Dr. Blagosklonny's Cancer

[John_Hemming]

Oddly enough i had this test done recently by onedaytests for which i have a discount code. I dont however have the results as they take more than one day. (Over a week)

[mondagai]

Random thought; so is regular/close monitoring of blood sugars and cholesterol for large and unexplained drops a good method for identifying cancer in the absence of symptoms?

[essexaid]

Thank you John, that’s really helpful.

[Danlalane]

Hey @Agetron, like you I have been playing with my dose. I dropped down to 4mg every other week (w/ GFJ) and it is absolutely too low. I seem to have lost all the benefits. Are you still GFJ with your 6mg and 8mg so your absolute doses are 4-5x?

[John_Hemming]

I can get them to email you a discount code (which also gives me a discount), but I need your email address. If you put that in a PM I will do this.

They are not the cheapest, but they do quite a good job.

[Agetron]

Hey Dan… I am strictly taking the rapamycin with no grapefruit juice GFJ. At this time.

I may start back on grapefruit juice GFJ in December just to conserve my stock of pills.

Especially as rapamycin seems to be becoming more and more popular in mass media, I’d like to have at least a 4-year supply available.

It was very apparent to me through skin changes … drier… rougher… my energy was a little lower… even memory slowing down a bit at a 4 mg rapamycin dose for about four months.

I’ve been on my 6 mg one week and 8 mg the next week for a while now… Skin on knuckles and elbows has rebounded back to its normal softness… energy is there and memory is there again.

As a note, my doctor says two things that make him aware that rapamycin is working on improving my skin is the tautness of my tummy - no extra or looseness in that skin area and same with the elbows and knees. None of the typical old wrinkly knee and elbows of a person my age - almost 67 years.

[Sasa_Loncar]

Do you know if those drugs are made only for animals or there are some same meds made for humans? Can you link the protocol and some more data on them?

[blsm]

Agree, at 100 pounds I find 4-6 mg is too much for me personally.

[aaa21usa]

There is lots of good information on the use of Ivermectin + Febendazole/Mebendazole on Substack. Check out the blog posts by Dr. William Makis, and “2nd Smartest Guy in the World”. Dr. Makis publishes many case studies of patients who have treated themselves with these anti-cancer drugs.

[RapAdmin]

Just keep in mind that case studies are at the very bottom of the scientific evidence hierarchy:

[Joseph_Lavelle]

Thanks. I’ve saved these.

These charts are magnificent but they still don’t include the additional variable (more complication) of who / what was studied (worst to best: worms, inbred mice, wild type mice, primates living in cages, people not living in cages, people like me, me) for establishing a reason to have faith (word chosen carefully) in the results.

There is also the variability in the “quality” of the scientist / journal. A well done double blinded study is worth more than a cherry picked or poorly screened meta analysis.

That said, the thing I like best about meta analyses is the clarity in seeing that the raw data is all over the place …telling me there isn’t a clear signal so the benefit is probably not there for me. The signal is almost never a no-brainer.

The main lesson I’ve learned over the last few years is these scientific studies are not designed for me to use in making decisions about what supplements or drugs to use to optimize my longevity. At worst they are design to get me to buy something, and at best they add to the body of knowledge upon which future work can build toward an eventual understanding of how the body works and ages (breaks down slowly) and can be aided.

We are too far from perfect knowledge to wait so how to decide when it’s good enough? How to prioritize based on personal need vs quality of knowledge about mechanism and intervention effects? How to avoid wrecking everything by being too aggressive (too much or too invasive) or cheap (poor quality stuff) or lazy (focusing on pills)?

This is the struggle.

There is nothing more dangerous than to leap a chasm in two jumps.

[JKPrime]

I’m 150 pounds and find 10 mg weekly does barely noticeable. There are no side effects to speak of, Perhaps how well a person can tolerate rapa has something to do with individual differences and for how long a person has been taking it?

[Agetron]

Sounds good…

But…yeah… I felt fine the 7 months I went high. Biological test at the end of that cycle said a different story.

Matt Kaeberlein says it can be silent pathology. It took almost 8 months to get back to good biological markers at lower dose of 6 mg.

My N=1.

My advice… check your inflammation numbers and methylation DNA. I just ran both tests… GlycanAge and TruMe.

