#409

I think the issue is a combination of dosing and timing of dosing. For the optimal results you need the trough to last quite a while.

4 Likes
#410

If he hadn’t taken rapamycin, he might have died long ago. Lung cancer can be seen at an early age. It is not only seen in older people who smoke. There are many lung cancer subtypes: adenocarcinoma, squamous cell carcinoma, small cell carcinoma, etc.

2 Likes
#411

I think you raise an interesting point about dosing and timing. To extend the trough duration of rapamycin, has anyone considered splitting the dosage throughout the day? For example, instead of taking a single large dose, one could take 2 mg at the start of the day, then another 2 mg every two hours until reaching the target dose. This approach might help to extend the trough period and potentially optimize the effects. This is just a hypothesis, but I’d love to hear if anyone has tried something similar or has thoughts on this method.

3 Likes
#412

I used to take the full dose, then 8 hours later take another couple to boost it back up to the max. I figured with a 2 week gap the 8 hours was really nothing and it increased the AUC by almost double, and at low cost.

5 Likes
#413

My own view is that peak concentration is important.

1 Like
#414

My own approach to dosage is as follows:

Sunday morning in fasted state. Take 8mg Rapa with 1/2 tin of sardines.

Four hours later take another 8mg Rapa with the other half of the sardines. Fast the rest of the day.

Monday morning take 1000 mg Quercitin and 50g Dasatinib with 1/2 an avocado. 1 hour later eat the other 1/2 avocado with another 50 mg Dasatinib and another 1000 mg Quercitin.

Monday late afternoon eat a moderate meal of chicken, broccoli, and carrots with 500 mg Metformin ER.

Tuesday morning. Continued D + Q, but resume my normal life of eating everything in sight and weight training.

I only do the D + Q thing every other month, but I do fast and restrict calories whenever I have taken Rapamycin.

To get back on topic. I think Dr. Blogosklony is still advocating fairly high doses of Rapamycin at two week intervals, and John Hemming is also advocating a high peak level of short duration. Both of these men know more than I do.

From what I have read, Rapamycin in animal studies is usually in the animal’s food, so dosage interval is the least understood aspect of Rapamycin usage.

Leucine is the big signal for our bodies to elevate mtor, and Rapa blocks this signal. I am restricting calories and leucine after taking Rapamycin, but perhaps this makes no difference since Rapamycin blocks this signal anyway.

Whatever Dr. Blogosklony is doing must have some value since he is still here and fighting on. I wish him well.

4 Likes
#415

After rapamycin, not consuming anything but water that day will maximize autophagy and probably trigger new stem cell formation, a good strategy. So what is the effect of taking D+Q as a senolytic on you, have you experienced any side effects?

#416

I get a mild headache. It feels like a slight alcohol hangover. I do not know if that is from the quercitin or the Dasatinib. I only get a few pimples from the Rapamycin.

#417

Yes, and a lower dose might have continued to keep it a bay. He possibly (who knows for sure - as Matt Kaeberlein correctly bemoans, no real research re optimal dosage for overall health) got up to a level of immunosupression where there was more harm than good from taking rapa. The does makes the poison etc.

4 Likes
#418

Have tried to warn people on this site that I have monitored my rapamycin use for over four years.

And, in that time… the only negative spike in my health was 2 years in…when I upped my dosage to about 38 mg every 8-10 day. My rational for 7 months higher use was due to Mikhail Blagosklonny statements that more was better.

From my negative reaction… yes an N=1, he was wrong. My biological tests showed I was aging faster in both my inflammation and methylation.

Once I reduced my dosage to 6mg weekly for 8 months… everything stabilized and the good benefits came back. His over zealous rapa use might have hastened his death.

My humble opinion.

8 Likes
#419

What I would say is that inhibiting mTOR holds back the immune system. The immune system has an ability to fight cancer. Hence if it is turned too low all the time then it could act to permit cancer to survive moreso.

My approach is to have a large dose, but quite infrequently. That means that for a material part of the time mTOR is not inhibited and the immune system functions as normal.

Hence I think you could be right.

5 Likes
#420

38 mg is definitely too much. At that level you’re at risk of shutting MTOR2 down and facing MTOR rebound. I think if you are weekly dosing you should keep it below 20 mg. However we know that 3 mg or less weekly is too weak. Personally, for me, 14 mg seems to be my sweet spot. Above that I develop hives.

4 Likes
#421

I’m pretty sure… finally … my sweet spot is 6 mg one week eight 8 mg the next… alternating between 6 and 8 every other week once a week.

I tried doing 4 mg once a week for about five months and it was too low. At 4 mg once a week I started regaining arthritis and my skin or my knuckles and elbows started to dry out.

For me the little arthritis pain, and skin quality change was a definite clue that the rapamycin was not working as good as it had been.

When I went back up to the 6-8 mg dosage - after a month skin on knuckles and elbows was back to soft and normal.

7 Likes
#422

Since 6-8 got you back to seeing a benefit, did you try 9-10 to see if you got more of a benefit?

However you are using noticeable signs to find your ideal dose. Great job!

For me, hives are a noticeable sign. I wonder if I should push my dose to the borderline of getting hives or just past it.

1 Like
#423

To be fair to Dr Blagosklonny, I believe what he said was to use as high a dose as you could without side effects. You were experiencing edema in your ankles, I recall you saying. Plus you said test results were negative as well.

It’s a risk we all have to fight off…the tendency to rationalize that more is better. How many supplements do we take, and how much? But with pharmaceuticals, the risk is magnified.

I occasionally will take an extra 1mg of rapa just because…and then I feel like shit for a few days. Stupid.

4 Likes
#424

Rapamycin, like all drugs, is a double-edged sword. The correct dosage is very important. This also varies from person to person. It is important not to deviate too much from the average doses. For some, 6mg is best, while for others it can be 2mg or 3mg.

5 Likes
#425

It remains hard to make these judgments. I have the detailed measurements from my second high dose. The third is now fading and I have the CGM pointing towards a reducing glucose baseline as happened with the second.

I am inclined not to increase the dosing from the current 22mg plus GFJ. It causes the expected sleep disruption and usual effects of mTOR inhibiition (reduction in WBC, increase in glucose, hepatic insulin resistance). I think, however, it is also creating systemic improvment in Mitochondrial Membrane Potential.

I am, however, back on weekly blood tests at the moment.

7 Likes
#426

Hi John,

As probably the most blood tested man in Britain, would you be kind enough to recommend a decent blood testing service? I am struggling for example to find anywhere that offers an Omega 3 level test unless it’s bundled with a full health check which I don’t need right now. Unfortunately I don’t get on with home testing kits supplied with lancets. I am based in York but obviously happy to travel as necessary. TIA for any guidance you can offer.

1 Like
#427

True Joseph – Blagosklonny did state in several places to go as high as you could without side effects and I certainly was having what I considered several silent pathology side effects. But when you consider that the typical dose is between 6 & 8 mgs a week standard set in part from Joan Mannick’s immunity studies. It would seem higher doses would be higher than that.

And that’s where I got into problems, so it was as if he was encouraging a much higher then 6-8 mg.

We’re all responsible for our experimentations and any consequences. I’m just trying to point out to those on here…that from my testing every six months for four years, I can see that more rapamycin in my system is not better.

4 Likes
#428

I wonder if Dr. B tried the combination of Ivermectin + Febendazole that has been used successfully as part of a protocol by Dr. Makis from Canada. Also recommended by FLCCC I believe. Anyone have any experience using that drug combination as a cancer treatment?

1 Like