Jay
#267
Goran, How long have you been taking IP-6 Inositol and how long before you noticed improvements? Thanks.
Goran
#268
1gram in the morning and 1 gram before bed. Took me around 2 weeks to feel better. I still have a swollen prostate, so it is not shrunk or anything. But it is not agitated anymore when I drink coffee or eat spicy food. And I wake up once a night to pee instead of 4.
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zazim
#269
I am certainly saddened by Dr. B’s stroke and cancer diagnosis, but it doesn’t factor into my decision on whether I should take rapamycin. It does provide a cautionary note, however. This is unexplored territory. I have always taken 6 to 8 mg and never with GFJ. I am currently in week 3 of a 6 week break from rapa (my first).
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Nothing here to do with Blagosklonny - just saw this cancer information and thought it was interesting:
Paper:
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One of the best ways to avoid colorectal cancer is to get a colonoscopy. It saved me from getting cancer.
It doesn’t sound appealing, but they can put you under (or not) during the procedure. I stayed awake for mine, and it was completely painless (although it can be a bit uncomfortable if you stay awake). I have had 3 so far and they were covered by insurance. I am glad they found and removed the pre-cancerous polyps I had!
It took the first two to find all of the pre-cancerous polyps. The third time they found an adenoma. The stages: adenoma → pre-cancerous → cancer. It takes about 20 years to go from adenoma to cancer, but sometimes they can miss some polyps like they did with me. That’s why it took 2 colonoscopies to get them all (hopefully).
The alternative for me was cancer, which I don’t want to think about. I’m glad I made the right decision.
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Yes, early detection and treatment of cancer is the key. Colon, breast, skin and prostate cancers are easy to detect and then treat before they become a serious threat.
My grandfather died from his prostate cancer because it metastasized before it was detected.
My father detected it early and had it removed and is alive, healthy and going to the gym daily at the same age when my grandfather died.
Cancer detection is important and will save your life. Don’t be afraid and don’t put it off!
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LaraPo
#275
It probably makes sense to have Galleri test done from time to time. It’s not covered by most insurances and costs $949. It covers most cancers, but won’t detect brain cancer bc it doesn’t shed DNA.
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Colonoscopy is good----- but maybe not as good as we thought. In fact maybe no better than the yearly stool test FIT second generation or cologuard.
In gold-standard trial, colonoscopy fails to cut rate of cancer deaths - STAT (statnews.com)
There was also a recent study saying that we’ve underestimated the risks of perforation and bleeding. I’m big on colonoscopies but I’m glad that we’re perfecting imaging and plasma biopsies along with stool exams.
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Unfortunately, the study you cited seems to be inherently flawed. The RCT was comparing people who were invited to perform a colonoscopy with people who were not invited. A minority of patients who were invited had a colonoscopy done.
When the investigators compared just the 42% of participants in the invited group who actually showed up for a colonoscopy to the control group, they saw about a 30% reduction in colon cancer risk and a 50% reduction in colon cancer death.
So, the study is quite misleading until you dig into it. Also, patients in the uninvited category may have gotten a colonoscopy anyways.
It’s like having a Rapamycin study where I invite people to take Rapamycin but then the majority of those invited don’t take Rapamycin. But then I include their results in the Rapamycin group even though they didn’t even take any just because I invited them to!
For me, it did take two colonoscopies for them to find all the precancerous polyps. So I am assuming that the individuals in this study only had one which may not have caught everything.
The problem with the fecal blood cancer tests is that they screen for blood which means you probably already have cancer. I am more interested in preventing the cancer from occurring in the first place. I don’t want to treat cancer when I can prevent it.
My third colonoscopy, the doctor did puncture my intestine when he was removing a polyp and there was bleeding. He clipped it though and it healed. I have not experienced any problems since.
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Yes. Your critique of the study is valid. Definitely flawed, as are most studies, but we really expected outstanding mortality data even from a flawed study. I think follow up time is a problem. Maybe out to 15 years would’ve been better.
It doesn’t require cancer to show up on stool tests. Polyps, adenomas, etc will show up , as will diverticula’s disease and hemorrhoids. Again, not perfect.
The value of colonoscopy might depend on the skill of the provider. It can miss upper right sided lesions for instance.
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I stand corrected, Cologuard can detect pre-cancerous type 2 adenomas. However it has a lower accuracy rate and also reports false positives. I think if you go this route you have to have a lot more of these tests done than colonoscopies, but they are a lot less troublesome and a lot cheaper.
I am glad I did my colonoscopies because without them, I was on track for colon cancer in my early 60s or late 50s.
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José
#281
FWIW
A virtual colonoscopy;
And if you would like more paper see;
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I prefer a multiparametric mri scan due to the absence of radiation , especially c/ w a CT scan. But it’s worth doing either if you have a strong FH of colon cancer. This is particularly true if you’re nervous about getting a colonoscopy.
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For the most part it’s a great screening test, but even with you it took two tests and you suffered a perforation. Still worth it to detect precancerous lesions. Especially since they were able to remove them at the same time as the test. That’s a big plus.
1 Like
José
#284
Would you know who preforms multiparametric mri scan for the colan, looking for cancer?
They do multiparametric mri scans for prostate.
There’s two of them but I prefer Prenuvo because of its multiple locations. It won’t look at just one area of the body and is fairly expensive. Doctors don’t endorse it because they say it’s actually too sensitive and will lead to unnecessary procedures. That wasn’t my experience. They told me flat out that the couple of small things were very likely benign. This will be even more clear on subsequent exams.
The other thing, if you just want to look at the prostate would be the very good PET scan.
You could also get an MRI with contrast, but I don’t trust gadolinium.
It told me that I had some small diverticulosis but no evidence of colon polyps or cancer.
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José
#286
I would pay for a Prenuvo scan, this would produce real tangible concrete value, more than a $2.500 online course.
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