on hypertrophy if you cluster your heavy training ~48–72 hours after the weekly dose and keep the first 24 hours post-dose free of hard lifting. That pattern lines up with the drug’s pharmacology and the human data we have so far.

Why the 48–72 hour gap works

  • Acute blockade is real. A single dose of rapamycin given just before lifting abolishes the normal post-exercise rise in muscle-protein synthesis (MPS) in humans—so hard resistance work in the first 24 hours after dosing is poorly used. PMC
  • But the effect is transient. Sirolimus has a terminal half-life near 60 hours; as concentrations fall, mTORC1 signaling responsiveness returns. Practically, that means the MPS “block” is strongest the first day and fades over the next 1–2 days. PMCClinical Therapeutics
  • Intermittent (weekly) dosing hasn’t hurt lean mass in older adults. In the 48-week randomized PEARL trial, once-weekly rapamycin was safe and women on 10 mg/week saw significant increases in lean tissue mass; no lean-mass loss was seen overall. While not a training study, it argues weekly rapamycin doesn’t inherently waste muscle in older adults. PMCPubMed
  • Exercise + weekly rapamycin is being tested directly. A 13-week randomized, double-blind trial in older adults is evaluating once-weekly sirolimus combined with an exercise program—a formal version of the “dose → wait → train” approach you’re using. BioMed CentralPubMed
  • Mechanistic reviews agree timing matters more than the drug per se. Geroscience reviews note rapamycin can blunt the acute MPS spike if present at the workout, but hypertrophy also draws on rapamycin-insensitive pathways and longer windows of elevated MPS, supporting a separation-in-time strategy. BioMed Central

A weekly template that balances both goals

Day 0 (dose day)

  • Take rapamycin (e.g., morning). Skip heavy lifting; do mobility/walking only. Keep protein modest and spread (avoid big leucine hits you can’t use while mTORC1 is blocked). PMC

Day 1 (≈24 h post-dose)

  • Light cardio or rest. Begin normal protein intake but save your heaviest training for later. (Drug levels are falling but still high enough to blunt the workout’s payoff.) PMC

Days 2–4 (≈48–96 h post-dose)

  • Primary hypertrophy window. Schedule 2 big sessions here (e.g., lower- then upper-body), hit 6–12 reps × 3–4 sets at 70–85% 1RM, and anchor a ≥0.4–0.5 g/kg protein feeding within ~2 h pre-or-post each session. This is when your muscles can actually “spend” those amino acids. PMC

Days 5–6

  • Optional third lighter session (power, balance, or accessories) or recovery. Then repeat.

Fine-tuning

  • If your dose is higher or you metabolize slowly, shift lifting to ~60–72 h post-dose. If you ever check a week-trough level (day-6) and it’s >~5 ng/mL, extend the wait before heavy sessions. (Typical adult half-life ≈60 h; higher exposure lengthens the “blocked” window.) ScienceDirectClinical Therapeutics
  • Protein strategy on training days: 30–40 g high-quality protein within ~2 h before or after, plus two more meals that each hit the ~3 g leucine threshold (≈≥30 g high-quality protein), and a slow-digesting pre-sleep serving if you tolerate it. This pattern is repeatedly shown to overcome anabolic resistance in older lifters. BioMed Central
  • Evidence check, big picture: Humans: rapamycin blocks MPS only when “on board” at the workout; weekly dosing over 48 weeks did not reduce lean mass and even improved it in one subgroup. Animals: chronic/frequent dosing can blunt adaptations, but intermittent strategies don’t uniformly do so—and some new mouse data suggest exercise adaptations can persist with rapamycin when timing is managed. PMC+1Wiley Online Library

Bottom line

Your current “pulse rapamycin → wait ~48–72 h → lift heavy & eat for growth” strategy is exactly how to square longevity benefits with hypertrophy at 85. Keep the first 24 h after dosing as no-lift time, cluster your hard sessions in the mid-week window, and you can preserve (and often build) muscle while still harvesting rapamycin’s upside. PMC+2PMC+2
"https://physoc.onlinelibrary.wiley.com/doi/10.1113/jphysiol.2008.163816

5 Likes
#100

Buried in my manifesto was that I am also doing that exact split. I would say my personal finding is simply that, yes, I also found that 2x a week frequency allowed for gains at a relatively low dose (for me: 6mg), but I would not use the words “any negation” and “offset,” because my capacity for workload was lower earlier in the week. That means less progress vs. a no-rapamycin baseline. So for my physiology and at that dose, I would instead say that 2x per week frequency mitigated some of the negative effects of rapamycin, but not all. I’ve been training for years - not a beginner.

(I too, am on TRT, by the way, and experienced interference with very high free T, perhaps too high at times.)

I think the general consensus after months of discussing this in various threads is that individual variation is so great, both in terms of response and objectives, that trial and error with good record keeping is the only way to figure out what is going to work.

Now as for studies, those we have are not very useful to me when it comes to practical application, and not just because they may be studies of animal models instead of humans. It’s that individual variation is so great that I don’t think the studies are going to tell any of us how we are going to respond to stimulus and drugs. The same problem exists with the so-called “science based lifters” in the fitness community. The science provides some general guidelines and points to trends that can help guide program design, but, again, there are so many factors that go into a resistance training response that one still ends up having to try a lot of things over very long periods of time to find out what works best. Volume, load, tempo, frequency, diet, genetics, biomechanics, training history, age… they all matter.

\

We certainly agree in a general sense, and I said something similar in my writeup, but you would probably agree that the key words there are “terribly detrimental” and “maingaining.” Ultimately, I think everybody agrees that if rapamycin inhibits mTOR, it is going to have some dose and time dependent effect on hypertrophy. So we should decide on an objective and plan accordingly, but not engage in wishful thinking that denies mechanisms: “I can take all the rapamycin I want and still build muscle at the same rate.” Nope, not if mTOR is involved! Not if rapamycin actually works! That comment isn’t aimed at you, it’s just a kind of thinking that has circulated to some extent on this forum in the past.

