Dr. Attia on Taurine

[DeStrider]

@Joseph_Lavelle

Just for you, Joseph. Dr. Kaeberlein on Taurine

Is Taurine Worth the Hype & Does it Really Slow Age?

[Agetron]

Like Kaeberline’s response on Taurine as a second tier intervention for health and longevity. Seems to be favorable. I will see how this improves my bone density in December when I have my two years bone scan done ($700 - free with insurance).

Matt Kaeberline says anecdotally – He knows many that have tried all forms of dietary interventions and calorie restriction, etc… “the changes in the people who adopt a low protein diet (in my view) look sickly and frail – they look weak.”

I agree that high protein helps me maintain a good BMI, have strength, great gut biom and feel healthy.

[desertshores]

Though I like Dr. Kaberlein, he is about 7 years older than Bryan Johnson and looks it.

My prediction, that you can put in a time capsule, is: that Bryan Johnson will die at an older age than Matt Kaberlein.
Why? Out of an abundance of caution, even more so than Dr. Brad Stanfield, he doesn’t take taurine as well as many of the other possible life-extending supplements.

I think, because of his age (~53), his window is narrowing for maximum benefits of life-extending compounds. From his video, there don’t seem to be any downsides to taking a taurine supplement.

[Joseph_Lavelle]

@DeStrider Thanks! I actually saw this one already. Matt Kaeberlein is my favorite scientist. I find his thought processes to be very helpful to me. I recognize that he is conservative. He says on Taurine…probable upside and no known downside…yet he doesn’t take it. Why?

I have looked carefully in the last 12 months at the scientists who are involved in the longevity research (the names we’d all recognize). Many of them are cautious about drugs and supplements. Why?

I don’t know for certain but they often talk about the interactions between drugs is unpredictable and often negative. Well, it makes me nervous so I’m try to be cautious as well when it comes to chemicals I add to my diet. I’m even more conservative about drugs that get injected into my body.

I am entirely not cautious about: R/IR light therapy, exercising, getting too much sleep, laughing out loud, and enjoying “man’s best friend”.

[DeStrider]

@Joseph_Lavelle I would agree with you for the most part. However, I do feel that substances our bodies become deficient in should be supplemented. This includes vitamin D3, B12, Magnesium and Omega-3s when we are young. Once we hit 40-45, we start to become deficient in a whole new set of substances such as glycine, cysteine and taurine.

As Dr. Kaeberlein says, “Cure deficiencies first!”

Cure Deficiencies First (Matt Kaeberlein & Bruce Ames)

After listening to the latest talk from Dr. Kaeberlein and reading the works of Bruce Ames (95 yo Biochemistry Professor UC Berkeley), the one thing that stuck out was that he said to cure your deficiencies first for healthspan and longevity. After that, exercise, sleep, diet, and socialization are important. Finally supplements. So, I thought we should create a thread to list things that most/many people are deficient in and ways to treat it as this is the first step towards longer lifespan\healthspan and we often overlook it. I’m going to start off with the two biggest deficiencies I know of: 1. Omega-3s - 70% of American adults and 95% of children do not get enough Omega-3s. Low EPA and DHA levels in red blood cells were found to be associated with increased all-cause mortality in a study of 6,501 elderly women followed for 14.9 y (32). A metaanalysis reported that each 1% increase in plasma DHA/EPA was linked with a 20% decreased risk in all-cause mortality (33). Low bloo…

[Joseph_Lavelle]

Agreed! I would act on measured deficiencies. I’m trying to avoid acting on the imagined or just statistically probable deficiencies. I just think there is NOT zero downside for combining chemicals. That’s why I limit myself, but I still take a lot of chemicals (pharmaceutical and supplements); it bothers me. If I want to get extra nutrients for insurance, I’ll eat more foods with the nutrients. My belief is my body can deal with it better that way.

[Deborah_Hall]

It is interesting that you take Taurine both morning and bedtime. I had read that Taurine and Glycine can cancel each other out so I decided to take Taurine in the morning so I could take Glycine or GlyNac (as well as Magnesium Glycinate) at night as I thought Glycine would be good for sleep. But do I have it right? would it be better the other way around?

[LaraPo]

Dr.Kaberlein didn’t do all procedures for skin rejuvenation, like BJ did, and looks naturally and age appropriate. Because of many cosmetic procedures that BJ went trough, it’s not fare to compare him to Dr Kaberlein. It would be comparing apples to oranges imo.

[AnUser]

@desertshores

My prediction, that you can put in a time capsule, is: that Bryan Johnson will die at an older age than Matt Kaberlein.