[blsm]

That makes sense to me. I feel like I’ve tolerated it differently at various times over the last 2 years. I might revisit 4mg on my next dose and see how it goes

[Joseph_Lavelle]

@Agetron

methylation DNA

What gives you confidence that this means much or anything reliable? Didn’t Karberlein do multiple versions of these tests on himself with results that say…not ready for prime time? I have never done one so I don’t have any personal experience but I’m reluctant to waste money or get bad data into my head to distract me.

[Curious]

I agree, we need the raw data from RCTs and meta-studies. But we also need individualization.

We need to separate, population-focused medicine that provides us with medications with an acceptable, well-known risk-reward profile. A rigorous system based on large studies that provides us with a probable positive outcome when it comes to giving a medication to specific disease populations.

Since we are all pretty unique when it comes to our biology, we need to separate this medical system of standardized mass medication from personalized medicine, which focuses on precision medicine tailored for genetic uniqueness and the individual lifestyle of the person. This is how many doctors want to work and try to do, but of course there are obstacles when it comes to how the current systems in the world are constructed; there are also obstacles when it comes to resources and scientific knowledge.

I think this is what many of us here try to do when it comes to supplements and medications, based on our individual reactions and situations in life, we aim at tailoring and optimizing our biology and treatment outcomes using an iterative approach, searching and learning what works as we go. Trying to tailor our self-treatments to individual genetic profiles, previous experiences and using regular testing will significantly improve the likelihood of optimal health.

This personalized medicine/hacking is a kind of N-of-1 trials that provides direct evidence of treatment effectiveness for me as a specific patient; this is unlike the traditional randomized controlled trials (RCTs) that yield population-level data where the expected outcome is for a population and not for me. I just have to pray that I fit into the population average when it comes to the responses I get. An individual focus allows for treatments to be tailored specifically to what works best for that patient (me).

As a patient or a health optimizer, personalization will improve the effectiveness of interventions/treatments. By using genetic profile or regular testing and continuously assessing how the patient or biohacker (I or Brian Johnson) responds to different interventions over time, the system of personalization and N-of-1 (trials and errors) can improve treatment efficacy and reduce adverse effects. This personalized approach ensures that therapies and interventions are more likely to be effective for the individual (me).

[DeStrider]

@Joseph_Lavelle My father and I both had bad results from epigenetic tests. We were both over a decade older than our chronological ages. However our Levine tests pointed us out as being a decade younger! These tests are not ready for prime time and are not useful for predicting which interventions you should try.

Although taking Rapamycin did reduce my epigenetic age by 7 years on my second test.

[Agetron]

Hey Joseph - I certainly can empathize with the stance that what can biological test provide.

Although Matt Kaeberlein has his doubts on epigenetic testing. I am focusing on two areas of testing that seem to be pretty good and not a shotgun approach to here is your biological age. I focus on inflammation which can be understood from your glycan assessment. The number one authority on this is Gordon Lauc. So this test shows me where I am at with inflammation. Rapamycin should reduce your inflammation well below your average normal levels for your age. Was used as a baseline and post test for PEARL trial. That is a pretty high bar to get used. Been Glycan testing and monitoring for 3.5 years.

The other area that can show aging is Methylation DNA. Respected anti-aging specialist Dr. Yelena Budoskaya who work with tick virus testing and more shows she is no charlatan in the science field. She does one thing and well once again. For me using two test consistently I think keeps me on track for all my anti-aging work. Testing as I try new things. You might think these companies will tell you whatever you want to hear. Not so, both GlycanAge and TruMe say my biological age results are atypical - I am a fraction of a fraction for my age based on my many tests which are consistent (others like me simply do not exist. This directly from Dr. Budovskaya and Dr. Lauc’s team) . It has to be the rapamycin.

If you want more on why I pick these tests - mainly due to the caliber of the leadership and these company’s respect in the aging field.

Glycobiology simplified: diverse roles of glycan recognition in inflammation

Glycobiology simplified: diverse roles of glycan recognition in inflammation

Understanding glycans and chronic inflammation is the main feature of many long-term inflammatory diseases such as autoimmune diseases, metabolic disorders, and cancer.

