#103

Some ROR are around 4x here: Experience with GLP-1s - #94 by adssx

Again, nothing is proven, these are association studies. But if true that would be massive.

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#104

I am not good at interpreting the results.
What do you think is the probable actual risk based on these studies, 1 in 10,1 in 100, etc?

#105

It’s a relative risk compared to non-use. So IF this is confirmed and causal, then it means that using drug Z would increase your risk of suicidal ideation by 4x. So, if you’ve never thought about this in your life, it will probably not change anything for you. If you have suicidal ideation once per year, then you might have it once per quarter. (I’m oversimplifying.)

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#106

RHR/HRV changes might be related to direct action of GLP-1 in the heart: Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node | Cardiovascular Research | Oxford Academic

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#107

Is this action detrimental or not in non diabetic / non overweight individuals?

Interesting bit:

In anaesthetized pigs, neither cervical vagotomy, adrenergic blockers (alpha, beta, or combined alpha-beta blockade), ganglionic blockade (hexamethonium), nor inhibition of hyperpolarization-activated cyclic nucleotide–gated (HCN) channels (ivabradine) abolished the marked chronotropic effect of GLP-1.

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#108

“It is tempting to speculate that treatment of GLP-1 RAs might be combined with drugs targeting calcium clock dynamics or intracellular calcium levels, such as calcium channel blockers, or other downstream effectors, to prevent heart rate increases in patients receiving GLP-1 RAs where this may be considered beneficial.”

So, diltiazem might be the best choice (perhaps at a low dose) to reverse the elevated heart rate without affecting weight loss.

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#109

Still on GLP-1RAs and suicide: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase®) 2024

A mixed pattern of ROR emerged with respect to suicidality and select GLP-1 RAs
RORs for suicide ideation increased for semaglutide, liraglutide, and tirzepatide
RORs for suicide attempts decreased for semaglutide, dulaglutide, and liraglutide
RORs for suicide completion decreased for semaglutide, dulaglutide, and liraglutide
We searched VigiBase reports from inception to January 2024. The RORs for suicidal ideation were significantly increased for semaglutide (5.82), liraglutide (4.03) and tirzepatide (2.25). For “depression/suicidal”, the ROR was significantly increased for semaglutide (14.74) and liraglutide (5.86); and for suicidal behaviour, the ROR was significantly increased for semaglutide (6.52) and liraglutide (3.90). However, for suicide attempts, the ROR was significantly decreased for semaglutide (0.11), dulaglutide (0.075), exenatide (0.047) and liraglutide (0.15). For completed suicide, the ROR was also significantly decreased for semaglutide (0.01), dulaglutide (0.003), exenatide (0.002) and liraglutide (0.008).

Very weird 14.74x risk of “depression/suicidal” but suicide attempts divided by 10 for semaglutide and completed suicide risk divided by 100?!

And here again, as in other papers I cited in my previous post, it seems that for the suicide risk: semaglutide > liraglutide > tirzepatide > exenatide = dulaglutide.

#110

Just started on compounded Semaglutide injections two weeks ago! Waiting a few more weeks to share my experiences with it here, but I’m impressed so far and the early side effects haven’t been too bad for me.

3 Likes
#111

compounded drugs legally allowed in some situations and may be much cheaper.

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#112

update please? Have you lost any lbs and how are your sides now?

#113

I have retatrutide and have been using it since May 2024.

I started on Tz weekly (max dose was 3.5mg) in August of 2023 when I weighed 190, over 9 months lost 35lbs and was pretty happy with that. Then May 2024 switched to Rt at 2.5mg and dropped another 15 lb over the next 5 months and now at 140, my HS grad weight.

Maintaining easily on 2.0mg weekly.

I also take another 7 peptides on a regular basis, some for over a year now.

I’ll be 69 in 2 months and never in my wildest dreams did I think I’d be able to achieve this in my lifetime.
Steve_M_fat_20170810
Steve_M_skinney_20241107

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#114

Currently at 10 mg a week every monday. I was 78kg, I’m 63kg now. Sides are manageable, I can eat but feel weak cause It’s still not enough
I tried 12.5mg and vomit with diarrhea. I’m going to lower to 5mg next week to stop weight loss.

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#115

wow great results. not to nickel and dime your message but the first pic can’t be when you were at 190lbs? I’m quite e few more lbs. than that and guaranteed I look way way way less fat than that. so there’s got to be some more explaining to do lol

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#116

I’m not tall :slight_smile: 5’ 6" to be precise.

I have been as heavy as 210 but that (2012) would have been before the fat pic (2017) where I was probably in the high 190’s

My 2023 weight before starting this journey was around 190 don’t have any “good” pics at that weight.

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#117

I see, thought you were closer to 6 feet…

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#118

LoL! not even close :slight_smile:

#119

I just took the skinny pic a few minutes ago in my office so it would be as current as possible.

My 20 minute x 3 day workouts are going well, weights are going up at a moderate pace and my time on the Proform HIIT machine is increasing with additional resistance. Yesterday I breezed through my setting and will be adding some time and resistance to that. I’ve always hated “aerobic” but yesterday it was like nothing. I’ve never experienced that in my life.

Through my 20’s and 30’ and into my 40’s I worked out as heavy as I could, did some aerobics and am pretty strong. My DNA test indicates I have the strength gene but not the size gene and that explained a lot about why i could out lift most of the bigger guys at the gym but never got “big” no matter what I did.

And yes, I’ve done more reading on this topic over the years than I can remember. And tried pretty much anything to get big other than PEDs.

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#121

A bit more on this if you don’t mind, and what are they good for? one paragraph explanation for each if possible, please.

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#122

There is a peptide/bio thread with most of it. I can outline my peptide adventures a bit later and may put that in my introduction thread with my other interventions.

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#123

Is it recommended to fast while on GLP-1’s or is that a big no. Asking because it seems easy because of appetite suppression, so might as well stay couple days without food also (unless not recommended for medical reasons)?

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