I just saw a research presentation last week on how taurine binds to GABA receptors and is a major factor in reducing hyperactivity in mice: the experiment showed that with taurine-deficient “knock out” mice they were hyperactive, but supplementation with taurine significantly reduced their hyperactivity (measured in mental performance, maze running, and actions). Im not a mouse psychologist (or a human psychologist) but it sounds like the mice reaction was the opposite of what you see. I dont think the research has yet been published so no reference available.
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I have the impression that I can not think “clear/streight” when I take taurine in the morning. Also about one or two hours after taking it. It was horrible at work when trying to think about issues.
I stopped taking it on weekdays. And yes I also only take it in the evening now.
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I love the anecdote of the 82 yo lady who couldn’t play tennis anymore. After taking Taurine, she was back on the court!
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José
#64
FWIW
Those who are interested.
The person speaking is Dr. Mark Rosenberg MD.
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Easy enough to try! Right now I take 2g per day. I’ll push it to 10 and see if I feel like Superman w/diarrhea (Super Diarrhea Man?)
. UP, UP AND A UH OH
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Hmmm… been on Taurine for awhile on my second bag… ordered it from Amazon.
I put in my morning coffee… one teaspoon, so about 5.6 grams.
Maybe up it to 2 teaspoons after listening to Dr. Mark Rosenberg. Thanks.
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How is your experiment with Taurine going? In my case, T has a small positive effect on my maximal performance in endurance activities. I find that T is an additive (performance enhancing supplement) to coffee. I have coffee with 1.5 grams two hours before maximal effort, or Coffee with 0.5–0.7 grams 30 minutes before exercise.
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I’m not pretty sure. Seems compareable to your results but I’m absolutely over-worked ATM, so I can’t be sure if it is Taurine or just a little recovery.
I’m on 5-6g 1h befor going to bed. If I’m exhausted from sports it seems that I have a faster recovery or just feeling lesser exhausted or so.
I don’t think that I have performance gains like feeling in the first place.
But I have seen enough to ask my mother to try it and eventually include it in my shop.
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Has anyone here received anything like the benefits that Dr. Rosenberg describes in the video?
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I’ve been taking 8g per day for about four months now, and haven’t noticed any effects at all.
I guess you could take it as a sign that you are incredibly healthy/young. 
Maybe I need to practice more stoicism. 
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Does creatine increase mTOR? But we’re taking Rapamycin to inhibit mTOr?
Melih
#73
With situations like these… if compound x increases mTOR but has a myriad of different beneficials effects besides increasing mTOR, keep taking compound x and just increase the dose of sirolimus/rapamycin which is a clean mTOR inhibitor.
What I’m trying to convey is; if in doubt (and no side effects) think about increasing the dose of your mTOR inhibitor.
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Another rat study on diabetes and Taurine.
Taurine appears to be highly protective against the effects of diabetes.
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TARM
#75
I saw someone mention taurine and glycine interfering with each other. This stems from the fact that taurine has a high binding affinity for the glycine recptor. Based off this, just to be safe, I seperate any dosing of the two. I had been rotating glycine and taurine before bed. Lately I have been using only taurine at night as I find of the two it helps me the most with my sleep. I also use glycine for its effect as a inteacellular osmolyte in workout and hydration drinks. I would add taurine as well if they did not target the same gyl receptors.
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Interesting information that you find it HELPS with sleep if taken before bed.
I always assumed it increased energy (being used in all the energy drinks and pre workout powders)
I was taking it before the gym
Can anyone else confirm evening dosage and sleep results
Thanks
In my case, I get the best results for my sleep when I take 1,5 - 2,5 gr taurine. If I take more, I tend to wake up in the middle of the night and when I get back to sleep, my sleep is of low quality. And I can have brainfog when I wake up.
This triple combo is very effective for most people:
L-theanine, GABA, Taurine.
L-theanine, plus GABBA reduces sleep latency.
Taurine extends sleep time.
I don’t know the exact combo that is most effective, but based on my reading of peak time and half-lives, I take l-theanine and GABA approx. 45 minutes before bedtime to reduce sleep latency and taurine right at bedtime to extend sleep time.
I would also add to extend sleep time without having to get up in the middle of the night to go pee, severely limit your liquid intake after 6 PM
“GABA and l-theanine mixture decreases sleep latency and improves NREM sleep”
'GABA/l-theanine mixture has a positive synergistic effect on sleep quality and duration as compared to the GABA or l-theanine alone."
From Bard:
“Taurine and GABA are both compounds that may help with sleep. Taurine is a natural compound that increases in response to being awake, and it activates GABA(A) receptors in the brain. GABA is the main inhibitory neurotransmitter in the central nervous system, and it’s distributed in most areas of the brain. GABA levels increase when taurine does, which may promote a calming effect. GABA also slows down certain brain functions, which may help with stress reduction, anxiety relief, and improved sleep quality. Taurine may also interact with GABA receptors to inhibit neuron excitement.”
“Sci-Hub | GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical Biology, 57(1), 64–72 | 10.1080/13880209.2018.1557698”
“Sci-Hub | Interrelationship between Taurine and GABA. Taurine 3, 329–337 | 10.1007/978-1-4899-0117-0_41”
“Taurine and GABA neurotransmitter receptors, a relationship with therapeutic potential? - PubMed”
“Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics - PMC”
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LaraPo
#79
What doses of the three are you taking?
I take 4 grams in the morning and 6 grams right before bedtime.
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