I think Bryan has a higher risk of having a mental breakdown than Matt.
I might be throwing stones in a glass house though. But it might be the other side of the coin and a risk that comes with the territory.

Just an observation of some inconsistencies, like talking about god tier AI on the horizon yet he’s spending a lot of money and time on longevity despite being 46 years old. He’s talking about creating a religion and a belief system, and seemingly that it is superior to others. I just get that cult vibe, in the end it’s a merry-go-round and he’s going to be back where he started.

Or that Bryan is doing cosmetic treatments like lowering CR% for higher facial fat I think, and getting veneers (a cosmetic treatment for teeth), wearing childish clothing, just some inconsistencies, what is his mission?

[LaraPo]

@AnUser

what is his mission?

The mission is to create an illusion of age reversal.

[desertshores]

Yes, I think Bryan Johnson is something of a nutter but he is at number three in the rejuvenation olympics. He has a good medical team. Matt Kaberlein is not apt to be smarter than all of them.
There is no way to account for genes. Maybe, if enough people entered there would be someone at the top of the list who isn’t doing much at all.
My excuse for not entering is I consider it cost-prohibitive, I have a limited budget for such things and would rather spend my limited budget on new peptides, etc.

Is Matt Kaberlein too afraid to enter the Rejuvenation Olympics or maybe he didn’t make the top 100? He certainly has the money to enter, but I am sure he feels he is above a little friendly competition. After all, he has a Ph.D. Not anybody I would like to share a drink with. I think Bryan Johnson looks to be a much more fun guy.
https://www.rejuvenationolympics.com/dunedin-pace

[ng0rge]

@desertshores

I am sure he feels he is above a little friendly competition. After all, he has a Ph.D. Not anybody I would like to share a drink with. I think Bryan Johnson looks to be a much more fun guy.

I just watched the Mark Hyman interview with Bryan Johnson that @RapAdmin posted on another thread. I also just watched the latest Kaeberlein Optispan podcast. I think it’s unfair to imply that anyone with a PHD would be elitist/snooty and no fun to have a drink with. They both seem relaxed and personable to talk to. Johnson is more regimented and out of touch with the average person’s everyday schedule (as they talked about) - no eating after 11AM, everyday focused around getting a perfect sleep score? I don’t think I’d want to hang out with him…and he doesn’t drink, so that’s out. Kaerberlein, I think is more normal. Maybe he wouldn’t do well in the Rejuvenation Olympics but he actually spends his time working and researching, and not, like Johnson, being militant about every little health detail. I don’t know who’s more fun, maybe neither of them, but my guess is that Kaeberlein is more normal. (and he might have a drink with you…if you tell him that you’re on rapamycin.)

Edit: Look at us…picking apart our celebrities’ personal lives…maybe we should start a gossip thread.

[DeStrider]

I like both Bryan and Matt. Matt is doing research and spreading the news about longevity and Rapamycin. Bryan is just showing us that it’s possible to live past 122. Both have the potential to change the world and I would love to be having lunch with them both!

[Joseph_Lavelle]

@desertshores

Not anybody I would like to share a drink with

I have an entirely different perspective on Kaeberlein. He seems like a regular guy to me. Lifts weights. Throws a football with his son. Loves dogs. Looks like a regular Joe who is perhaps a little too obsessed with low body fat but that may actually be the most important longevity lever. I admire his mental fortitude in resisting the propaganda onslaught for longevity chemicals.

More than anyone else, he has had a big impact on my willingness to try rapa as well as my caution about not hurting myself with too many chemicals.

I’d have a beer with him in a heartbeat.

[Sasa_Loncar]

Can you find some data on that claim? I am using Taurine/Gly/NAC together.

[Sasa_Loncar]

@Deborah_Hall

I had read that Taurine and Glycine can cancel each other out

Do you have referral to that data? I am taking those together …

[DeStrider]

They don’t cancel out. The Glycine blocks the Taurine from being absorbed. So you’re wasting the taurine.

In addition to glycine, at least two other endogenous amino acids activate glycine receptors, β-alanine and taurine. Both agonists can bind to either glycine or GABAA receptors to increase membrane chloride conductance (Krishtal et al.

β-Alanine and taurine as endogenous agonists at glycine receptors in rat...

[Sasa_Loncar]

Any data on time between taking Taurine and Glycine/NAC?

[DeStrider]

I believe that 4 hours is enough time for the receptors to clear, but that’s my WAG.

I found a citation that the terminal half life of glycine is between 30 minutes and several hours.

[vamin]

That study is about receptors in the brain, it has nothing to do with absorption.