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Awesome - thanks for putting this up. I love watching Dr. Green and gaining from his experience. I’d not have been aware of this without you posting.

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FWIW

In my view skip the first 18 minutes {you will extend 18 minutes of your life, time is your most valuable asset and the first 18 minutes is a wast of your time]

Dr Green monologue starts at 18:00

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Thanks so much, there are so many videos here and they take up so much time.
And remember that you can increase the speed slightly and still understand them.

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The 5th one is very interesting, where AG argues that rapa (tamping down Mtor) protects you from inflammation-related diseases so you have a chance to grow into old age, but by itself doesn’t extend longevity, except as a side effect of tamping down disease. But eventually the mitochondria don’t generate enough ATP and you die because of it, and that we need is a breakthrough to solve this problem (simplified version from a non-biologist). I’m waiting for the biologists to discuss this, but maybe I’m just naive and this all along has been the common understanding of the situation.

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The headline: None! Not a single one of Dr. Greens Rapamycin treated patients have died from a sudden acute cardiac event over the entire course of his rapamycin practice (6 years). Statistically, some of them should have.

The nitty-gritty: I would have liked to see annualized patient totals added together rather than last year’s total used for his ā€œpatient-yearsā€ calculation. I was confused by the ā€œdeath certificateā€ cause of death discussion vs a more clinical definition of an acute cardiac event. I’d like to know if Dr. Greens’ patient population have had any known deaths.

How about that headline though?

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We may find that aging really is an accumulation of disease-like states. Nobody ever died of good health!

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Damage kills most people before 100 but no one has ever surpassed the age of 122, not even by random chance alone despite there being over 8 billion people around nowadays. There must be some programmed factor that eventually kills us even if we avoid all kinds of damage.

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My maternal great grandmother lived until 104, more than 100 years ago; my mom is currently age 99 years; my dad lived until age 97-- none of my relatives ever exercised- ever. They drank little-no alcohol. Incessantly, my mother and father and other elderly uncles an aunts smoked tobacco cigarettes. My dad was not well, but had surgical treatments which were successful. Daily for more than 40 years
my mom has suffered from unrelenting COPD, its various comorbidities and continual aging and lives miserably; but she’s alive. My Dad passed in 2016 from a hospital nurse’s incompetence. My mom is alive and why/how? I was tested by my friend Chris Talley, bionutritionist extraordinaire-- Chris Talley…Google Chris— he and Genova Labs told me i have an exceedingly high Cadmium toxicity; probably due to second-hand smoke since in utero because my mother smoked 4-4 packs of cigarettes daily during pre-natal, in utero and and postpartum. My twin was still born; I was delivered Frank breech; I was asphyxiated during birthing; I’m a three-time Cancer disease survivor; Im not a common cancer gene carrier. Ive exercised and been athletiv since 7th grade. Ive practiced Yoga etc. and eaten seriously healthfully since age 30 yrs. I’m post mensupaysal since age 50 yrs. I’m now age 74 years. Dr Green prescribed his typical rapa dose which Ive taken adherently for more than 10 months with no standard side effects. I listen to Peter A. and MATT K. Etc. Everyday. I go to planet fitness and use their Hydromassage chair for 30 minutes and get blood circulation therapy. I drink no alcohol nor smoke-- never, ever. I drink Kate Farm Renal medical food protein every other day. Blah blah blah. BTW: There’s a Death-prediction App that I found on line and its calculated my death for 10 years from today. I read this Rapamycin groups’ various comments and articles and you’re all so incredibly smart, intelligent, intellectual, educated and articulate…so thank you, all. I’m not sure why I wrote the above. I wish everyone well and will keep reading your posts and Pubmed articles, etc.–until I die. With love, Jan Stein

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That’s a very inspiring story, thank you! Yes, unfortunately, a lot is down to the genes, luck of the draw. Many of the very old, centenarians and near centenarians have pretty poor lifestyle habits, and while perhaps it doesn’t affect their lifespan I’ve got to think it does affect their healthspan, especially the more extreme cases. Meanwhile dedicated healthy living people pass early or are struck by disease.

Still, the stats are what they are and rationally we must follow best practices to maximize our genetic potential, whatever it may be. We really have no choice. After all nobody is going to recommend smoking or sitting on the couch a lot, just because a lot of centenarians seem not terribly affected. Just because they can, doesn’t mean you can.

Sometimes when I see what people eat, how much alcohol they drink, I remark to my wife that if I did that, I’d be dead within a year. Meanwhile folks like Dick Van Dyke can be massive alcoholics for years, clean up, and keep on ticking in good shape into their 90’s. Go figure. We’re all dealt different cards in life and must do the best we can with them.

Thank you again, and welcome!

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Thank-you for reading my ā€˜blah blah blah’ and for your thoughtful comments. All the best for 2025 and beyond, Jan Stein

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