The major difference with Reta is the GCGR component;
Sema = GLP1-R
Tirz = GLP1-R + GIP
Reta = GLP1R + GIP + GCGR
All the G’s engage brown fat but 3 G’s seems to be more effective than 1 or 2. Engaging brown fat helps with thermogenisis.
The addition of the 3rd G - GCGR component in Reta is the reason you can eat a bit more and enjoy it, while losing more than the others.
I’m finding that I feel more “normal” with Reta. With Tz I found that the satiety part made me feel prematurely full and I was not enjoying my meals as much. I do like a nice steak or some prime rib but was not interested in it nor could I eat very much of it. Now I can eat and enjoy but still have full control and am maintaining my ideal weight of 140lbs with 2.0mg per week. Same for my wife but her maintenance dose is 2.5mg
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Davin8r
#145
I think it’s yet to be definitively determined what the contribution of reta’s relatively weak glucagon agonism vs its quite strong affinity for GIP to its weight loss effects. Peter Attia suspects it’s more the GIP, but time (and more research) will tell!
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adssx
#146
Do different GLP-1RAs have different effects on heart rate increase? I find that semaglutide 7 mg increases mine too much to my liking… So if tirzepatide, dulaglutide or retatrutide are better I could give them a try…
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I think that the individual response would need to be evaluated individually 
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7 mg? I take 0.25 mg once per week, and the effects are almost too much for me. Are you really taking 28 times that amount?
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good catch!
Sema utilizes very low dosing, I was not paying attention to that aspect
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Davin8r
#150
He’s taking Rybelsus (the oral version, only a tiny bit of which is actually absorbed). I think 7mg is bioequivalent to roughly 0.5mg SQ injection.
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adssx
#151
Yes but their half-life periods are so long that testing takes time… I’ll first try to increase my HRV and lower my heart rate with tVNS following your guide 
I’m using oral semaglutide: the daily pills, not the weekly injections. The dosage is different.
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Rob01
#152
I started taking Tirzepatide to help improve body comp along with other preventative health factors as I mention below and it’s been huge. I’m not overweight but just wanted to improve my muscle ratio and general health for health span and hopefully lifespan. I think it can help change the natural set point ratio of fat to lean body mass if one is doing the right things (lifting weights, protein). I started at 1 mg/week and over the course of 2-3 months moved up to 4 mg. The effects were initially very strong (very strong appetite suppression, bloating, fatigue) but over 2 weeks reduced at which point I would increase the dose a bit until I got up to ~4 mg/week which I think is good for me.
From what I’ve read the GLP1s appear to be dose dependent and I observe that through monitoring my FG. At higher doses FG goes down further. My current thought is that if one is looking for the benefits of reduced A1C, reduced inflammation, reduced neurological decline, CKD risk, heart disease risk, improved immunity, etc…this is prob all dose dependent. If one is micro-dosing (let’s say 1 mg TZ or even 2.5 mg or equivalent of other GLPs) then I think it’s very possible much of the benefits are reduced. That’s the reason I wanted to try and move up near the 5mg dose even though I didn’t need to.
Does that sound plausible??
For me personally, I’m 150 lbs and stayed at 150 lbs and just got more muscular/harder. It’s been kinda amazing like that; my wife asked if I was taking steroids. My starting FG was low to mid 90s and with 4 mg TZ it’s now at low 80s. Also I have to eat more since starting TZ or I just loose weight which is not my goal. At 4 mg I don’t really have much desire for food but can easily eat the meals I plan out. I have no desire to snack which has been great. I just eat the planned meals and that’s it.
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From 78 to 61 within 3.5 months I think
Currently at 5mg a week, with no side.
My weight is now stabilized. No longer hyperphagia, no longer food noise.
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adssx
#154
Impressive! These drugs are miracles.
That’s tirzepatide, right?
Did you notice an increase in heart rate? HRV? Any other impact on biomarkers (fasting glucose, insulin, hsCRP)?
I’m trying to get my father-in-law to start it, I’ll send him your photos 
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haha hope it will heps him to start
Yes I’m using tirzepatide, very effective.
I used to have an increased HR when I increased the dosage too fast. Now at 5mg a week I don’t think it is still the case.
HRV was tanked, at least a -75% from baseline, but I injected to much at the beginning, and I was barely eating anything. Now I don’t track it anymore so I don’t know (and btw I’m taking vortioxetine 10mg so it doesn’t help my Hrv neither)
No bloodwork to compare but I was already perfect on FBG and cholesterol (thanks to Jardiance ezetimibe and pravastatin I guess)
These drugs are a blessing. No more eating disorder for me, I can eat a meal and think to anything else like a normal person. No more obessed with food.
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adssx
#156
Hum HRV is a bit concerning. Didn’t you mention starting nebivolol to compensate for the increased HR? If you measure your HRV again I’d love to know how much it is now and whether it went back to baseline or not.
Pat25
#157
Jeanbaptiste, did you share your exercise program somewhere or do you mind sharing it? Your results are remarkable indeed: congrats!
I can try to measure it in the next few days, I just have to charge my Whoop, or maybe next week (I’m currently sick)
I was indeed taking nebivolol to lower my HR but I rapidly became hypotensive to the point I could fall and lose consciousness when I stand up to fast so I stopped it.
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I didn’t train at all. I just work in a restaurant where I walk a lot and sometimes the shift can be very cardio.
12000 to 15000 steps on average, and almost all my day standing up.
I’m going to do resistance training back like few years ago to get really more muscular, and improve my posture
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LukeMV
#160
Good job on the results but your cropping skills in the first picture needs some work
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I will do that sorry 
Thank you by the way!
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One of the greatest benefits of these peptides.
I still enjoy a good meal and I occasionally get “hungry” but never obsessed and never out of control.
But I do prefer Retatrutide over Tz. I find it less “intrusive” and a bit more natural, with better weight management.
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Davin8r
#163
Seriously!
. I was reading this thread at work and it’s pure luck that nobody saw my screen. Who knows what they would have thought?
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