Link: N-Glycosylation and Inflammation; the Not-So-Sweet Relation - PMC

The company GlycanAge under the direction of Dr. Gordan Lauc has developed lab work looking at blood that measures your glycan structures and can accurately identify your level of inflammation.

December of 2022

GlycanAge with the AgelessRX – PEARL study. Dr. Sajad Zalzala and Gordan Lauc from GlycanAge

March 23, 2022 Link: https://www.youtube.com/watch?app=desktop&v=GYxqJVg15NM

Tahoedenizen - Daniel Fylstra

I am newly enrolled in the PEARL study (PEARL Trial to Prolong Life With Longevity Products | AgelessRx 1, Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study - Full Text View - ClinicalTrials.gov 1); I was admitted shortly before they stopped enrolling new participants. I talked with “Dr. Z” (Sajad Zalzala) on Zoom, and also in person at RAADFest in October. I’ve completed the informed consent, initial blood tests, DXA scan, GlycanAge and Thorne Microbiome tests, and as of this date I’ve taken two weekly doses and completed two weekly reports (blood pressure and some health questions).

I haven’t yet received results from the GlycanAge test. I have had a series of epigenetic age tests, because I previously participated as a subject in the TRIIM-X clinical trial (http://interveneimmune.com/, Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial - Full Text View - ClinicalTrials.gov). I have learned to view the epigenetic age measures as relative measures, and not to take too seriously the reported “age” as a comparison to chronological age. (I have seen a 28-year range in epigenetic “age” measures computed from a single methylation dataset, using the same blood sample – with PhenoAge the lowest and GrimAge the highest.) So I’d say you have a signal to reduce your Rapamycin dose, but I wouldn’t interpret this as a “real” 15 chronological year change.

The Company TruMe developed by Stanford Anti-aging specialist Dr. Yelena Budovskaya.

Interview of Dr. Budovskaya with respected anti-aging Dr. Robert Lufkin MD – rapamycin expert. I was one of the off label users who’s blood was tested by Dr. Lufkin. After my blood work was done I received a voucher for Amazon – nice. Supplement money.

Link: https://www.youtube.com/watch?v=L42i_1Y78WA

Kristers interview of Dr. Lufkin 2024

Link: Rapamycin Update - Robert Lufkin MD

Link: https://trumelabs.com/about/?srsltid=AfmBOood9lJ7QIcee-JzW4bcrHl2Fxe87Zl-ppzcydq0k3wyl98lNiwy

Supported by AgelessRX

Link: Methylation Test Kit - TruMe Methylation Saliva Test | AgelessRx

[Joseph_Lavelle]

@Agetron Thanks. I’ll have to digest this elephant for a bit.

[Agetron]

Sorry - not sorry! Hahaha.

It was in one of my first podcasts in understanding the aging process – before I even started rapamycin (I did use this podcast’s information to encourage my GP - physician to prescribe rapamycin off-label)… Dr. Attia and Matt Kaeberlein’s The Drive podcast #175 September 13, 2021 “The Biology of aging…” Particularly what I learned about inflammation (inflammaging the new term) that had me zero in on that biological marker for testing the benefits of rapamycin. Hence, my use of GlycanAge - the best in measuring your inflammation response.

• The role of inflammation in functional declines and diseases of aging [50:45];
  Link: https://www.youtube.com/watch?v=_vsNw-OCciU

Sterile inflammation with aging - . Rapamycin tamps down on that chronic sterile inflammation - the inapropriate activation of the immune system.

Dr. Kaeberline: “If you’d of asked me 15 years ago about the role of inflammation in aging… I wasn’t bullish on inflammaging at that point… and I have become very bullish on inflammaging as critically important for many of the functional declines.and diseases of aging that we see in people.”

Hopefully you will see how I came up with this as the marker I would test.
And here I am with an inflammation level of someone 45 years old - not almost 67 years old. And, even the GlycanAge company says… my repeated tests are consistently low and not typical at all. Of all the clients that tests - there are none - my age with my biological discrepancy of 21 years!

The inflammation spike was when I was dosing high with only a week between dosing , I was knocking my MTOR1 real low if not completely off - so to say. When I reduced my dose the inflammation benefits return. I have asked @tahoedenizen to chime in!