Tom34
#21
in Salmont DNA there is not a good ratio into cytosine. And mostly purine unfortunately. Also, you not sure the quality at all sorry
What do you argue the ratios are:
a) In Salmon DNA
b) Expected in the cell in terms of dNTPs.
Tom34
#23
a/ you get about 30% dT, 20% dC, others are purines… As you may imagine I already contacted thoses japaneses manufacturer companies much prior this post since our last discussion 
b/ The only one you want are dT and dC, ratio tested in the TD2 study is 1/1 but the ideal ratio is slightly more dC than dT like 55/45 because dT can be an issue as well in the cycle.
So salmon DNA is not what we may want as an ideal unfortunately. Still the only other option is to produce thoses dC dT in a GMP factory…
Btw, what is your personal opinion about desoxy purines ?
Also, im not that strict on ribonucleotides from yeast, they still give mice and people good result for aging. Its just another theorical mecanism
Jay
#24
I asked ChatGPT this question:
“Check for any publicly available clinical trials (in the U.S. or internationally) that have tested salmon-milt / DNA-based supplements (or marine-DNA supplements) for health outcomes (e.g. skin health, aging, cellular markers). Include only high quality trials with adequate subjects.”
The answer was long. So, I will not post it, but you can go to chatGPT and ask the question if you want the complete answer.
My summary of the answer to the question is that salmon milt has shown benefits in both injection and topical use, but there’s not much evidence for oral use.
The point about a), however, is that there are four bases and if they are all equal then you would have 25% of each.
One set of cytosolic test results in fibroblasts had T 40%, A and C 25% and G 10%. However, it is C that goes wrong the most followed by G. Hence we are not doing that badly with salmon milt which is quite similar to brewers yeast.
Btw, what is your personal opinion about desoxy purines ?
I am not quite sure what you mean by this. Obviously you don’t want the concentration in the cytosol to be too high for purines or pyrmidines.
Bicep
#26
This is a little over a buck a day:
https://www.amazon.com/ACTIF-Mega-Support-Advanced-Factors/dp/B0DJCLT27T
But to me it seems like a long shot.
JuanDaw
#27
If concerned about gout, one can take oyster mushrooms, because it has high anti-gout xanthine oxidase (XOD) inhibitory activity.
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It only has 10mg of DNA in each capsule, you’d be taking about a full bottle a day (so, 40$+ per day)
Remember:
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Current Market Reality: Most commercial Salmon DNA supplements contain 100mg - 300mg per capsule. A therapeutic “biohack” dose likely requires 4-6 capsules daily or bulk powder usage to hit the ~1.1g target.
It doesn’t provide enough information to make good judgments.
Just to inform people. I stopped taking 25g a day of Brewers Yeast extract (deactivated) really to see what happened and my urate level went back below 300 (micromoles per litre) (to 290.6). Last week it was over 400, but that was unsually high with the BY, it was normally around 360. Looking at when I stopped it for two days betore the test it probably clears in a day or two. Obviously if there are any urate crystals anywhere (which I have no symptoms of) those would take longer to clear.
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