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#101

Right, it seems that that should be the place where we spend most of our time because it’s the sensible, hybrid compromise that provides some benefits of both, really by doing mini-cycles within a week. We some benefits of rapamycin and some benefits of resistance training but I don’t think we get the maximum possible benefit of either. Maybe that’s okay for most people, though. Good enough is good enough.

And at 85, I doubt most are concerned with getting jacked. I consistently read your posts and think “I hope I’m in as good a shape and as mentally sharp if I can reach 85.”

5 Likes
#102

Damn… Matt is looking very “SPARTAN”
His TRT for muscle growth seems to be working. :stuck_out_tongue::wink:

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#103

I would even venture to say he’s “jacked” :wink:

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#104

Not sure I would necessarily presume rapamycin inhibits muscle growth (even if that seems mechanistically plausible). Completely speculating here but I’m guessing Brad Stanfield’s study will suggest the opposite

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#105

I agree, caution is advised, biology tends to keep surprising. Brad’s study - it’ll be interesting to see the protocol.

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#106

He was pretty muscular before. Remember when he did his DEXA? I think his percentile was already 90+ and he was in the low teens for bodyfat.

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#107

I don’t know, I guess we’re all speculating but to me that falls into the wishful thinking bucket. I hope we learn something from Brad’s study but I don’t know how applicable it will be outside of the elderly population. I don’t know if they’re trained or untrained. If untrained, that would make it even less relevant. I’d like to see a study on 30-50 year old very well-trained men without appreciable anabolic resistance who have healthy muscles (not laced with fat) and are metabolically healthy. Have somebody who knows what they’re doing execute the study: Brad Schoenfeld. Maybe Brad Stanfield will show that rapamycin repairs a broken process in elderly people that then allows them to start putting on muscle again, but that’s a special population and he’s starting from a suboptimal state. I think we’ll learn very little.

My argument as a younger person is that if it reduces my ability to progress my workload, or actually causes it to regress early in the week after dosing, and I’m very confident that it does this, it is inhibiting muscle growth because I’m not giving my muscles the same stimulus that I could get without it. Progressive overload is slowed, and therefor muscle is accruing at a lesser rate. I concede that the effect may be small if we time the dose well, but to say there’s no impact seems like a real stretch. And if I have to adjust my training to avoid mTOR inhibition, it is slowing muscle growth relative to what would otherwise be possible. That’s not mechanistic, but the end result is the same in the real world where it matters - I don’t live in a petri dish. :slight_smile:

But regarding mechanisms, how do we get around this study? Yes, they’re talking about substantial doses and brief windows, but we can’t deny that the impact on MPS is real. Anyway, I’ve made my case. There’s not anything else to add. I actually have to go do leg day right now.

Rapamycin is inhibiting my muscle growth by causing me to spend time debating it on the internet with strangers rather than do leg day. :slight_smile:

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis - PMC>

The novel findings from this study are the following: (1) the increase in human muscle protein synthesis during the early (1–2 h) post-exercise recovery period is abolished by rapamycin administration prior to exercise; (2) the exercise-induced change in the phosphorylation of a majority of proteins in the mTORC1 signalling pathway (i.e. mTOR, S6K1, rpS6) were delayed with rapamycin treatment; and (3) rapamycin completely blocked S6K1 (Thr421/Ser424), eEF2 (Thr56), ERK1/2 (Thr202/Tyr204), and blunted MNK1 (Thr197/202) phosphorylation during post-exercise recovery.

7 Likes
#108

You wrote: “Maybe Brad Stanfield will show that rapamycin repairs a broken process in elderly people that then allows them to start putting on muscle again, but that’s a special population and he’s starting from a suboptimal state. I think we’ll learn very little.” Exactly!

Kind of like the PEARL study - great idea, but when they start off with inferior product rapamycin - Wha - Wha -Whaaa!! :wink: https://www.youtube.com/watch?v=lAiI_Vbt5V8

2 Likes
#109

@AgentSmith FYI, here is what I get when I run my rapamycin PK model on your values:
image

Basically it finds a slightly higher half-life than you because the first point at 23.33h is still a little bit before the equilibrium. That’s why I prefer taking the first point at 48h just to be sure.

This is similar to what I’ve observed myself and I have been using a training schedule similar to yours but then recently, I’ve been thinking that it leave too little time for training in the remaining of the week.

This is why I’ve now started to use a 4 week rapamycin cycle like so:

  • Week 1 - No Rapamycin: Training normally
  • Week 2 - 6 mg Rapamycin: 3 Day pause then training normally
  • Week 3 - No Rapamycin: Training normally
  • Week 4 - 12 mg Rapamycin: 5 Day pause then training normally. That’s assimilation/recovery week

Another way to see it is

  • 6 mg Rapamycin: 3 days low activity
  • 11 days of normal training
  • 12 mg Rapamycin, 5 days low activity, 2 days moderate activity (assimilation/recovery week)
  • 7 days of normal training

That forces me to plan the training to be sequences of 11 days and 9 days between the rapa intakes but I kind of like it in fact.

I can also adjust it by skipping the 6 mg intermediate dose if I want to train more or bumping it up to 12 mg if I want to train less.

3 Likes
#110

Thanks for running my numbers through your more sophisticated model. I’ll adjust the test timing next time.

I like your training and dosing plan. What kind of results are you getting?

#111

They should have asked the community for feedback first, just as Brad should have. But doctors know better than the rest of us… :thinking:

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